Low-temperature preparation method for American cockroach extract

A technology of Periplaneta americana and its extract, which is applied in the field of low-temperature preparation of Periplaneta americana extract, achieving good market application prospects

Inactive Publication Date: 2015-05-20
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

The production process of Kangfuxin liquid is reflux extraction with a certain concentration of ethanol for several hours, during which it is immersed in water at 70°C, and in the sterilization stage, it is boiled with liquid medicine and sterilized at a high temperature above 115°C for 30 minutes. All these high-temperature links are enough to cause protein, peptide Therefore, using the whole process of low-temperature production of Kangfuxin Liquid to preserve the protein and peptide components is of great significance to the expression of the curative effect of Kangfu Liquid. This study intends to use the relevant experimental indicators of animal gastric ulcer models as a reference to study The curative effect of the original Kangfuxin liquid and the Kangfuxin liquid produced at low temperature was compared. There is no relevant literature report in this study

Method used

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  • Low-temperature preparation method for American cockroach extract
  • Low-temperature preparation method for American cockroach extract
  • Low-temperature preparation method for American cockroach extract

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preparation example Construction

[0058] Preparation of defatted decoction pieces of Periplaneta americana:

[0059] The Periplaneta americana is sorted and put into a hopper, and the Periplaneta americana oil is separated from the worm body at a temperature of 30-60° C. and a pressure of 10-50 MPa, and the Periplaneta americana oil and defatted Periplaneta americana are collected respectively.

[0060] Take the defatted Periplaneta americana, use 8 times the amount of 90% ethanol for flash extraction for 5 minutes, add 5 times the amount of 90% ethanol to the dregs and continue the flash extraction for 3 minutes, filter, discard the dregs, combine the two extracts, and reduce the concentration below 50 ° C. Press to recover ethanol, concentrate to the extract with a liquid medicine ratio of 1:1.0 to 1.2, add purified water 10 times the amount of the extract to the extract, mix evenly and fully, let the liquid stand for more than 20 minutes, cool to room temperature, and Set aside for 12 to 16 hours, filter, c...

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Abstract

The invention provides a low-temperature preparation method for an American cockroach extract. The method comprises the following steps: (1) taking American cockroaches or degreased American cockroaches, adding a solvent, extracting at low temperatures and combining an extraction liquid; and (2) recovering the solvent from the extraction liquid at a reduced pressure and concentrating to obtain the American cockroach extract. According to the novel process for extracting the American cockroach extract provided by the invention, the active ingredients of the American cockroaches are effectively retained, and the pharmacodynamics activity of the obtained extract is superior to the product which is prepared in the prior art, so that the method has a relatively good market application prospect.

Description

technical field [0001] The invention relates to a low-temperature preparation method of an extract of Periplaneta americana. Background technique [0002] Kangfuxin liquid is recorded in the nineteenth volume of traditional Chinese medicine preparations of the Ministry of Health's drug standard WS3-B-3672000. It is a liquid preparation prepared from the alcohol extract of Periplaneta americana. Oral administration is used for stagnation of blood stasis, gastric pain and bleeding, gastric and duodenal ulcers, and adjuvant treatment of yin deficiency pulmonary tuberculosis and tuberculosis. For external use on the wounds of gold sores, trauma, ulcers, fistulas, burns, scalds, and bedsores. It is still used for the accumulation of lumps in the abdomen, malnutrition in children, beriberi edema, boils, swollen poison and insect bites. [0003] Periplaneta americana is used as animal medicine, and its main chemical components are proteins, peptides, amino acids, nucleotides, phe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P1/04
Inventor 王达宾张帅杰苏柘僮熊永爱邹俊波
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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