Method for extracting and separating Chinese medicinal components by subcritical fluid

A subcritical fluid and extraction technology, applied in the direction of solid solvent extraction, etc., to prevent oxidation and escape, and maintain the effect of active ingredients

Inactive Publication Date: 2013-02-13
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the main research and application fluid of supercritical extraction is carbon dioxide, but there are few research and application for other fluids
Carbon dioxide is a non-polar fluid, and its solubility for many components with strong polarity is obviously insufficient. Carriers are introduced into the extract, which are not easily removed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Step 1. Put crushed hops in a 1-liter supercritical extraction kettle, compact them, and put 350 grams of hops in total. Vacuumize the system to make the pressure in the container negative, pass in nitrogen to drive away the residual air, then evacuate again, inject propane to extract under subcritical conditions. The extraction pressure is 4 MPa, the temperature is room temperature, and the flow rate of propane is 6 liters / hour. The pressure of the primary separator is 1MPa, the temperature is 40°C; the pressure of the secondary separator is 0.5MPa, the temperature is 40°C, and the extraction time is 2 hours. After the extraction is finished, the product in the separation tank is taken out, and the Chinese medicine raw materials in the extraction tank are then extracted in the next step.

[0032]Extraction in this step obtains 33 grams of light green or yellow extract, which contains 41% of alpha acid, 38% of beta acid and 6% of hop essential oil after analysis. Main...

Embodiment 2

[0040] Step 1. Put crushed hops in a 1-liter supercritical extraction kettle, compact them, and put 350 grams of hops in total. Vacuumize the system to make the pressure in the container a negative pressure, inject nitrogen to drive out the residual air, vacuumize again, inject carbon dioxide to extract under subcritical conditions. The extraction pressure is 10 MPa, the temperature is room temperature, and the flow rate of carbon dioxide is 6 liters / hour. The pressure of the primary separator is 5MPa, the temperature is 40°C; the pressure of the secondary separator is 3MPa, the temperature is 40°C, and the extraction time is 2 hours. After the extraction is finished, the product in the separation tank is taken out, and the Chinese medicine raw materials in the extraction tank are then extracted in the next step.

[0041] In this step, 35 grams of light green or yellow extract is extracted, which contains 45% of alpha acid, 40% of beta acid and 5% of hop essential oil after a...

Embodiment 3

[0044] Step 1, with embodiment 1.

[0045] Step 2, keep the raw materials extracted in the previous step in the extraction kettle, vacuumize the container, make the pressure in the container negative, feed nitrogen to drive away the residual air, vacuumize again, inject dichlorodifluoromethane in the sub- Extraction under critical conditions. The extraction pressure is 3 MPa, the temperature is room temperature, and the dichlorodifluoromethane flow rate is 6 liters / hour. The pressure of the primary separator is 0.6MPa, the temperature is 35°C; the pressure of the secondary separator is 0.3MPa, the temperature is 35°C, and the extraction time is 2 hours. After the extraction is finished, the product in the separation tank is taken out, and the raw material in the extraction tank is then extracted in the next step.

[0046] In this step, 6.2 grams of paste were extracted, which contained 20% of α-acid, 21% of β-acid and 9.5% of hop polyphenol after analysis.

[0047] Step 3, ...

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PUM

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Abstract

The invention discloses a method for extracting and separating Chinese medicinal components by subcritical fluid, and belongs to the technical field of fine chemical industry. By adopting solvents with different polarities, the different Chinese medicinal components are extracted and separated step by step in a subcritical state according to a weak-strong sequence of the solvents. The method can be used for systematically extracting and separating various components from Chinese medicaments, and is suitable for industrialized production; and the whole process is carried out nearly at room temperature, so that oxidation and escape of heat-sensitive substances are effectively prevented, and active ingredients of Chinese medicinal plants are furthest kept.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and in particular relates to a method for separating components of traditional Chinese medicines. Background technique [0002] The ingredients contained in Chinese herbal medicine are very complex, including active ingredients, invalid ingredients and toxic ingredients. In order to improve the therapeutic effect of Chinese herbal medicine, it is necessary to extract the active ingredients as much as possible and remove the ineffective and toxic ingredients. Therefore, the extraction of Chinese herbal medicine is the most important for improving the intrinsic quality and clinical efficacy of Chinese medicine preparations. In the Pharmacopoeia of the People's Republic of China (2010 edition), in addition to retaining the 31 kinds of traditional Chinese medicine extracts already included in the 2005 edition, 16 kinds of extracts were added. [0003] The national pharmacopoeia includes ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02
Inventor 刘启民程桂茹
Owner CHANGCHUN UNIV OF TECH
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