Podophyllotoxin external-use formulation prescription for treating pointed condyloma and herpes genitalis, dosage form series and preparation method

Abstract

The invention discloses a podophyllotoxin preparation formula for external use for the treatment of condyloma acuminatum and genital herpes, a series of formulations and a preparation method, and belongs to the field of pharmacy. The weights or the volumes of all the ingredients of the formula of 100ml of the podophyllotoxin preparation for external use are as follows: 0.5g of podophyllotoxin, 20ml-80ml of main solvent, 1ml-3ml of penetration enhancer 1, 0.5g-2.5g of penetration enhancer 2, 20ml-80ml of cosolvent and 0.03-0.5g of preservative. The podophyllotoxin preparation for external use has the advantages that the types and the amount of excipients and the proportion of main drugs are reasonable, the drug administration is carried out by a liniment, a spray or other formulations which are applicable to the external use, the main drug can be rapidly absorbed by the horny layer and the epidermis, the efficacy is significant, the local toxicity or side effects are small, the skin acute toxicity is very low, and the podophyllotoxin preparation has no irritation and weak allergy and does not hinder the skin normal functions; the podophyllotoxin preparation has no systemic toxicityor side effects, thereby being safe and effective. The preparation prepared by the formula has the advantages of good appearance, moderate viscosity, easy coating, spraying drug administration, feasible process, controllable quality, simple preparation process, and suitability for industrial batch production.

Description

technical field [0001] The invention relates to a prescription, a series of dosage forms and a preparation method of podophyllotoxin external preparations for treating condyloma acuminata and genital herpes, specifically, a preparation prescription, a series of external dosage forms and preparations for treating condyloma acuminatum and genital herpes with podophyllotoxin as an active ingredient The method belongs to the field of pharmacy. Background technique [0002] Genital warts are genital venereal diseases caused by human papillomavirus (HPV) infection. The number of patients with genital warts has increased nearly 10 times in the past 15 years. According to my country's sexually transmitted disease detection report, the genital HPV detection rate is 30.69 / 100,000, and its incidence rate ranks second in sexually transmitted diseases, second only to gonorrhea (Xu Wenyan. Prevention and treatment of sexually transmitted diseases. Shanghai: Second Military Medical Univer...

AI Technical Summary

Problems solved by technology

[0006] Podophyllotoxin has stable physical and chemical properties, but is insoluble in water. The main solvent used in the tincture is high-concentration ethanol, which causes the preparation to have strong irritation to the vulva mucosa, which not only brings pain to the patient, but also directly affects the medication. And there are safety problems in production and transportation

Ointment is mainly inconvenient to use, and the drug cannot be absorbed quickly after application. After a certain period of administration, the drug matrix attached to the surface of the mucous membrane must be washed off, and it also has certain mucous membrane irritation.

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