Technique for preparing florfenicol soluble powder

Abstract

The invention discloses florfenicol and a preparation process for compound recipe soluble powder thereof. The preparation process mainly comprises the following steps: taking 5+-0.5 grams of florfenicol, evenly mixing the florfenicol with 5-10 grams of polyethylene glycol 6000, grinding or crushing the mixture, adding oral glucose or lido powder into the mixture till the total weight reaches 100+-3 grams, screening the mixture through a No.4 sieve, packaging the mixture and obtaining the compound recipe soluble powder. The process has the advantages that: the process is simpler and quicker than an enclosing technology or a fusion eutectic technology and also has cost lower than that of the enclosing technology or the fusion eutectic technology.

Description

technical field [0001] The invention relates to a medicine, in particular to a florfenicol soluble powder. Background technique [0002] Florfenicol is a special-purpose chloramphenicol antibiotic for animals. It was developed by the American Schefing-Hough Company in the late 1970s in order to seek better chloramphenicol derivatives. Its antibacterial activity against sensitive bacteria is comparable to that of chloramphenicol. Similar to thiamphenicol, but still sensitive to bacteria resistant to chloramphenicol and thiamphenicol, such as Escherichia coli, Klebsiella, Pasteurella hemolyticus, Staphylococcus aureus, Actinobacillus pleuropneumoniae and Salmonella typhi, etc. Florfenicol was registered by the US FDA in 1996, and the trade names are Florocol and Nuflox respectively. Because chloramphenicol has serious adverse reactions of aplastic anemia, it has been banned in many countries for food animals. Therefore, florfenicol has broad application prospects in the pre...

AI Technical Summary

Problems solved by technology

Although its water solubility has been improved to a certain extent, there are still some problems in the use process, such as, in case of low temperature, the dissolution rate is slow or the prepared solution has florfenicol precipitated out; in the dissolution process, if In the presence of water, florfenicol will precipitate and the solution will become cloudy

Moreover, the use of special solvents increases production costs