Nano lycorine chloride microcapsule latex and preparation method thereof

A technology of lycorine hydrochloride and nano-microcapsules, which is applied in the fields of emulsion delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as slow release, and achieve the effect of reducing strong effects and prolonging release time
CN101450041AActive Publication Date: 2009-06-10HUABAO FLAVOURS & FRAGRANCES CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUABAO FLAVOURS & FRAGRANCES CO LTD
Publication Date
2009-06-10

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Abstract

The invention discloses a nano-scale lycorine hydrochloride microcapsule emulsion and preparing method thereof. The nano-scale lycorine hydrochloride microcapsule emulsion comprises a water phase II and a lycorine hydrochloride nano microcapsule dispersed in the water phase II, the particle diameter range of the lycorine hydrochloride nano microcapsule is 5-100 nm; the lycorine hydrochloride nano microcapsule is composed of a water phase I and an oil phase, the water phase is packaged in the oil phase. The preparing method comprises (1) adding the water phase I into the oil phase to form pre-emulsifiable solution under 50000rmp-20000rmp high speed shearing condition; (2) mixing the pre-emulsifiable solution and the water phase II to obtain a premixing liquid under the stirring condition; (3) performing high-pressure homogeneity for the premixing liquid one-four times to obtain the nano-scale lycorine hydrochloride microcapsule emulsion under 100-200 MPa.
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Description

technical field

[0001] The invention relates to the field of pharmacy, and discloses a nanometer microcapsule emulsion, in particular a nanoscale lycorine hydrochloride microcapsule emulsion and a preparation method thereof. Background technique

[0002] Since the 1990s, the research on pharmaceutical dosage forms and preparations has entered the era of drug delivery systems. New drug release systems have become an important development direction in the field of pharmacy, among which the controlled release technology of drugs, especially the research on timed release technology, localized release technology and fixed rate release technology has become a research hotspot and difficulty in the field of medicine.

[0003] In the oral sustained and controlled release drug delivery system, many drugs with strong first-pass effects and some drugs with very short or long half-lives have been made into sustained or controlled release preparations, which mainly include some sustained...

Claims

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