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Double braid nerve trachea and preparation method thereof

A nerve conduit and double-layer braiding technology is applied in the field of biomedical materials and tissue engineering, which can solve the problems of increasing the distance from the bridging defect of the nerve conduit to nerve regeneration, high brittleness, and easy to break and collapse, so as to help guide the growth of nerves. , the effect of improving the compression performance and improving the mechanical properties

Active Publication Date: 2012-11-07
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current problem of this material is its high brittleness, and it is easy to break and collapse when the tube wall is thin
[0008] On this basis, braided nerve conduits still have obvious deficiencies in increasing the distance that the nerve conduit can bridge defects and improving the quality and speed of nerve regeneration.

Method used

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  • Double braid nerve trachea and preparation method thereof
  • Double braid nerve trachea and preparation method thereof
  • Double braid nerve trachea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A double-layer braided nerve guide is composed of an outer tube wall made of polyglycolide-lactide braided and an inner tube wall made of polyglycolide-lactide fluffy parallel yarns.

[0024] The above-mentioned double-layer braided nerve guide is prepared by the following method: braiding polyglycolide-lactide yarn on the mandrel to form the outer tube wall; setting at 90°C for 2 minutes, cleaning with absolute ethanol, and setting at 90°C for 1 minute The outer tube wall made of polyglycolide-lactide is withdrawn from the mandrel, immersed in 2.5wt% chitosan slurry for 30 minutes, dried naturally, and freeze-dried at -50°C for 2 hours; The inner tube wall made of polyglycolide-lactide fluffy parallel yarns is penetrated into the gap left after the mandrel is taken out.

Embodiment 2

[0026] A double-layer braided nerve guide is composed of an outer tube wall made of polyglycolide-lactide braided and an inner tube wall made of polyglycolide-lactide fluffy parallel yarns.

[0027]The above-mentioned double-layer braided nerve guide is prepared by the following method: braiding polyglycolide-lactide yarn on the mandrel to form the outer tube wall; setting at 105°C for 5 minutes, cleaning with absolute ethanol, and setting at 100°C for 2 minutes The outer layer tube wall that polyglycolide-lactide is braided is withdrawn from the mandrel, dipped in 3wt% chitosan slurry for 40 minutes, dried naturally, and freeze-dried at -40 ℃ for 3 hours; The inner tube wall composed of polyglycolide-lactide fluffy parallel yarns penetrates into the void left after the mandrel is taken out.

Embodiment 3

[0029] A double-layer braided nerve guide is composed of an outer tube wall made of polyglycolide-lactide braided and an inner tube wall made of polyglycolide-lactide fluffy parallel yarns.

[0030] The above-mentioned double-layer braided nerve guide is prepared by the following method: braiding polyglycolide-lactide yarn on the mandrel to form the outer tube wall; setting at 100°C for 3.5min, cleaning with absolute ethanol, and setting at 95°C 1.5min; The outer tube wall made of polyglycolide-lactide was withdrawn from the mandrel, immersed in 2.8wt% chitosan slurry for 35 minutes, dried naturally, and freeze-dried at -45°C for 2.5 minutes. Hours; the inner tube wall made of polyglycolide-lactide fluffy parallel yarns is penetrated into the gap left after the mandrel is taken out.

[0031] The performance test of the double-layer braided nerve guide of embodiment 1-3 is as follows:

[0032] 1. Measurement and comparison of porosity: The concept equivalent to porosity is "re...

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Abstract

The invention provides a double-layer knitting nerve duct having the characteristics that the double-layer knitting nerve duct consists of an outer layer tube wall knitted by polyglycollide-lactide and an inner layer tube wall made from polyglycollide-lactide fluffy parallel yarns, and also provides a method for preparing the double-layer knitting nerve duct having the characteristics that the method comprises the following steps of: knitting polyglycollide-lactide yarns on a core bar; forming the polyglycollide-lactide yarns for 2 and 5 minutes at a temperature of between 90 and 105 DEG C, cleaning the polyglycollide-lactide yarns with anhydrous alcohol, and forming the polyglycollide-lactide yarns for 1 and 2 minutes at a temperature of between 90 and 100 DEG C; taking down a polyglycollide-lactide knitting layer from the core bar, dipping the polyglycollide-lactide knitting layer for 30 and 40 minutes in 2.5 and 3 weight percent of chitosan serum to naturally dry and freeze-dry thepolyglycollide-lactide knitting layer for 2 and 3 hours at a temperature of between 50 below zero and 40 DEG C; and inserting the polyglycollide-lactide fluffy parallel yarns to a clearance which is reserved after the core bar is taken out. The double-layer knitting nerve duct has the advantages of long-distance bridging defect, good quality and fast speed for nerve regeneration and good mechanical property.

Description

technical field [0001] The invention relates to a double-layer braided nerve guide and a preparation method thereof, belonging to the technical field of biomedical materials and tissue engineering. Background technique [0002] Nerve conduits are prefabricated tubular structures made of biological or non-biological materials to guide the growth of damaged nerves. It bridges between nerve stumps and is used to repair nerve damage. At present, the biodegradable absorbing materials used for artificial nerve conduits at home and abroad are mainly polylactic acid (PLA), chitosan (chitosan), collagen (collagen), polyglycolic acid (PGA), polyphosphazenes (polyphosphazenes) and their copolymerization. The reason is that these materials have a wide range of sources and are cheap; they are biodegradable and have no toxic effect on nerve tissue. In addition, with the in-depth research on the cellular and molecular mechanisms of peripheral nerve regeneration, people gradually realized...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/12A61L29/06
Inventor 陈南梁孙丹丹张佩华王文祖沈尊理郯志清
Owner DONGHUA UNIV