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Nano lycorine chloride microcapsule latex and preparation method thereof

A technology of lycorine hydrochloride and nano-microcapsules, which is applied in the fields of emulsion delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as slow release, and achieve the effect of reducing strong effects and prolonging release time

Active Publication Date: 2009-06-10
HUABAO FLAVOURS & FRAGRANCES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, lycorine hydrochloride is generally administered by intravenous injection or subcutaneous injection. The administration method is relatively simple. The release of lycorine hydrochloride in the body has a drug peak effect and cannot be released slowly and stably.

Method used

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  • Nano lycorine chloride microcapsule latex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 18 grams of lycorine hydrochloride and 1.8 grams of gellan gum, and add them to 60 grams of water under stirring (stirring rate 50 rpm), until the lycorine hydrochloride and gellan gum are completely dissolved in water to obtain the water phase I.

[0033] Take by weighing 129.6 gram of weighting agent sucrose acetate isobutyrate (SAIB, U.S. Eastman company), 5.4 gram of antioxidant BHT, 27 gram of surfactant I Span60 (UK Croda company), under stirring situation (stirring speed 100rpm), Disperse and dissolve in 250 g of olive oil to obtain an oily phase.

[0034] Add the water phase I to the oil phase under high shear (10000rmp) to form a pre-emulsion.

[0035] Weigh 64 grams of surfactant II Tween 40 (Croda, UK), 32 grams of emulsifier gum arabic, add to 840 grams of water, stir and disperse evenly (stirring speed 50 rpm), to obtain water phase II.

[0036] The pre-emulsion was added to the aqueous phase II under stirring (stirring rate 50 rpm) to obtain a pre-m...

Embodiment 2

[0038] Weigh 8 grams of lycorine hydrochloride and 1 gram of gellan gum, and add them to 89 grams of water under stirring (stirring rate 100 rpm), until the lycorine hydrochloride and gellan gum are completely dissolved in water to obtain the water phase I.

[0039] Take by weighing 7 gram weight-increasing agent SAIB (U.S. Eastman company), 2 gram antioxidant BHA, 7 gram surfactant I Span80 (UK Croda company), under stirring situation (stirring speed 50rpm), disperse and dissolve in 234 gram palm oil , an oily phase was obtained.

[0040] Add the water phase I to the oil phase under high shear (5000rmp) to form a pre-emulsion.

[0041] Weigh 10 grams of surfactant II potassium oleate and 32 grams of emulsifier Purity Gum 1773 (National Starch Co.) into 750 grams of water, stir and disperse evenly (stirring speed 200 rpm), to obtain aqueous phase II.

[0042]The pre-emulsion was added to the aqueous phase II under stirring (stirring rate 1000 rpm) to obtain a pre-mixture. In...

Embodiment 3

[0044] Take by weighing 8 grams of lycorine hydrochloride, 0.8 gram of xanthan gum and 1 gram of gellan gum, and under stirring (stirring speed 500 rpm), join in 89 grams of water until lycorine hydrochloride and gellan gum are completely dissolved in water , to obtain the aqueous phase I.

[0045] Take by weighing 80 gram weight-increasing agent SAIB (U.S. Eastman company), 0.7 gram antioxidant BHA, 7 gram surfactant I Span85 (UK Croda company), under stirring situation (stirring rate 1000rpm), disperse and dissolve in 200 gram sunflower seeds oil to obtain an oily phase.

[0046] Add the water phase I to the oil phase under high shear (20000rmp) to form a pre-emulsion.

[0047] Take by weighing 10 gram surfactant II brij-35 (U.S. Amresco company), 22 gram emulsifier Purity Gum 1773 (National Starch Co.), 10 gram emulsifier guar gums join in 750 gram water, stir and disperse evenly (stirring speed 500rpm), to obtain the aqueous phase II.

[0048] The pre-emulsion was added...

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Abstract

The invention discloses a nano-scale lycorine hydrochloride microcapsule emulsion and preparing method thereof. The nano-scale lycorine hydrochloride microcapsule emulsion comprises a water phase II and a lycorine hydrochloride nano microcapsule dispersed in the water phase II, the particle diameter range of the lycorine hydrochloride nano microcapsule is 5-100 nm; the lycorine hydrochloride nano microcapsule is composed of a water phase I and an oil phase, the water phase is packaged in the oil phase. The preparing method comprises (1) adding the water phase I into the oil phase to form pre-emulsifiable solution under 50000rmp-20000rmp high speed shearing condition; (2) mixing the pre-emulsifiable solution and the water phase II to obtain a premixing liquid under the stirring condition; (3) performing high-pressure homogeneity for the premixing liquid one-four times to obtain the nano-scale lycorine hydrochloride microcapsule emulsion under 100-200 MPa.

Description

technical field [0001] The invention relates to the field of pharmacy, and discloses a nanometer microcapsule emulsion, in particular a nanoscale lycorine hydrochloride microcapsule emulsion and a preparation method thereof. Background technique [0002] Since the 1990s, the research on pharmaceutical dosage forms and preparations has entered the era of drug delivery systems. New drug release systems have become an important development direction in the field of pharmacy, among which the controlled release technology of drugs, especially the research on timed release technology, localized release technology and fixed rate release technology has become a research hotspot and difficulty in the field of medicine. [0003] In the oral sustained and controlled release drug delivery system, many drugs with strong first-pass effects and some drugs with very short or long half-lives have been made into sustained or controlled release preparations, which mainly include some sustained...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/36A61K47/44A61K31/437A61P9/00A61P25/28
Inventor 谷向春张福军罗昌荣
Owner HUABAO FLAVOURS & FRAGRANCES CO LTD
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