Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cysticercosis cellulosae recombination gene, vaccin and preparation thereof

A recombinant gene and swine cysticercosis technology, which is applied to the field of oral vaccines and the preparation of such vaccines, can solve problems such as the harm of side effects of drug treatment, and achieve the effects of protecting the host, increasing the range of immunity and improving the stability.

Inactive Publication Date: 2008-10-01
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no mature method for the prevention and treatment of cysticercosis. Several chemical drugs have played an important role in the treatment of cysticercosis. For example, benthimazole and praziquantel have good effects on expelling and treating cysticercosis, but With the long-term and repeated use of people, the side effects caused by drug treatment and the possible harm to the human body caused by drug residues in food have shown the limitations of drug treatment alone

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cysticercosis cellulosae recombination gene, vaccin and preparation thereof
  • Cysticercosis cellulosae recombination gene, vaccin and preparation thereof
  • Cysticercosis cellulosae recombination gene, vaccin and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] Examples of the invention are provided below:

[0036] 1. bacterial classification and plasmid used in the present invention

[0037] Escherichia coli X6212 (Δasd) (hereinafter referred to as X6212), Salmonella intermediate host X3730 (Δasd, Tc s ,Str r , ΔGal) (hereinafter referred to as X3730), Salmonella terminal host X4550 (Δasd, Δcrp, Nal r , Δcya) (hereinafter referred to as X4550) and Salmonella expression vector pYA3342 (asd + expression vector, asd - / asd + ). The above strains are disclosed in US Patent No. 6,872,547.

[0038] 2. Preparation of TsoL18 target gene

[0039] 1) Hatching and activation of Taenia solium eggs

[0040] Smash fried pumpkin seeds and feed them to patients with taeniasis, and take concentrated betel nut juice 30 minutes later to deworm them, so as to ensure the integrity of the insects and the vitality of the eggs. According to the length of the proglottids, select the terminal mature proglottids of Taenia solium, wash them wit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a taenia solium oncosphere recombination gene and the preparing method of the recombination gene, and the use of the recombination gene, especially an oral vaccine for preventing pig cysticercosis prepared by the recombination gene and a preparing method of the vaccine. The recombination gene of the invention removes the signal peptide bases in the original sequence of TsoL18 gene of taenia solium oncosphere, and mutates the partial bases. The vaccine of the invention is recombining attenuation Salmonella enterica which carries with the taenia solium oncosphere TsoL18 recombination gene, and the gene can be expressed in the immunologic effector cells parasitized in attenuated salmonella typhimurium and / or salmonella.

Description

technical field [0001] The present invention relates to the recombinant gene of Taenia solium, the preparation method of the recombinant gene, the use of the recombinant gene, especially the oral vaccine for preventing and treating porcine cysticercosis prepared by using the recombinant gene and the preparation of the recombinant gene Methods of vaccine preparation. Background technique [0002] Taeniasis solium (Taeniasis solium) is a zoonotic disease with worldwide distribution. The eggs of Taeniasis solium (oncosphere) are swallowed by intermediate hosts such as pigs or wild boars and develop into larval cysts of Taeniasis solium. Cysticercus cellμlose, people are very susceptible to Taenia solium infection after eating pork infected with cysticercus or touching items contaminated with cysticercus. Therefore, porcine cysticercosis not only causes economic loss to animal husbandry, seriously affects the quality of meat products, but more importantly, seriously endangers h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/30C12N15/10C12N15/63A61K48/00A61P33/02
Inventor 才学鹏丁军涛王颖陈晓宇骆学农郑亚东景志忠
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com