Composition for gastroscopy and preparation thereof

Abstract

The invention relates to a combination drug used in the gastroscopy, in particular to a combination drug comprising dimethicone emulsion or simethicone emulsion and analgesics or local anesthetics and a preparaiton method thereof. The combination drug of the invention is mainly prepared by the following raw materials of 0.1wt percent to 5wt percent of analgesics or local anesthetics, 1wt percent to 40wt percent of dimethicone emulsion/simethicone emulsion, 0.1wt percent to 8wt percent of emulsifier, 0wt percent to 20wt percent of thickening agent, 0.01wt percent to 0.5wt percent of antibacterial agent and 27wt percent to 98wt percent of pure water. Compared with the prior art, in the preparation of the invention, the dimethicone emulsion/the simethicone emulsion is scattered and emulsified into liquid drops which have the particle size of about 300nm, large specific surface area, short defoaming time and good effects; liquid drops with the nano size scattered and emulsified by the dimethicone emulsion/the simethicone emulsion have good stability without oil leak, dispersion, etc., when in storage for a long term.

Description

[technical field] [0001] The patent of the present invention relates to a combination drug for gastroscopy, specifically a composition containing simethicone emulsion or simethicone emulsion and analgesic or local anesthetic and its preparation method. [Background technique] [0002] Gastroscopy plays a very important role in the diagnosis of upper gastrointestinal diseases. It is favored by doctors because of its intuitiveness and simplicity, and this examination cannot be replaced by other examinations. However, gastroscopy often causes great pain to patients and brings certain difficulties to clinical diagnosis and treatment. In addition, insufficient observation of gastric body and fundus often results in missed diagnosis. The statistical data from Fukui Prefecture Hospital in Japan from 1979 to 1996 showed that 16.4% of the reasons for the missed diagnosis of gastric cancer by gastroscopy were insufficient observation of lesion sites, especially the cardia, upper gastri...

AI Technical Summary

Problems solved by technology

However, in clinical practice, it is found that the above-mentioned preparations have the following defects: (1) Simethicone in the preparation is in a simple dispersed state, and in order not to affect the appearance of the product, its dosage is lo