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Application of standard extract of pseudo-ginseng in preparing medicament for preventing and controlling senile dementia

A technology of senile dementia and extract, applied in the field of medicine

Active Publication Date: 2008-12-10
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Senile dementia still has no good prevention and treatment measures

Method used

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  • Application of standard extract of pseudo-ginseng in preparing medicament for preventing and controlling senile dementia
  • Application of standard extract of pseudo-ginseng in preparing medicament for preventing and controlling senile dementia
  • Application of standard extract of pseudo-ginseng in preparing medicament for preventing and controlling senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1: Jianshenning tablet:

[0080] Prescription (1000 tablets):

[0081] Panax notoginseng standard extract 100g

[0082] Medicinal starch 160g

[0083] Magnesium Stearate 2g

[0084] Among them, Panax notoginseng standard extract contains ginsenoside Rb 1 (C 54 h 92 o 23 ) weight percent is 12.04%, ginsenoside Rg 1 (C 42 h 72 o 14 ) is 11.91%, notoginsenoside R 1 (C 47 h 80 o 18 ) is 3.02%, Panax notoginseng is 0.05%.

[0085] Preparation method: Pass the materials through a 100-mesh sieve, weigh the materials according to the prescription amount, mix evenly, stir to make a soft material, granulate with a 18-24 mesh sieve, ventilate and dry at 70°C, compress into tablets, and coat with sugar.

Embodiment 2

[0086] Embodiment 2: Panax notoginseng standard extract film-coated tablet;

[0087] Prescription (1000 tablets):

[0088] Panax notoginseng standard extract 100g

[0089] Medicinal starch 160g

[0090] Magnesium Stearate 2g

[0091] Among them, Panax notoginseng standard extract contains ginsenoside Rb of diol group 1 (C 54 h 92 o 23 ) weight percentage is 11%, the ginsenoside Rg of triol group 1 (C 42 h 72 o 14 ) is 11%, notoginsenoside R 1 (C 47 h 80 o 18 ) is 3%, notoginseng flavonoids is 0.05%, and small molecule notoginseng polysaccharide is 12%.

[0092] Preparation method: Pass the materials through a 100-mesh sieve, weigh the materials according to the prescription amount, mix them evenly, stir to make a soft material, granulate with a 18-24 mesh sieve, ventilate and dry at 70°C, press into tablets, and coat with a film.

Embodiment 3

[0093] Embodiment 3: Panax notoginseng standard extract dispersible tablet;

[0094] Prescription (1000 tablets):

[0095] Panax notoginseng standard extract 100g

[0096] Microcrystalline Cellulose 70g

[0097] Lactose 80g

[0098] Internally added cross-linked polyvinylpyrrolidone 25g

[0099] Extra cross-linked polyvinylpyrrolidone 25g

[0100] Micronized silica gel 4g

[0101] Aspartame 4g

[0102] Magnesium Stearate 2g

[0103] Low-substituted hydroxypropyl cellulose 12.5g

[0104] Among them, Panax notoginseng standard extract contains ginsenoside Rb of diol group 1 (C 54 h 92 o 23 ) weight percentage is 11%, the ginsenoside Rg of triol group 1 (C 42 h 72 o 14 ) is 13%, notoginsenoside R 1 (C 47 h 80 o 18 ) is 3%, notoginseng flavonoids is 0.1%, and small molecule notoginseng polysaccharide is 18%.

[0105] Preparation method: pass the materials through a 100-mesh sieve, weigh the materials according to the prescription amount, and mix them evenly. U...

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Abstract

The present invention relates to application of notoginseng standard extraction to preparation of senile dementia prevention medicine. In weight percentage content, the notoginseng standard extraction of the present invention mainly contains 10 to 20 percent of panaxadiol saponins Rb1>(C54H92O23), 10 to 20 percent of panaxatriol saponins Rg1(C42H72O14), 2 to 3.5 percent of notoginseng saponin R1 (C47H80O18), 0.03 to 0.2 percent of notoginseng flavone and 10 to 20 percent of micromolecule notoginseng polyose. Improvement function of notoginseng standard extraction on cognition obstruction of AD model space is observed with Morris water maze experiment and the function mechanism is discussed. In addition, further demonstration is performed on mouse dysmnesia caused by NaNO2. Results prove that the notoginseng standard extraction has obvious improvement effect on learning memory descent caused by senile dementia and cerebral ischemia, and obvious improvement effect on mouse dysmnesia caused by NaNO2 Therefore, the extraction can be used for preventing or curing senile dementia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the new application of the standard extract of Panax notoginseng in the preparation of medicaments for preventing and treating senile dementia. Background technique [0002] Alzheimer's disease is a mental impairment syndrome that occurs in the early and old age and is characterized by brain dysfunction characterized by progressive dementia. Including senile dementia, also known as Alzheimer's disease (Alzheimer disease, AD for short) and cerebrovascular dementia (Vascular dementia, VD for short). Among them, AD is a primary central nervous system degenerative disease that occurs in middle-aged and elderly people; VD is dementia caused by brain damage caused by cerebrovascular disease. The etiology of VD involves two aspects, namely, cerebrovascular disease and risk factors. Risk factors include risk factors for cerebrovascular disease (hypertension, hyperlipidemia, heart dise...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P25/28A61K125/00
Inventor 张伟杨兆祥刘国光刘一丹
Owner KPC PHARM INC
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