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Arca extract enteric-coated capsules and manufacture method thereof

A technology of enteric-coated capsules and manufacturing methods, which is applied in the field of marine biological drugs, can solve problems such as unseen reports, and achieve the effects of prolonging survival time, stable effect, and simple manufacture

Active Publication Date: 2009-04-29
青岛海生肿瘤医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there have been no reports abroad about extracting effective pharmaceutical ingredients from marine cockles

Method used

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  • Arca extract enteric-coated capsules and manufacture method thereof
  • Arca extract enteric-coated capsules and manufacture method thereof
  • Arca extract enteric-coated capsules and manufacture method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Take 400kg of fresh cockles, wash them repeatedly with drinking water until the surface of the shells is free of mud, then wash them three times with purified water, remove the shells and take soft tissues, wash them with purified water until there is no blood stain, drain the water and weigh 88Kg of the net materials. Crush it with a masher, the particle size is 0.3cm, add purified water at a weight ratio (w / w) of 1:1.5, stir and extract with a mixer at a slow speed (60r / min) for 4 hours at 0-10°C, and put the extract in GQ105 Centrifuge in a high-speed tubular centrifuge (20000r / min) to remove slag, and freeze-dry to obtain 5.16Kg of freeze-dried powder with a yield of 5.87% by weight. The mixture is evenly mixed, vacuum-packed, and placed in a refrigerator. The freeze-dried powder is a light yellow-brown loose powder, with a drying loss of 3.0%, a nitrogen content of 75 mg / g, a glucose content of 32.9 mg / g, and a residue on ignition of 3.8% by weight.

Embodiment 2-4

[0103] In Example 2, take 4 kg of the freeze-dried powder of the clam extract from Example 1, add 0.08 kg of silicon dioxide and 0.04 kg of magnesium stearate, mix well, and pack into enteric-coated capsules to make 10,000 enteric-coated capsules of the extract of clams in total. The properties and characteristics of the dissolved capsules are shown in Table 9.

[0104] Table 9

[0105]

[0106] Embodiment 3 manufacturing process is identical with embodiment 2, and different embodiment 3 silicon dioxide is 0.08kg, magnesium stearate 0.08kg.

[0107] Embodiment 4 manufacturing process is identical with embodiment 2, and different embodiment 4 silicon dioxide is 0.12kg, magnesium stearate 0.08kg.

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Abstract

The invention relates to a clam extract enteric-coated capsule and a production method thereof. The clam extract enteric-coated capsule comprises a clam extract freeze-dried powder and an accessory, the weight of the accessory is 3 percent to 5 percent of the clam extract freeze-dried powder, wherein, the accessory is silicon dioxide and magnesium stearate, the weight ratio of which is 1:1 to 2:1. The clam extract freeze-dried powder is obtained by the steps of cleaning marine organism clams, removing shells, taking out soft bodies, mashing, extracting and freeze-drying. The clam extract enteric-coated capsule is rich in resources and easy to product, has high biological activity, can significantly improve the symptoms of malignancy, decreases myoma volume, enhances the quality of life, prolongs life cycle and can be applied to treating malignancy patients, such as lung cancer, liver cancer, renal carcinoma, carcinoma ventriculi, cervical carcinoma patients and the like and no obvious toxic and side effect is found.

Description

technical field [0001] The invention relates to the field of marine biopharmaceuticals, in particular to cockle extract enteric-coated capsules of marine organism cockle extracts and a manufacturing method thereof. Background technique [0002] The ocean covers 71% of the earth's surface area, and the total volume of seawater accounts for 97% of the total water volume of the earth. The effective area of ​​the unused ocean and coast is 5 to 10 times larger than that of the land. There are a lot of marine life in the ocean, and the resources are extremely rich. Moreover, marine organisms survive and develop in a specific environment of high salinity in the ocean. Compared with terrestrial organisms, they have unique characteristics and pharmacological activities. They are currently less polluted biological resources in the world and are new resources for obtaining biologically active substances. The development of marine biological drugs is more and more important. It has attr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/48A61P35/00A61K35/618
Inventor 陈守国王春波韩彦弢
Owner 青岛海生肿瘤医院
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