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A technology of composition and synbiotic, which is applied in the directions of drug combination, active ingredients of heterocyclic compounds, and pharmaceutical formulations, etc., can solve the problem of affecting the curative effect or health care effect of probiotic products, restricting product storage, transportation and market sales, and being susceptible to the effect of gastric acid. and other problems to achieve the effect of reducing residence time, enhancing immunity and improving resistance
Inactive Publication Date: 2009-02-18
辽宁大生商贸有限公司
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Problems solved by technology
[0012] At present, most microecological preparations have the following problems: probiotic products are mainly live bacterial preparations, most of which are obligate anaerobic bacteria, and are easily affected by external environmental factors such as temperature, oxygen, moisture, and acid-base. more difficult
Probiotic products currently on the market are generally stored at a low temperature of 2~8°C in order to ensure the number of viable bacteria within the validity period, but the low temperature storage conditions limit the storage, transportation and market sales of the products
In addition, the biggest problem with probiotic products is that when probiotic products are taken orally, they are easily affected by gastric acid, and the number of viable bacteria will drop significantly before reaching the intestinal tract, which affects the efficacy or health care of probiotic products effect
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Embodiment 1
[0058] Embodiment 1: Composition and content of synbiotics pharmaceutical composition (single bacteria fermentation / 100g)
[0072] Lactobacillus acidophilus (2.0×10 10 cfu / g) Total 20g
[0073] fructooligosaccharides 25g
[0074] Galactooligosaccharide 25g
[0075] Maltodextrin 10g
[0076] Sucrose 10g
[0077] V B1 , V B2 , V C , V B6 , V B12 1.0g each
Embodiment 3
[0078] Embodiment 3: the preparation of synbiotics pharmaceutical composition
[0079] 1. Cultivation of Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium adolescentis and Lactobacillus acidophilus:
[0080] (1) Strain activation: place the strains stored at low temperature at room temperature for 12 hours, absorb the liquid activation medium and add it to the ampoule tube under aseptic conditions, and inoculate the liquid activation medium and agar plate, 37 Cultivate anaerobically for 72 hours under the condition of ℃, and then continuously activate three generations to serve as the mother culture.
[0081] (2) Preparation of seed culture: Inoculate the mother culture into seed liquid culture medium with an inoculum size of 2%, and anaerobically culture at 37° C. for 18 hours to obtain a seed culture.
[0082] (3) Fermentation culture: insert the seed culture into the fermentation liquid medium, the inoculum size is 5%, anaerobic culture is carried out under ...
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Abstract
The invention relates to a micro-ecological regulator, which belongs to the category of micro-ecological preparations. The product contains Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium adolesentis, lactobacillus acidophilus, fructo-oligosaccharides, galacto-oligosaccharides, vitamins and the like. A concrete production process comprises the following steps: 1. bacterial strains are respectively or jointly subjected to liquid deep high-density cultu, so as to obtain fermentation liquid; 2. after the fermentation liquid is centrifuged, bacterial sludge is collected, added to protective agents and made into freeze-dried powder; 3. the freeze-dried powder is added to microcapsule materials and made into microcapsules through air suspension treatment; and 4. the microcapsules are mixed with oligosaccharides, vitamins and the like and then are made into a synbiotics pharmaceutical composition. By directly replenishing human intestines with Bifidobacterium and lactobacillus acidophilus, and by simultaneously providing prebiotics for ensuring that beneficial bacteria after entering intestines can be activated rapidly and proliferate, the product adjusts and improves intestinal micro-ecosystem, so as to achieve the aims of regulating organism immunity, delaying senility, inhibiting tumors, regulating blood lipid and improving intestines and stomach. A preparation method of the product can solve the technical problem that the prior probiotics medicine is difficult to keep the stability of probiotics at normal temperature and unstable under acidic conditions, and provides a pharmaceutical composition which can be stably stored at normal temperature.
Description
Technical field: [0001] The invention relates to an intestinal microecological regulator, which belongs to the category of microecological preparations. The microecological regulator is a preparation synthesized with probiotics and their metabolites and other accelerators that can adjust the microecological balance, improve the health level of the host or improve its health status. According to the composition of microecological preparations, it can be divided into three types: probiotics, prebiotics, and synbiotics. The present invention is a synbiotic, which uses one or more bifidobacteria and one It is prepared by combining one or more than one kind of prebiotics and vitamins after fermenting one or more kinds of intestinal beneficial bacteria separately or in combination. This product directly supplements Bifidobacteria and Lactobacillus acidophilus in the human intestinal tract, and at the same time provides prebiotics to enable the rapid activation and proliferation of ...
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