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A kind of pharmaceutical composition for treating diabetes and its preparation method and use

A composition and technology for diabetes, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problem of no significant influence on body weight and insulin level, and achieve the effect of lowering blood sugar and good compatibility

Inactive Publication Date: 2015-10-21
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lu Xiong et al. found that Jiaotai Pills (Huanglian: Cinnamon = 1:1) had the effect of lowering blood sugar and serum triglycerides in the rat model of type 2 diabetes fed with high-sugar and high-fat diet combined with low-dose streptozotocin injection. However, it has no significant effect on body weight and insulin levels, and its mechanism may be related to the improvement of insulin sensitivity (Lu Xiong, et al., Experimental Research on the Hypoglycemic Effect of Jiaotai Pills, Liaoning Journal of Traditional Chinese Medicine, Volume 34, Issue 9, 2007)

Method used

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  • A kind of pharmaceutical composition for treating diabetes and its preparation method and use

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Effect test

Embodiment 1

[0020] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0021] Take 30g of Coptis chinensis, 6g of cinnamon, 15g of ginseng, 30g of asparagus, 30g of rehmannia glutinosa, and 30g of black plum; add 8 times the amount of water and decoct 3 times, each time for 0.5h, combine the decoction, filter, and after the filtrate is concentrated, add appropriate amount Soluble starch, granulated.

Embodiment 2

[0022] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0023] Take 30g of Coptis chinensis, 6g of cinnamon, 15g of ginseng, 30g of asparagus, 30g of rehmannia glutinosa, and 30g of ebony plum; add 8 times the amount of water and decoct 3 times, each time for 0.5h, combine the decoction, filter, concentrate the filtrate, and dry, Add an appropriate amount of microcrystalline cellulose, mix well, and pack into capsules.

Embodiment 3

[0024] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0025] Take 35g of Coptis chinensis, 4g of cinnamon, 12g of ginseng, 25g of asparagus, 25g of rehmannia glutinosa, and 25g of ebony plum, add 80% v / v ethanol for reflux extraction twice, and use the alcohol extract for later use; Combine the water decoction; recover ethanol from the ethanol extract, combine with the water decoction, concentrate, add appropriate soluble starch, and granulate to obtain granules.

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Abstract

A provided pharmaceutical composition for treating diabetes is a preparation prepared from the following bulk drugs in parts by weight: 10-60 parts of coptis, 10-60 parts of radix asparagi, 10-60 parts of rehmannia glutinosa, 10-60 parts of dark plum, 5-20 parts of ginseng and 2-12 parts of cinnamomum cassia. The invention also provides a preparation method and application of the pharmaceutical composition. Tests show that: the pharmaceutical composition is precise and appropriate in compatability, is capable of effectively reducing blood sugar, is substantially more excellent in drug effect activity than classic prescription Lianmeitang and Jiaotai pill, and helps to provide a new choice for clinical medication for treating diabetes.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes and its preparation method and application. Background technique [0002] Diabetes is a combination of sugar, protein, fat, water, and A series of metabolic disorder syndromes such as electrolytes, the pathological mechanism is mainly insulin secretion defect or insulin action defect. The main features are hyperglycemia, diabetes, polyuria, polydipsia, polyphagia, weight loss, and fatigue. Diabetes is mainly divided into four categories, namely type 1 diabetes, type 2 diabetes, other specific types of diabetes and gestational diabetes. In recent years, diabetes has become the third major disease that seriously endangers human health after tumors and cardiovascular and cerebrovascular diseases. The number of people with diabetes worldwide is increasing year by year. In 2008, there were 43 million diabetic patients in my country, with an increase of about 1.2 million people e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8965A61P3/10
Inventor 钟森涂翔
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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