Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Medicinal composition containing cefdinir cyclodextrin inclusion compound and preparation thereof

A technology of cyclodextrin inclusion complex and cefdinir, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, nano-drugs, etc., to achieve easy dissolution, high water solubility, and little hemolytic side effect. Effect

Inactive Publication Date: 2008-09-17
NANJING NORMAL UNIVERSITY +1
View PDF1 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of cyclodextrin in the preparation of cefdinir preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition containing cefdinir cyclodextrin inclusion compound and preparation thereof
  • Medicinal composition containing cefdinir cyclodextrin inclusion compound and preparation thereof
  • Medicinal composition containing cefdinir cyclodextrin inclusion compound and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Mix 28g of β-cyclodextrin with 30ml of pure water, heat, add 10g of cefdinir at 50°C, mix well, add dilute NaHCO drop by drop 3 (0.1M) solution, stirred for 3 hours, neutralized by adding an equal volume of dilute hydrochloric acid (0.1M) dropwise, then cooled at 5°C for 24 hours; removed water under reduced pressure at a temperature not higher than 50°C, and dried to obtain a solid clathrate.

Embodiment 2

[0076] Basically the same as Example 1, but with 100 g of β-cyclodextrin mixed with 100 ml of pure water.

Embodiment 3

[0078] Basically the same as Example 1, but with 1000 g of β-cyclodextrin mixed with 1000 ml of pure water.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicine composition comprising the cefdinir cyclodextrin inclusion compound. The basic composition comprises the cefdinir and the pharmacy-acceptable cyclodextrin; the cyclodextrin is chosen from one or a plurality of Beta-cyclodextrin, sulfobutyl- Beta -cyclodextrin, hydroxypropyl- Beta-cyclodextrin or hydroxypropyl-sulfobutyl- Beta -cyclodextrin. The invention has an advantage of increasing the solubility, stability and activity of the cefdinir. The invention also provides the preparation method of the medicine composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing cephalosporin antibiotic cyclodextrin inclusion complex and a preparation method thereof. Background technique [0002] Cefdinir (cefdinir; cefuroxime axetil), trade name: cefdinir or Cefzon, chemical name: [6R-[6α, 7β(z)]]-7-[[(2-amino-4- Thiazolyl)-(oximino)acetyl]amino]-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, molecular formula :C 14 h 13 N 5 o 5 S 2 , molecular weight: 395.42. The routine dosage of this product for adults is about 100mg each time, three times a day; the routine dosage for children is 9-18mg / kg per day, taken in three divided doses. Cefdinir is the third generation of new oral cephalosporin antibacterial drugs. The characteristic structure of the aminothioxime side chain not only enhances the antibacterial activity against Gram-negative bacteria and the stability against β-lactamase, but also has strong Gram-positive cocci activity, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/546A61K47/40A61P31/04
CPCC08B37/0015A61K31/724A61K31/545A61K47/48969B82Y5/00A61K31/546A61K47/6951A61P31/04
Inventor 任勇高剑锋韩彬彬马学琴
Owner NANJING NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com