32results about How to "Excellent pharmacodynamic activity" patented technology

The invention provides a medicinal composition for treating rhinitis. The medicinal composition is prepared from the following raw materials in parts by weight: 5-15 parts of magnolia flower essential oil, 2-8 parts of centipeda minima essential oil, 1-5 parts of mint essential oil, 2-8 parts of agastache rugosa essential oil, 2-8 parts of wild chrysanthemum essential oil, and 1-5 parts of cassia twig essential oil. The invention further provides a preparation method and application of the composition. The study results show that the medicinal composition has a good therapeutic effect on chronic rhinitis and allergic rhinitis, is precise and appropriate in compatibility, and obviously superior to the medicinal composition with a different formula in pharmacological activity; meanwhile, the medicinal composition is not required to be orally taken or injected, so that the patient compliance is better and a novel choice is provided for clinical medication.

The invention provides a food, a health product or a pharmaceutical composition with an effect of protecting liver. The raw materials comprise the following components in parts by weight: 0.5-1.5 parts of cape jasmine fruit, 1-2 parts of dandelion, 0.5-1 part of hawthorn, 1 part of lotus leaf and 0.5-1 part of semen cassiae. The research proves that the composition can obviously improve various indexes of chemical liver injury, has good effects of protecting liver and lowering transaminase and is precise and appropriate in compatibility, a synergistic effect is achieved, and the pharmacodynamics activity is obviously superior to that of each single raw material.

The present invention provides a periploca forrestii schltr extract preparation method, which comprises: (1) taking a periploca forrestii schltr herb, crushing, extracting with ethanol with a volume ratio of more than 90%, and drying the extract to obtain an ethanol concrete; (2) taking the ethanol concrete, adding water to disperse, extracting by sequentially adopting petroleum ether and ethyl acetate, mixing the ethyl acetate layer, and removing the solvent to obtain an ethyl acetate concrete; and (3) taking the ethyl acetate concrete, adding to a silica gel column, sequentially carrying out gradient elution by adopting chloroform and methanol according to a ratio of (10-5):(0-1), collecting the elution segment at a ratio of chloroform to methanol of 5:1, removing the solvent, and drying to obtain the periploca forrestii schltr extract. The present invention further provides the extract prepared through the method, and a use thereof. The periploca forrestii schltr extract has characteristics of good anti-inflammatory activity, good anti-rheumatoid arthritis activity, significantly increased efficacy activity superior to other extraction sites, and no significant rebound after drug withdrawal, and provides a new selection for clinical medication.

The invention provides food, a health-care product or pharmaceutical composition for sleep aiding. The food, the health-care product or the pharmaceutical composition comprises raw materials in parts by weight as follows: 1-1.5 parts of cape jasmine fruits, 1-2 parts of lily bulbs, 1-1.5 parts of poria cocos, 0.5-1 part of alpiniae oxyphyllae fructus, 3 parts of oysters and 1-1.5 parts of lotus seeds. The research indicates that the composition can obviously improve the sleep effect and is precisely and appropriately matched, a synergistic effect is played, and the pharmacological activity is obviously better than those of the single raw materials.

The invention provides a Tongmai oral liquid raw material extract, which is characterized in that the ratio of Tongmai oral liquid raw materials is as follows: salvia miltiorrhiza: radix puerariae: ligusticum wallichii=1: 1: 1, and in the raw material extract, the weight ratio of the active ingredients is as follows: tanshinol: puerarin: ferulic acid: tanshinone IIA=(0.9-1.3): (1.0-1.3): (1.0-1.2): 1.0. According to the invention, alcohol and water are taken as solvents to extract the Tongmai oral liquid raw materials together; although the extraction efficiency for the active ingredients is not as good as extraction by using 60% alcohol, the raw material extract prepared by the method is obviously superior to the previous preparation process and the 60% alcohol extract with the highest active ingredient content in pharmacological activity; an unexpected technical effect is achieved; and the Tongmai oral liquid raw material extract is advantageous for the patients suffering cardiovascular and cerebrovascular diseases.

The invention discloses a solid drink with stomach nourishing and spleen tonifying effects and a preparation method of the solid drink. The solid drink is prepared from 20-40 parts of morchella, 20-40parts of hericium erinaceus, 10-30 parts of flos lablab album, 10-20 parts of semen raphani and 5 parts of maltodextrin. The preparation method of the solid drink comprises the steps as follows: themorchella, the hericium erinaceus, the flos lablab album and the semen raphani are subjected to extraction and concentration respectively, extracts are mixed and uniformly mixed with the maltodextrin,wet granulation, low-temperature drying and packaging are conducted, and the solid drink with stomach nourishing and spleen tonifying effects is obtained. The prepared solid drink has the excellent stomach nourishing and spleen tonifying effects, has high effective ingredient content and is easy to absorb and utilize after being orally taken, components of the solid drink are properly matched andplay a synergistic effect, and the pharmaceutical activity is obviously superior to that of each raw material.

The invention provides a traditional Chinese medicine composition for treating cerebrovascular disease and preparation and application thereof, belonging to the field of medicine. The traditional Chinese medicine composition provided by the invention comprises 23-43% of angelica sinensis, 23-43% of cinnamon and balance of ginseng in percentage by weight. The invention also provides the preparation and pharmaceutical application of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention can be used for treating cerebrovascular disease, in particular ishemic stroke, has small dose, good effect and no side effect, and is a safe and effective traditional Chinese medicine preparation.

A provided pharmaceutical composition for treating diabetes is a preparation prepared from the following bulk drugs in parts by weight: 10-60 parts of coptis, 10-60 parts of radix asparagi, 10-60 parts of rehmannia glutinosa, 10-60 parts of dark plum, 5-20 parts of ginseng and 2-12 parts of cinnamomum cassia. The invention also provides a preparation method and application of the pharmaceutical composition. Tests show that: the pharmaceutical composition is precise and appropriate in compatability, is capable of effectively reducing blood sugar, is substantially more excellent in drug effect activity than classic prescription Lianmeitang and Jiaotai pill, and helps to provide a new choice for clinical medication for treating diabetes.

The invention discloses an amidoxime compound and application thereof to preparation of medicines for inhibiting cancer cell proliferation, and relates to the field of medicinal chemistry. The amidoxime compound provided by the invention has capacity of inhibiting the cancer cell proliferation, so that an aim of treating cancers is achieved. The amidoxime compound particularly has excellent activity of inhibiting the cancer cell proliferation of human cutaneous melanoma cells (A375), human lung cancer cells (A549), human gastric carcinoma cells (MGC80-3), and human hepatoma cells (HepG2). The structure of the amidoxime compound is as shown in the specification. In the formula, n is 1-6, and R refers to alkyl or substituted alkyl.

The invention provides a traditional Chinese medicine composition for curing diabetes. The composition is obviously superior to the extract of each single medical herb, is safe and has no obvious toxic and side effects. The composition is prepared by the following raw materials according to the parts by weight: 51-746 parts of astragalus root extract and 285-2700 parts of loquat leaf extract, wherein, the astragalus root extract is prepared via astragalus root through water extraction or alcohol extraction, the content of the polysaccharide (active component) is higher than 80 percent (weight percentage), the loquat leaf extract is prepared via loquat leaves through water extraction or alcohol extraction, and the active component thereof, i.e. the total triterpenic acid from the loquat leaves comprises the following components 20-40 parts of maloic acid, 2-6 parts of oleanolic acid, 20-40 parts of corosolic acid and 8-20 parts of cralaegolic acid, wherein, the content of the total triterpenic acid from the loquat leaves is higher than 85 percent (weight percentage).

The present invention relates to a quinazoline derivative and its preparation method and application in medicine, specifically the present invention relates to a quinazoline derivative or its stereoisomer, hydrate, metabolite, solvate, pharmaceutical The acceptable salts, co-crystals or prodrugs relate to their preparation methods, their pharmaceutical compositions and their use in medicine, especially as EGFR/HER2 dual-target inhibitors.

The invention provides a Smilax scobomocaulis polysaccharide extractive with polysaccharide content greater than 20% w/w. The invention also provides a preparation method and application of the extractive. The invention also provides a composition based on the extractive and for the treatment of pelvic inflammation The research of the invention discovers that the Smilax scobomocaulis polysaccharide has good effects of resisting inflammation, promoting blood circulation to remove blood stasis and enhancing immune function, and has a good therapeutic effect on pelvic inflammatory diseases.

The invention provides a traditional Chinese medicine compound type antibiotic-free immunity-enhancing feed additive and a preparation method thereof. The traditional Chinese medicine compound type antibiotic-free immunity-enhancing feed additive is prepared from the following raw material components: 10 to 20 parts of fructus ligustri lucidi crude extract, 10 to 20 parts of folium artemisiae argyi crude extract, 5 to 10 parts of rhizoma belamcandae crude extract, 5 to 10 parts of algal polysaccharide soluble powder, 5 to 10 parts of tourmaline powder and 50 to 80 parts of auxiliary materials; the preparation method comprises the following steps: weighing the raw materials and mixing to prepare powder; preparing a granular preparation by adopting dry-process granulation and arranging a dry-process granulator. The traditional Chinese medicine compound type antibiotic-free immunity-enhancing feed additive provided by the invention has the beneficial effects that a plurality of components with an immunity-enhancing effect are compounded according to a certain ratio, wherein the fructus ligustri lucidi crude extract, the folium artemisiae argyi crude extract, the rhizoma belamcandae crude extract and the algal polysaccharide soluble powder are extracted and prepared according to a special technology; after the powder in the formula is uniformly mixed, the powder is prepared into granules by adopting a dry-process granulation technology; an experiment result shows that various immunity indexes of pig bodies are improved through the compound formula and the pharmacological activity is obviously better than that of each single raw material; the effect of the dry-process granulation is stronger than that of a common granulation method.

The invention discloses a paulownia flower-containing animal immunity enhancing medicinal composition. The composition is a preparation prepared from Radix Astragali and paulownia flowers. The invention also discloses a preparation method of the medicinal composition, and a use of the medicinal composition. The medicinal composition combining Radix Astragali with the paulownia flowers has a good immunity enhancing effect, has better medicine effect activity than single Radix Astragali and paulownia flowers, and also has the advantages of small medicine variety number, low cost and excellent clinic application prospect. The medicinal composition can be combined with antibiotics to effectively treat porcine reproductive and respiratory syndrome, so a new choice is provided for clinic medicine use.

The invention provides an veterinary drug combination for treating livestock and poultry respiratory disease syndrome. The veterinary drug combination is a preparation prepared by the following medical raw materials by weight: 8-27 parts of echinacea, 24-35 parts of loquat leaf, 9-28 parts of herba andrographitis and 3-9 parts of cubeba. The invention further provides a preparation method and a purpose of the veterinary drug combination. The livestock and poultry respiratory disease syndrome, such as porcine pneumonia and gallinaceous viral influenza can be effectively treated by the drug combination. The curative rate is high, and the pharmacological activity is obviously superior to that of a commercial available drug. A new choice is provided for clinic drugs.