Method for preparing compound 'chenxiangwei'medicine and new use thereof
A drug and compound technology, applied in the field of medicine, can solve the problems of low content of active ingredient nobiletin, inability to play a good therapeutic effect, no substantive characteristics and progress, etc., to achieve the reduction of adverse reactions, rapid onset, and dissolution short duration effect
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Embodiment 1
[0033] Tangerine peel 80g woody 20g calamus 11g rhubarb 20g sodium bicarbonate 20g aluminum hydroxide 80g heavy magnesium carbonate 20g
[0034] Take tangerine peel and extract twice with 75% ethanol at reflux for 2 hours each time. Combine the extracts and recover the ethanol to obtain the liquid extract for use; steam distilled woody and calamus for 2 hours each time. The volatile oil is separate Store in a container, filter the distillate, and concentrate it into a liquid extract for later use; take rhubarb, pulverize it into a medium-fine powder of 80, and then superfinely pulverize it into a micron powder of 0.1μm-10μm and a nanopowder less than 0.1μm, 10μm-150μm The mixed powder of the dried tangerine peel, and reserve for use at a powder yield of not less than 95%; sodium bicarbonate, heavy magnesium carbonate, and aluminum hydroxide were pulverized into fine powder, and passed through a 120-mesh sieve for use; Combine Muxiang and Shichangpu fluid extract, add rhubarb powd...
experiment example 1
[0035] Experimental example 1 Analgesia test (twisting method)
[0036] Thirty mice were taken, half male and half male, weighed, and randomly divided into 3 groups. The corresponding drugs were administered at clinical doses. The control group was administered with an equal volume of normal saline. 30 minutes after gavage, each group was intraperitoneally injected with 0.6% With glacial acetic acid solution (0.2ml / head), observe the group's writhing times within 30 minutes and calculate the analgesic rate. The results are shown in Table 1.
[0037] Table 1 Effects of Compound Chenxiangwei Medicine on Chemical Pain in Mice ( n=10)
[0038] Group
Dosage / g.kg
Number of twists
Analgesia rate (%)
Saline group
Compound Chenxiang Stomach Medicine
Xianglian Wan Group
0.2ml / only
97.40
17.55
18.5±2.0
5.0±1.4 **
13.2±5.8 *
72.43
28.65
[0039] Compared with the normal saline group, * P** P<0.01
[0040] The results show that the analgesic rate of th...
Embodiment 2
[0048] Tangerine peel 75g woody 25g calamus 15g rhubarb 25g sodium bicarbonate 20g aluminum hydroxide 75g heavy magnesium carbonate 20g
[0049] Take the dried tangerine peel and add 10 times the weight of 80% ethanol for reflux extraction for two times. The ethanol is recovered for 2 hours each time to obtain the liquid extract, which is used for later use. The woody and Shichangpu are respectively distilled twice with 8 times the weight of water. One time 2 hours, the second time 1.5 hours, the volatile oil is stored separately, the distillate is filtered, and concentrated into a liquid extract for later use; take rhubarb and superfinely pulverize it into a mixed powder of 0.1μm-10μm micron powder and less than 0.1μm nanopowder Sodium bicarbonate, heavy magnesium carbonate, and aluminum hydroxide are crushed into fine powders and passed through a 120-mesh sieve for use; the dried tangerine peel extract and woody, Acorus calamus fluid extract is combined, rhubarb powder, sodium ...
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