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Method for synthesizing 4-reanal condensation chrysanthemic acid hapten

A technology of aminobutyric acid and synthesis method, applied in chemical instruments and methods, preparation of organic compounds, preparation of carboxylic acid amides, etc., can solve the problems of expensive instruments, difficult to achieve on-site detection, cumbersome and other problems, and achieve simple synthesis steps. Effect

Active Publication Date: 2008-07-16
山东美正生物科技有限公司
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Problems solved by technology

However, traditional pesticide residue analysis mainly relies on gas chromatography, liquid chromatography, gas chromatography-mass spectrometry, liquid chromatography-mass spec

Method used

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  • Method for synthesizing 4-reanal condensation chrysanthemic acid hapten
  • Method for synthesizing 4-reanal condensation chrysanthemic acid hapten

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Embodiment 1

[0014] (1) Dissolve 1.68g (0.01mol) chrysanthemic acid in 3mL DMF (N,N-dimethylformamide) in a small reaction flask equipped with a stirrer, then add a small amount of n-butylamine, and stir for 30min Add 1.3658g of isobutyl chloroformate (0.01mol), lower the temperature to 0°C, and react for 1h, which is called reaction solution A; in addition, weigh 1.03g of 4-aminobutyric acid (0.01mol) and dissolve it in 5mL of carbonic acid with a pH of 9.6 In the salt buffer solution, it is called solution B; then slowly drop the reaction solution A into the carbonate buffer solution B dissolved in 4-aminobutyric acid at 0°C, and react for 1.5 hours, called the reaction solution C .

[0015] (2) Thin-layer chromatography detection end point: draw a horizontal line at 1 cm from the lower end of the silica gel sheet, draw 1 μL of the reaction solution C and point it on the line, dry it after sample application, put the thin plate into the chromatography cylinder, and the chromatography liq...

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Abstract

The invention discloses a method for synthesizing 4-aminobutyric acid condensation alantic acid hapten, belonging to the field of biochemical engineering technology. The invention takes an alantic acid and a 4-aminobutyric acid as raw materials to synthesize a derivative of the alantic acid, 4-aminobutyric acid condensation alantic acid hapten through the reaction with two steps. The invention successfully synthesizes the derivative of the alantic acid, 4-aminobutyric acid condensation alantic acid hapten, and the synthesizing procedures are simple with a purity of over 98 percent after post-treatment, which can be completely used as a standard sample, thus providing a convenient means for human to study the enzyme linked immuno sorbent assay of the pyrethroid with alantic acid and satisfying the needs for the research at home and abroad.

Description

technical field [0001] The invention discloses a method for synthesizing 4-aminobutyric acid condensed chrysanthemic acid hapten, which belongs to the technical field of biochemical industry. Background technique [0002] Chrysanthemum acid, English name: Chrysanthemic Acid, molecular formula is C 10 h 16 o 2 , is an intermediate in the synthesis of chrysanthemic acid-containing pyrethroid pesticides. Pyrethroids are a class of biomimetic drugs developed on the basis of the chemical structure of natural pyrethroids. The application of natural pyrethrum has a long history. Because of its strong knockdown power, fast insecticidal effect, broad spectrum, easy degradation, low toxicity to higher animals and birds, safe use, and little environmental pollution, it is widely used Widely used in tea gardens, orchards, farmland and other pest control. With the improvement of international standards, the internationalization of my country's trade, and the strict green barriers, t...

Claims

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Application Information

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IPC IPC(8): C07C233/63C07C231/02G01N30/90
Inventor 胥传来郝晓蕾殷祥刚冀宝庆
Owner 山东美正生物科技有限公司
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