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Traditional Chinese medicine composition for treating diabetes

A composition and diabetes technology, applied in drug combination, metabolic disease, pharmaceutical formula, etc., can solve problems such as difficult blood sugar, insulin function can not be directly improved, slow action speed, etc., to improve quality, improve body immunity, and easy to scale up Effect

Inactive Publication Date: 2011-05-18
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although loquat leaf total triterpene acid alone can quickly restore insulin sensitivity, it cannot directly improve insulin function, and it is difficult to reduce blood sugar to normal levels with astragalus polysaccharide alone, and the action speed is slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Dried Radix Astragali 2kg medicinal material processed decoction pieces; reflux extraction with 20L boiling water, extraction 2 times, 1 hour each time; after cooling, filter, remove insoluble matter, clear filtrate through HZ-816 macroporous resin column, use 2-3 times to remove After washing with ionized water, the filtrate was spray-dried to obtain 150 g of off-white powder, namely astragalus polysaccharide with a content of 81%.

[0040] 30kg of dried loquat leaves were crushed through a 20-mesh sieve, heated to 70-85°C with 150L 80% ethanol for reflux extraction, extracted 3 times, 2 hours each time; filtered the extract, concentrated under reduced pressure to the extract; 2-5 times the weight of ethanol, heated to dissolve it; passed through MCI GEL column, eluted with 85% ethanol, collected in fractions, detected by TLC, evaporated to dryness to obtain 285g of light yellow to off-white powder, and determined the content of four kinds of triterpene acids by HPLC 8...

Embodiment 2

[0042] Dried Radix Astragali 2kg medicinal material processed decoction pieces; reflux extraction with 20L boiling water, extraction 2 times, 1 hour each time; after cooling, filter, remove insoluble matter, clear filtrate through D-140 macroporous resin column, use 2-3 times to remove After washing with ionized water, the filtrate was spray-dried to obtain 153 g of off-white powder, namely astragalus polysaccharide with a content of 82%.

[0043] 30kg of dried loquat leaves were crushed through a 20-mesh sieve, heated to 70-85°C with 120L 80% ethanol for reflux extraction, and extracted 3 times for 2 hours each time; the extract was filtered and concentrated under reduced pressure to extract; 2-5 times the weight of ethanol, heat it to dissolve; pass through the MCI GEL column, elute with 90% ethanol, collect in parts, detect by TLC, evaporate to dryness to get 315g of light yellow to off-white powder, and determine the content of four kinds of triterpene acids HPLC 86.5%, wh...

Embodiment 3

[0045] Dried Astragalus membranaceus 500g medicinal material processed decoction pieces; reflux extraction with 5L boiling water, extraction 2 times, 1 hour each time; after cooling, filter, remove insoluble matter, clear filtrate through D-145 macroporous resin column, use 2-3 times to remove After washing with ion water, the filtrate was spray-dried to obtain 51 g of off-white powder, namely astragalus polysaccharide with a content of 80.3%.

[0046] 30kg of dried loquat leaves were crushed through a 20-mesh sieve, heated to 70-85°C with 120L 90% ethanol for reflux extraction, extracted 3 times, each time for 2 hours; filtered the extract, concentrated under reduced pressure to extract; 2-5 times the weight of ethanol, heated to dissolve; passed through MCI GEL column, eluted with 80% ethanol, collected in parts, detected by TLC, evaporated to dryness to obtain 330g of light yellow to off-white powder, and determined the content of four kinds of triterpene acids HPLC 85.7%, ...

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Abstract

The invention provides a traditional Chinese medicine composition for curing diabetes. The composition is obviously superior to the extract of each single medical herb, is safe and has no obvious toxic and side effects. The composition is prepared by the following raw materials according to the parts by weight: 51-746 parts of astragalus root extract and 285-2700 parts of loquat leaf extract, wherein, the astragalus root extract is prepared via astragalus root through water extraction or alcohol extraction, the content of the polysaccharide (active component) is higher than 80 percent (weight percentage), the loquat leaf extract is prepared via loquat leaves through water extraction or alcohol extraction, and the active component thereof, i.e. the total triterpenic acid from the loquat leaves comprises the following components (weight percentage): 20-40 percent of maloic acid, 2-6 percent of oleanolic acid, 20-40 percent of corosolic acid and 8-20 percent of cralaegolic acid, wherein, the content of the total triterpenic acid from the loquat leaves is higher than 85 percent (weight percentage).

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition for treating diabetes, which uses traditional Chinese medicine extracts as active components. Background technique: [0002] The total triterpene acids of loquat leaf extract contain four kinds of triterpene acids: ursolic acid, oleanolic acid, corosolic acid and maslinic acid. Astragalus extract contains astragalus polysaccharides. There are literatures that taking loquat leaf extract or astragalus extract alone to treat diabetes can effectively control blood sugar levels. Although loquat leaf total triterpene acid alone can quickly restore insulin sensitivity, it cannot directly improve insulin function. It is difficult to reduce blood sugar to normal level with astragalus polysaccharide alone, and the action speed is slow. Invention content: [0003] The object of the present invention is to provide a traditional Chinese medicine composition for treating diabetes, which has rem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61P3/10
Inventor 邓小宽杨放姚洁
Owner CHENGDU UNIV
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