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Micro-pore starch particles and producing method thereof

A technology for microporous starch and starch granules, which is applied in the field of microporous starch granules and its production, can solve the problems of insufficient drug loading, insufficient loading, difficulty in preparing preparations, etc., and achieves ideal application prospects, low price, and edible safe effect

Active Publication Date: 2008-08-13
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pore size of microporous starch is between 1 and 2 microns. As a carrier, its application is limited. The main disadvantage is that the loading capacity is not large enough. If it is used as a drug carrier, it is difficult to make an ideal preparation if the drug loading capacity is not enough.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Weigh 500g of cornstarch (produced by Shandong Zaozhuang Xiangyu Cornstarch Co., Ltd.), add 100g of water, seal and let stand for 48 hours to make the moisture even in the starch, then heat it at 90°C for 30 minutes, add 900g of water, and stir evenly. Add 225,000 units of amylase (produced by Jiangsu Wuxi Xuemei Enzyme Technology Co., Ltd.), control the pH to 5.5, and incubate and stir the reaction at 55°C for 6 hours. After the enzymatic hydrolysis reaction is completed, spray-dry to obtain microporous starch granules. Take a small amount of microporous starch granules and place them on the stage of the scanning electron microscope, put the stage into the gold plating instrument, spray carbon and gold-plate the sample, take out the stage after 2 hours and put it into the scanning electron microscope, observe the microporous starch The pore size of the micropores on the particle surface is compared with the scale, and the measured surface pore size ranges from 5 to 8 μm...

Embodiment 2

[0014] Weigh 1000g of potato starch (produced by Hebei Weichang Jiefeng Potato Starch Company), add 400g of water, seal and let stand for 24 hours to make the moisture even in the starch, then heat at 55°C for 120 minutes, add 3600g of water, stir evenly, add 650,000 units of amylase (manufactured by Jiangsu Wuxi Xuemei Enzyme Preparation Technology Co., Ltd.), controlled at pH 4.5, was incubated and stirred at 35°C for 2 hours. After the enzymatic hydrolysis reaction was completed, it was spray-dried to obtain microporous starch granules. Take a small amount of microporous starch granules and place them on the stage of the scanning electron microscope, put the stage into the gold plating instrument, spray carbon and gold-plate the sample, take out the stage after 2 hours and put it into the scanning electron microscope, observe the microporous starch The pore size of the micropores on the particle surface is compared with the scale, and the measured surface pore size ranges fr...

Embodiment 3

[0016] Weigh 800g of sweet potato starch (produced by Dongguan Huimei Starch Technology Co., Ltd.), add 240g of water, seal and let stand for 36 hours to make the moisture even in the starch, then heat it at 70°C for 60 minutes, add 2160g of water, and stir evenly. Add 480,000 units of amylase (produced by Jiangsu Wuxi Xuemei Enzyme Preparation Technology Co., Ltd.), control the pH to 5.0, and incubate and stir the reaction at 45°C for 3 hours. After the enzymatic hydrolysis reaction is completed, spray-dry to obtain microporous starch granules. Take a small amount of microporous starch granules and place them on the stage of the scanning electron microscope, put the stage into the gold plating instrument, spray carbon and gold-plate the sample, take out the stage after 2 hours and put it into the scanning electron microscope, observe the microporous starch The pore size of the micropores on the particle surface is compared with the scale, and the measured surface pore size ran...

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Abstract

The invention provides a microporous starch grain with aperture over 5 mu m, and relatively high supporting capacity, and producing method thereof. The producing method includes: weight starch, charging water with a weight of 20-40% of the starch weight, sealed standing for 24-48 hours to make the water disperse uniformly in the starch, heating to keep temperature ranging from 55 to 90 DEG C. for 30-120 minutes, charging water to make weight ratio of starch and water to 1:2 - 4, stirring uniformly, charging amylase according to a charging amount of 450-650 per grams of starch, stirring and reacting for 2-6 hours with pH ranging from 4.5 to 5.5, temperature ranging 35-55 DEG C., spray drying after completion of the reaction, aforementioned microporous starch grain is obtained. The inventive microporous starch grain has a surface aperture of 5-10 mu m, 3-10 times large than microporous starch grain prepared by conventional technology, thus has a better supporting property, and larger supporting capacity than products of conventional technology, which makes it has better effects than products of conventional technology when applied to fields of medicament preparation, food additive, pesticide and fertilizer as carrier.

Description

(1) Technical field [0001] The invention relates to a microporous starch granule and a production method thereof. (2) Background technology [0002] The starch is processed into starch granules with microporous surfaces. A large number of technical researches have been carried out at home and abroad. The microporous starch granules produced by the existing technology have a pore size of 1 to 2 microns on the surface of the starch granules. The starch granules produced by the two techniques are produced by enzymatic hydrolysis after ultrasonic treatment, or directly by enzymatic hydrolysis. The distribution of micropores on the surface of the starch granules produced by the two techniques is different, and the starch granules produced by direct enzymatic hydrolysis have fewer surface pores. The pore size of microporous starch is between 1 and 2 microns. As a carrier, its application is limited. The main disadvantage is that the loading capacity is not large enough. If it is u...

Claims

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Application Information

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IPC IPC(8): C08J9/00C08L3/02C12S3/12
Inventor 钱俊青应雪肖
Owner ZHEJIANG UNIV OF TECH
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