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Chinese medicinal composition as well as preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve problems such as decreased sperm motility, ICSI failure, sperm-egg fusion and decreased fertilization ability

Inactive Publication Date: 2012-05-30
SHANGHAI INST OF PLANNED PARENTHOOD RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many studies have shown that ROS production in semen, decreased sperm motility, sperm-egg fusion and decreased fertilization ability can also lead to ICSI failure

Method used

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  • Chinese medicinal composition as well as preparation method and application thereof
  • Chinese medicinal composition as well as preparation method and application thereof
  • Chinese medicinal composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0147] Preparation method of pharmaceutical composition

[0148] The pharmaceutical composition of the present invention can be prepared by conventional methods. In one embodiment, it includes the steps:

[0149] (1) Mix the necessary components or their extracts to obtain a mixture. The necessary components are (a) 15-90 parts by weight containing a traditional Chinese medicine that provides sperm motility energy, and the traditional Chinese medicine that provides sperm motility energy includes wolfberry Seeds, raspberries and dangshen; (b) 15-60 parts by weight of traditional Chinese medicine for strengthening adenosine triphosphate, said traditional Chinese medicine for strengthening adenosine triphosphate including Chinese yam; (c) 70-330 parts by weight of traditional Chinese medicine with antioxidant effect, said antioxidant The effective Chinese medicines include angelica, astragalus, white peony root, schisandra, dodder, rehmannia, cornus, tortoise shell, turtle shell, Shou...

Embodiment 1—3

[0169] Preparation of pharmaceutical composition

[0170]

[0171]

[0172] Mix the above-mentioned medicinal materials according to the formula amount. The first water addition is the total weight of the medicinal materials (g)×10ml, and the simmer is 40-50 minutes; the second water addition is the total weight of the medicinal materials (g)×6ml, and the simmer is 30-35 minutes. . Each dose is decocted twice, and after mixing, the pharmaceutical composition (decoction) of the present invention is obtained in a total of about 300 ml.

Embodiment 4

[0174] Pharmacodynamic test of pharmaceutical composition

[0175] 1. Materials and methods

[0176] 1.1 Research objects and groups

[0177] Selected from March 2005 to March 2007, infertile patients with severe oligozoospermia (non-obstructive spontaneous ejaculation) who were treated at Shanghai Family Planning Research Institute of Shanghai Fudan University School of Medicine and Shanghai Ruijin Hospital Reproductive Medicine Center 155 example. The patients were divided into two groups according to the different treatment methods:

[0178] 1. ICSI group (n=77), because of the prevention of ovarian hyperstimulation (OHSS), 5 patients gave up the transplant cycle, and 2 of the 72 patients experienced severe ovarian hyperstimulation;

[0179] 2. ICSI+Chinese medicine group (n=82). Because of the prevention of ovarian hyperstimulation (OHSS), 4 patients gave up the transplant cycle. 78 patients in the transplant cycle did not have severe ovarian hyperstimulation. The general informa...

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PUM

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Abstract

The invention discloses a medicinal composition, which comprises Chinese medicinal materials 30-99.9% of the total weight of the composition, and pharmaceutically acceptable carries in balancing amount. The Chinese medicinal materials include the following Chinese traditional medicines by weight: (a) 15-90 parts of Chinese medicinal materials for providing sperms motion energy, (b) 15-60 parts ofChinese medicinal materials for strengthening adenosine triphosphate, (c) 70-330 parts of Chinese medicinal materials for providing antioxidation effect, (d) 10-50 parts of Chinese medicinal materials for promoting sperms generation, (e) 10-40 parts of Chinese medicinal materials for regulating internal secretion, and (f) 20-80 parts of Chinese medicinal materials for invigorating qi and strengthening spleen. The invention also discloses a preparation method and an application thereof.

Description

Technical field [0001] The present invention relates to a traditional Chinese medicine composition, and more specifically, to a traditional Chinese medicine composition or dietary supplement for treating infertility and a preparation method thereof. Background technique [0002] According to a survey by the World Health Organization (WHO), 15% of couples of childbearing age in the world have infertility problems; 8%-22% are entirely attributable to men, and 21%-38% are related to both spouses, so it can be considered that about 50% The infertility factor involves men. About 1 / 10 of couples in China have infertility, and the male factor is about 40%. [0003] Since the 20th century, due to environmental pollution, the spread of sexually transmitted diseases, excessive smoking, drug abuse, and the abuse of hormonal drugs, male fertility has declined significantly worldwide. Studies have shown that the causes of male infertility include endocrine diseases, testicular spermatogenesis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61K36/8969A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P15/08A61K35/56A61K35/586
Inventor 张慧琴施惠娟宣文虎赵洪鑫贾晓峰张文静冯云张爱军
Owner SHANGHAI INST OF PLANNED PARENTHOOD RES
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