Use of C60 polyhydroxy derivates in preventing and treating related disease of mitochondria damage

A mitochondrial, multi-purpose technology, applied in the fields of biology and pharmacy, can solve problems such as ineffectiveness
CN101396372AInactive Publication Date: 2009-04-01SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI +1
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Publication Date
2009-04-01
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention belongs to the biological and medical field and discloses an application of a C60 or C60 polyhydroxy derivative in preparing a combination for preventing and remedying the related diseases of mitochondrial injury (such as neurodegenerative disease or radiation sickness). The invention constructs a cellular model and an animal model with the related diseases of the mitochondrial injury, demonstrates the excellent efficacy of the C60 or C60 polyhydroxy derivative for preventing and remedying the related diseases of the mitochondrial injury and provides an effective approach for developing multifunctional drugs with mitochondria as a target point accordingly.
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Description

technical field

[0001] The present invention belongs to the field of biology and pharmacy, more specifically, the present invention relates to C 60 The use of the polyhydroxy derivatives in the prevention and treatment of diseases related to mitochondrial damage. Background technique

[0002] Mitochondria are special organelles that widely exist in various eukaryotic cells, have circular DNA, and can replicate independently. It is not only the main place for the body to consume oxygen and produce ATP, but also has a variety of other extremely important physiological functions, including the production of reactive oxygen species such as superoxide anion, the regulation of cellular redox potential and signal transduction, the regulation of cell apoptosis and gene expression, etc. . As the regulatory center of cell metabolic network and signal transduction network, mitochondria have attracted increasing attention due to their important roles in growth, development, metabolism...

Claims

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