Self-sealing residual compressive stress graft for dialysis

A technique of grafting and radial compression, which is applied in the direction of human tubular structure devices, blood vessels, etc., and can solve the problem of destroying the progress of hemodialysis

Inactive Publication Date: 2009-03-11
HEMOSPHERE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These access failures disrupt the progress of routine hemodialy

Method used

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  • Self-sealing residual compressive stress graft for dialysis
  • Self-sealing residual compressive stress graft for dialysis
  • Self-sealing residual compressive stress graft for dialysis

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Detailed description of the preferred embodiment

[0049] Studies have shown that graft failure from local stenosis at the venous end of AV grafts is mainly due to intimal hyperplasia, non-compliance between graft and autogenous vein anastomosis, and turbulence at the anastomosis site. Kanterman RY et al "Dialysis accessgrafts:Anatomic location of venous stenosis and results of angioplasty." Instead of venous anastomosis, a catheter is used to direct blood into the venous system to avoid these incentives. We have developed a vascular access system that removes venous anastomosis in AV shunts using catheter elements at the venous end and synthetic graft elements that are anastomosed to the artery in a standard manner. We believe that such a system should eliminate or reduce venous hyperplasia, which is the biggest cause of AV shunt failure.

A. Vascular Access System (VAS)

[0050] Although these devices can be constructed as a single-piece integrated device, it is also possible to...

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Abstract

Vascular access systems for performing hemodialysis are disclosed. Some embodiments relate to vascular access grafts (250) comprising an instant access or self-sealing material (254) reinforced with expanded PTFE (252) to resist stretching of the instant access material (254) and thereby resist leakage associated with stretching or bending. The graft may comprise two end segments (260, 262) comprising ePTFE (252) without the instant access material (254) to allow easier anastomosis of the graft (250) to veins and arteries. The graft (250) may have a unibody design or have modular components that may be joined together to create a graft with customized length or other features. One or more sections of the graft (296) may also be cut or trimmed to a custom length.

Description

Background of the invention [0001] In the United States, approximately 400,000 people have end-stage renal disease and require long-term hemodialysis. By creating an arteriovenous (AV) anastomosis connecting a vein to an artery to create a high flow shunt or fistula, a permanent vascular puncture site for performing hemodialysis can be created. The vein can connect directly to the artery, but it takes 6 to 8 weeks for the venous portion of the fistula to mature enough to provide sufficient blood flow for hemodialysis. Moreover, due to anatomical factors, not all patients are suitable for direct anastomosis. Other patients may require the use of artificial graft material to provide a puncture site between the arterial and venous systems. Expanded polytetrafluoroethylene (ePTFE) is the preferred material, although many of the materials used to make artificial blood vessels for arterial replacement have also been attempted for dialysis punctures. Reasons for this include ePTFE...

Claims

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Application Information

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IPC IPC(8): A61F2/06
Inventor 贾德森·A·赫里希罗伯特·J·津波尔克里斯托弗·H·波特
Owner HEMOSPHERE
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