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Traditional Chinese medicine composition for treating diabetes

A composition and traditional Chinese medicine technology, applied in the directions of drug combination, metabolic diseases, pharmaceutical formulations, etc., can solve the problems of slow action speed, inability to directly improve insulin function, difficult blood sugar, etc., and achieve easy amplification, improve body immunity, and improve quality. Effect

Inactive Publication Date: 2009-05-13
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although loquat leaf total triterpene acid alone can quickly restore insulin sensitivity, it cannot directly improve insulin function, and it is difficult to reduce blood sugar to normal levels with astragalus polysaccharide alone, and the action speed is slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Dried astragalus 2kg medicinal materials are processed into decoction pieces; reflux extraction with 20L boiling water, extraction twice, 1 hour each time; after cooling, filter, remove insoluble matter, clear filtrate through HZ-816 macroporous resin column, use 2-3 times to remove The ionized water was washed, and the filtrate was spray-dried to obtain 150 g of off-white powder, namely astragalus polysaccharide with a content of 81%.

[0040] 30kg of dried loquat leaves were crushed and passed through a 20-mesh sieve, heated to 70-85°C with 150L 80% ethanol for reflux extraction, and extracted 3 times for 2 hours each time; the extract was filtered out and concentrated under reduced pressure to extract; 2-5 times the weight of ethanol, heated to dissolve; passed through MCI GEL column, eluted with 85% ethanol, collected in parts, detected by TLC, evaporated to dryness to obtain 285g of pale yellow to off-white powder, the content of four triterpenoid acids was determin...

Embodiment 2

[0042] Dried astragalus 2kg medicinal materials are processed into decoction pieces; reflux extraction with 20L boiling water, extraction twice, 1 hour each time; after cooling, filter, remove insoluble matter, clear filtrate through D-140 macroporous resin column, use 2-3 times to remove The ionized water was washed, and the filtrate was spray-dried to obtain 153 g of off-white powder, namely astragalus polysaccharide with a content of 82%.

[0043] 30kg of dried loquat leaves were pulverized and passed through a 20-mesh sieve, heated to 70-85°C with 120L 80% ethanol for reflux extraction, and extracted 3 times for 2 hours each time; the extract was filtered out and concentrated under reduced pressure to extract; 2-5 times the weight of ethanol, heated to dissolve; passed through MCI GEL column, eluted with 90% ethanol, collected in parts, detected by TLC, evaporated to dryness to obtain 315g of pale yellow to off-white powder, the content of four triterpenoid acids was determ...

Embodiment 3

[0045] 500g dried medicinal materials of Astragalus are processed into decoction pieces; reflux extraction with 5L boiling water, twice, 1 hour each time; after cooling, filter, remove insoluble matter, clear filtrate through D-145 macroporous resin column, use 2-3 times to remove The ionized water was washed, and the filtrate was spray-dried to obtain 51 g of off-white powder, namely astragalus polysaccharide with a content of 80.3%.

[0046] 30kg of dried loquat leaves were pulverized and passed through a 20-mesh sieve, heated to 70-85°C with 120L 90% ethanol for reflux extraction, and extracted 3 times for 2 hours each time; the extract was filtered out and concentrated under reduced pressure to extract; 2-5 times the weight of ethanol, heated to dissolve; passed through MCI GEL column, eluted with 80% ethanol, collected in parts, detected by TLC, evaporated to dryness to obtain 330g of pale yellow to off-white powder, and the content of four triterpenoid acids was determine...

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Abstract

The invention provides a traditional Chinese medicine composition for curing diabetes. The composition is obviously superior to the extract of each single medical herb, is safe and has no obvious toxic and side effects. The composition is prepared by the following raw materials according to the parts by weight: 51-746 parts of astragalus root extract and 285-2700 parts of loquat leaf extract, wherein, the astragalus root extract is prepared via astragalus root through water extraction or alcohol extraction, the content of the polysaccharide (active component) is higher than 80 percent (weight percentage), the loquat leaf extract is prepared via loquat leaves through water extraction or alcohol extraction, and the active component thereof, i.e. the total triterpenic acid from the loquat leaves comprises the following components 20-40 parts of maloic acid, 2-6 parts of oleanolic acid, 20-40 parts of corosolic acid and 8-20 parts of cralaegolic acid, wherein, the content of the total triterpenic acid from the loquat leaves is higher than 85 percent (weight percentage).

Description

Technical field: [0001] The present invention relates to a traditional Chinese medicine composition for treating diabetes with traditional Chinese medicine extracts as active ingredients. Background technique: [0002] Loquat leaf extract contains four triterpene acids: ursolic acid, oleanolic acid, corosolic acid and maslinic acid. Astragalus extract contains astragalus polysaccharides. There are literatures that loquat leaf extract or astragalus extract can be used alone to treat diabetes, which can effectively control blood sugar levels. Although the total triterpenoid acid of loquat leaves can restore insulin sensitivity quickly, it cannot directly improve insulin function. It is difficult to reduce blood sugar to normal levels with astragalus polysaccharide alone, and the effect is slow. Invention content: [0003] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating diabetes, which has a remarkable effect of con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P3/10
Inventor 邓小宽杨放姚洁
Owner CHENGDU UNIV
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