Compound breviscpini soft capsule and its preparation method

A technology of scutellaria breviscapus and soft capsules, which can be used in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve problems such as insufficient purity, and achieve the effects of improving microcirculation, sleep, and hypoxia resistance

Inactive Publication Date: 2008-11-19
红河千山生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its application number is 92108623.7 "Erigeron breviscapita capsules and its production method", the main component extract is crude product, the purity is not enough

Method used

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  • Compound breviscpini soft capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Get 200 kilograms of breviscapus with a particle size of 2-10 cm, extract 3 times with 75% ethanol solution at 80° C., extract 1 hour each time, and the amount of solvent for the 3 times is respectively 2000, 1600, and 1600 liters; combine the extracts, reclaim Solvent, concentrate the volume of the feed liquid to 200 liters; add 200 liters of water of equal volume to the feed liquid, heat to 70°C, adjust the pH of the feed liquid to 7.0 with sodium hydroxide solution, let stand for 24 hours, take the filtrate and heat to 70°C , adjust the pH=2.0 with sulfuric acid, filter after standing for 12 hours, discard the filtrate, filter the cake, which is No. Filtrate, recover the solvent from the filtrate, and filter the cake, which is the No. 2 intermediate product; then dissolve it with 30% ethanol solution 10 times, heat to 70°C, adjust the pH to 7.0 with sodium hydroxide solution, let it stand for 8 hours, and then heat to 70°C , adjust the pH to 2.0 with sulfu...

Embodiment 2

[0023] Example 2: Repeat Example 1 with the following differences, extract twice with 50% ethanol at 90°C, extract for 3 hours each time, concentrate and combine the filtrate, heat to 60°C to adjust pH=7.5, and after standing for 12 hours, heat to Adjust the pH to 2.5 at 60°C, let stand for 5 hours and filter to obtain intermediate product No. 1, then dissolve and wash with 45% ethanol and 75% ethanol respectively until light yellow, filter to obtain intermediate product No. 2; then dissolve with 20% ethanol for 5 times, Heat to 60°C, adjust PH=6.5, let stand for 1 hour; heat again to 60°C, adjust PH=1.5, let stand for 1 hour, filter to get No. 3 intermediate product; then dissolve and wash with 45% ethanol and 75% ethanol respectively, Filter and dry to obtain the finished product of breviscapine.

[0024] Fully mix according to scutellarin: notoginseng glycosides: rutin 11:6:10, crush until the particle size is 80-120 mesh, accounting for more than 98%, use soybean oil to ev...

Embodiment 3

[0025] Example 3: Repeat Example 1 with the following differences, extract 5 times with 80% ethanol at 70°C, extract 0.5 hours each time, concentrate and combine the filtrate, heat to 80°C to adjust PH=6.5, and after standing for 36 hours, heat to Adjust pH to 1.5 at 80°C, let stand for 24 hours and filter to obtain intermediate product No. 1, then dissolve and wash with 60% ethanol and 95% ethanol respectively until light yellow, filter to obtain intermediate product No. 2; then dissolve with 50% ethanol 15 times, Heat to 80°C, adjust PH=7.5, let stand for 12 hours; heat again to 80°C, adjust PH=2.5, let stand for 24 hours, filter to obtain No. 3 intermediate product; then dissolve and wash with 60% ethanol and 95% ethanol respectively, Filter and dry to obtain the finished product of breviscapine.

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Abstract

The invention relates to a compound soft erigeron breviscapus capsule and the preparation method thereof. The method comprises the steps of using ethanol as solvent; extracting breviscapinun from the material of breviscapus through the hot reflux method; taking the breviscapinun as a main ingredient; adding Panax notoginseng notoginseoside and ludin as raw materials; and preparing the compound soft capsule by using 11-34g of breviscapinun per thousand capsules, 6-20g of Panax notoginseng notoginseoside per thousand capsules, and 10-31g of ludin per thousand capsules, and 100-300g of edible vegetable oil per thousand capsules. The compound soft capsule has the cardio-cerebrovascular disease preventing function, and adjuvant therapy function for patients. The health care product has no adverse effect after long-term administration, and produces no resistance to drugs.

Description

1. Technical field [0001] The invention relates to a compound breviscapine soft capsule and a preparation method thereof. The compound soft capsule is made of breviscapine extract scutellarin, panax notoginseng and rutin as raw materials, and belongs to the field of health care medicines. 2. Background technology [0002] In recent years, with the improvement of people's living standards, cardiovascular and cerebrovascular diseases have become a common and frequently-occurring disease, and this type of disease is difficult to cure. At present, there are a large number of therapeutic drugs for this type of disease on the market, but after long-term use, they all produce a certain degree of Toxic side effects and drug resistance, so people are still researching or looking for medicines or health products that can completely cure or effectively control such diseases; [0003] Erigeron breviscapus (Vant.) Hand.-Mazz., also known as Erigeron breviscapus, belongs to the genus Erig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/48A61P9/00A61K31/7048
Inventor 杨建文张意童黄胜林吴道聪倪建芳王升云
Owner 红河千山生物工程有限公司
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