Medicine carrying fibroin microsphere and preparation thereof
A technology of drug-loaded microspheres and silk fibroin, applied in the fields of biomedicine and polymer chemistry, can solve the problems of reproduction and the integrity of biological macromolecules, such as side effects, and achieve stable performance
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Embodiment 1
[0023] Add 120g of silkworm seed cocoon cocoon shells to 50 times the amount of 0.1% sodium carbonate aqueous solution and boil for 30 minutes, take it out and wash it with water, repeat the above operation 1 to 2 times to ensure that all the sericin is removed, and finally degummed After the silk fibroin fiber was washed with deionized water, it was dried at 60°C for later use.
[0024] Take 10 g of the above-mentioned degummed silk fiber and dissolve it in 100 ml of calcium chloride / ethanol / water ternary solution (molar ratio is 1:2:8), and dissolve at 70° C. with constant temperature magnetic stirring. The silk fibroin solution obtained above is dialyzed, desalted and purified to obtain a water-soluble silk fibroin solution with a concentration of 2.5-3.5%, which is concentrated into a 6% water-soluble silk fibroin solution.
[0025] Take the water-soluble drug dexamethasone sodium phosphate, which accounts for 9.1% / wt of the total amount of silk fibroin, add the above-ment...
Embodiment 2
[0028] Add 120g of waste silk to 50 times the amount of 0.1% sodium carbonate aqueous solution and boil for 30 minutes, take it out and wash it with water, repeat the above operation 1 or 2 times to ensure that all the sericin is removed, and finally the degummed silk fiber After washing with deionized water, dry at 60°C for later use.
[0029]Take 20 g of the above-mentioned degummed silk fibers and dissolve them in 200 ml of calcium chloride / ethanol / water ternary solution (molar ratio is 1:2:8), and dissolve at 72° C. with constant temperature magnetic stirring. The silk fibroin solution obtained above is dialyzed, desalted and purified to obtain a water-soluble silk fibroin solution with a concentration of 2.5-3.5%.
[0030] Take 16.7% / wt of water-soluble drug vitamin C, which accounts for the total amount of silk fibroin, and add it to the above-mentioned water-soluble silk fibroin solution with a concentration of 2.5-3.5% / wt and stir evenly, then add 3% (v / v) In the liqu...
Embodiment 3
[0033] Add 60 g of waste silk to 50 times the amount of 0.1% sodium carbonate aqueous solution and boil for 30 minutes, take it out and wash it with water, repeat the above operation 1 to 2 times to ensure that all sericin is removed. Finally, the degummed silk fibers are washed with deionized water, and then dried at 60° C. for later use.
[0034] Take 10 g of degummed silk fiber and dissolve it in 100 ml of 9.0 mol / L BrLi solution, and dissolve it under constant temperature magnetic stirring at 70°C. The silk fibroin solution obtained above is dialyzed, desalted and purified to obtain a water-soluble silk fibroin solution with a concentration of 2.5-3.5%.
[0035] Take water-soluble hormone drugs accounting for 9.0% / wt of the total amount of silk fibroin, add the above-mentioned concentration of 2.5-3.5% / wt water-soluble silk fibroin solution and stir evenly, then add olive oil containing 0.8% (v / v) lecithin In 37°C, stir at 650rpm for 30 minutes at a stirring speed of 650r...
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