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Medicament for preventing and treating Alzheimer's disease

A technology of drugs and pharmaceutical preparations, applied in the field of medicine

Inactive Publication Date: 2008-11-05
赵全成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before the completion of the present invention, there was no report on the use of total flavonoids of Selaginella chinensis and biflavonoids of Spicy fir for the prevention and treatment of senile dementia

Method used

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  • Medicament for preventing and treating Alzheimer's disease
  • Medicament for preventing and treating Alzheimer's disease
  • Medicament for preventing and treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Extraction and preparation of total flavonoids of Selaginella:

[0046] Medicinal material 1kg, with 8 times of 30-95% ethanol (preferably 75% ethanol) reflux extraction 2-3 times, extract 1~3 hour each time, decolorize with the activated carbon of extracting solution 1.5% (w / v), reclaim ethanol to No alcohol smell, add deionized water to adjust the concentration to 1.5g / ml of medicinal materials, adjust the pH to 4~5, let it stand for 24 hours, filter or centrifuge, take the precipitate, dissolve it with ethanol, and mix the ethanol soluble part into the pre-treated In D101 or AB-8 macroporous resin, fully adsorb, shake off the ethanol, add the macroporous resin of the adsorbed sample to the upper end of the pre-installed macroporous resin column, first elute 3-4BV with 30-40% ethanol , and then eluted 3-4BV with 60-70% ethanol, collected the eluted part of 60-70% ethanol, recovered the ethanol, and dried to obtain the total flavonoids of Selaginella.

Embodiment 2

[0047] Example 2 Preparation of Biflavone

[0048] Separation and purification of the total flavonoids of Selaginella chinensis on a C-18 reverse-phase column (atmospheric pressure), using 20-50% aqueous methanol as the eluent, collecting the biflavonoid fractions of Selaginella chinensis, combining them after TLC identification, and evaporating part of the solvent , to obtain the crystallization of the biflavone of Suicha chinensis.

Embodiment 3

[0049] Example 3 (capsules)

[0050] 100g of abiflavonoids or total flavonoids raw materials, appropriate amount of medicinal starch, mixed evenly, granulated, dried, granulated, filled into No. 1 capsules, made into 1000 capsules, and ready. Take 1 capsule of biflavones each time and 2 capsules of total flavonoids each time, 3 times a day.

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Abstract

S. pvlvinata (Hook.et Gev.) Maxim of Selaginella of Selaginellaceae, S. tamariscina (beav.) spring, S. moellendorfii Hieron and so on are taken as raw materials for extraction and separation of total flavonoids of the Selaginella and the single component amentoflavone thereof, thus preparing a pharmaceutical preparation for prevention and treatment for Alzheimer disease.

Description

technical field [0001] The present invention relates to the new medical application of the total flavonoids of Selaginella chinensis and the biflavones of Selaginella chinensis, specifically the application of the total flavonoids of Selaginella chinensis and the biflavonoids of Selaginella spiconiae in the prevention and treatment of senile dementia, and also relates to the drug The extraction, separation and pharmaceutical preparation of the invention belong to the technical field of medicine. Background technique [0002] Alzheimer's is a degenerative disease of the central nervous system. It is mainly manifested in the middle-aged and old age with progressive memory impairment and intellectual loss, memory impairment, abstract thinking disorder, language disorder, behavior and direction disorder and other symptoms. Its pathogenesis is not very clear, it is a very complicated process of nerve and cell aging. Therefore, the prevention and treatment of senile dementia is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61K9/20A61K9/48A61K9/16A61K9/10A61K47/38A61K47/36A61K47/32A61P25/28A61P25/00A61K31/352
Inventor 赵全成张莲珠南敏伦吕雪峰王莲萍
Owner 赵全成
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