Extraction process of raw medicinal materials of exterior syndrome-relieving particles for children

An extraction process and granule technology, which is applied in plant raw materials, drug combinations, pharmaceutical formulas, etc., can solve the problems of low transfer rate of baicalin and low content of baicalin, and achieve the effect of improving transfer rate and increasing utilization rate

Active Publication Date: 2015-03-04
SICHUAN GOODDOCTOR PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the inventors have found that the transfer rate of baicalin in the products prepared by the existing method is low, resulting in a low content of baicalin in the final product

Method used

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  • Extraction process of raw medicinal materials of exterior syndrome-relieving particles for children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 300g of honeysuckle, 250g of forsythia, 250g of fried burdock, 300g of dandelion, 300g of baicalin, 150g of windproof, 150g of perilla leaf, 100g of nepeta ear, and 150g of pueraria radix; The above hot water is decocted again, and the second time can be directly boiled with cold water for extraction. The amount of water added is 10 times and 8 times the amount of crude drug, and the extraction time is 2.5 hours and 1.5 hours respectively. Concentrate under reduced pressure at ℃ to a relative density of 1.05 (measured at 40 ℃), add ethanol until the alcohol content reaches 50% v / v, let stand, and use the supernatant for later use; take the precipitate and add ethanol until the alcohol content reaches 60% v / v v Then extract at 60°C, filter the extract while it is hot (the temperature of the extract is 50°C), and recover the solvent from the obtained filtrate and supernatant to obtain the extract.

Embodiment 2

[0026] Weigh 300g of honeysuckle, 250g of forsythia, 250g of fried burdock, 300g of dandelion, 300g of baicalin, 150g of windproof, 150g of perilla leaf, 100g of nepeta ear, and 150g of kudzu root; Hot water, the second time you can directly add cold water to boil for extraction, the amount of water added is 10 times and 8 times the amount of crude drug, the extraction time is 2.5 hours and 1.5 hours respectively, filter, combine the extracts, and concentrate the extracts under reduced pressure at 65 °C To a relative density of 1.08 (measured at 40°C), add ethanol until the alcohol content reaches 50% v / v, let it stand, and use the supernatant for later use, add ethanol to the precipitation until the alcohol content reaches 65% v / v, and then store at 70°C Extraction, the extract is filtered while it is hot (the temperature of the extract is 50°C), and the obtained filtrate and supernatant are recovered from the solvent to obtain the extract.

Embodiment 3

[0028] Weigh 300g of honeysuckle, 250g of forsythia, 250g of fried burdock, 300g of dandelion, 300g of baicalin, 150g of windproof, 150g of perilla leaf, 100g of nepeta ear, and 150g of kudzu root; Hot water, the second time you can directly add cold water to boil for extraction, the amount of water added is 10 times and 8 times the amount of crude drug, the extraction time is 2.5 hours and 1.5 hours respectively, filter, combine the extracts, and concentrate the extracts under reduced pressure at 70°C To a relative density of 1.06 (measured at 40°C), add ethanol until the alcohol content reaches 50% v / v, let it stand, and use the supernatant for later use, add ethanol to the precipitation until the alcohol content reaches 70% v / v, and then store at 80°C Extraction, the extract is filtered while it is hot (the temperature of the extract is 50°C), and the obtained filtrate and supernatant are recovered from the solvent to obtain the extract.

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Abstract

The invention provides an extraction process of raw medicinal materials of exterior syndrome-relieving particles for children. The invention further provides an extract prepared by the extraction process. The preparation method provided by the invention can be used for not only effectively improving the baicalin transfer rate, but also accidentally improving the transfer rate of other effective components such as chlorogenic acid and puerarin, so that the utilization ratio of medicinal materials is greatly increased, thereby, providing guarantee for preparing medicines with more excellent pharmacodynamics activity.

Description

technical field [0001] The invention relates to a new extraction process of Xiao'erjiebiao granule raw medicinal materials and the prepared extract. Background technique [0002] Xiaoer Jiebiao Granules are prepared from 300g of honeysuckle, 250g of forsythia, 250g of burdock (stir-fried), 300g of dandelion, 300g of skullcap, 150g of windproof, 150g of perilla leaf, 100g of nepeta panicle, 150g of kudzu root and 1g of artificial bezoar. It can disperse the lungs and relieve the exterior, clear away heat and detoxify, and is used for colds caused by exogenous wind-heat in children. Symptoms include fever and aversion to wind, headache and cough, nasal congestion, runny nose, and sore throat. [0003] The current preparation method of Xiao'er Jiebiao Granules is as follows: the above ten flavors, forsythia, perilla leaves, and nepeta ears extract volatile oil, and the distilled aqueous solution is collected in another device; Two times, the first time is 2.5 hours, the second...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/634A61K9/16A61P11/00
Inventor 耿福能吴宇吴桃清杨勤张杨
Owner SICHUAN GOODDOCTOR PHARMA GRP
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