Method for preparing medical lycorine emulsion

A technology of lycorine and emulsion, which is applied in the directions of non-active ingredient medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve the problems of slow release and the like

Inactive Publication Date: 2010-10-13
陈倩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, lycorine is generally administered by intravenous injection or subcutaneous injection. The administration method is relatively simple, and the release of lycorine in the body has a drug peak effect, and cannot be released slowly and stably.

Method used

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  • Method for preparing medical lycorine emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Weigh 16 grams of lycorine and 1.6 grams of xanthan gum, and add them into 60 grams of distilled water while stirring, until the lycorine and xanthan gum are completely dissolved in the distilled water to obtain the water phase 1.

[0021] (2) Weigh 118.3 grams of weighting agent SAIB, 4.4 grams of antioxidant BHT, and 28 grams of surfactant Span60, and disperse and dissolve them in 250 grams of soybean oil under stirring to obtain an oil phase.

[0022] (3) Add the water phase 1 into the oil phase under high-speed shear (10000 rpm) to form a pre-emulsion.

[0023] (4) Weigh 8 grams of surfactant Myrij-45 and 32 grams of emulsifier gum arabic into 820 grams of distilled water, stir and disperse evenly to obtain water phase 2.

[0024] (5) under stirring, add the pre-emulsion to the water phase 2 to obtain the pre-mixture;

[0025] (6) Inject the pre-mixed liquid into the M-110EH high-pressure micro-fluidic nano-dispersion equipment, and homogenize twice under the p...

Embodiment 2

[0028] (1) Weigh 8 grams of lycorine and 0.8 grams of carrageenan, and add them to 92 grams of distilled water while stirring, until the lycorine and carrageenan are completely dissolved in the distilled water to obtain the water phase 1.

[0029] (2) Weigh 8 grams of weighting agent EG, 20 grams of antioxidant BHA, and 7 grams of surfactant Span85, and disperse and dissolve them in 250 grams of salad oil under stirring to obtain an oil phase.

[0030] (3) Add the water phase 1 into the oil phase under high-speed shear (5000 rpm) to form a pre-emulsion.

[0031] (4) Weigh 10 grams of surfactant brij-30 and 32 grams of emulsifier Purity Gum 1773 (manufactured by National Starch & Chemical Co.) into 750 grams of distilled water, stir and disperse evenly to obtain water phase 2.

[0032] (5) under stirring, add the pre-emulsion to the water phase 2 to obtain the pre-mixture;

[0033] (6) Inject the pre-mixed liquid into the M-110EH high-pressure micro-fluidic nano-dispersion equ...

Embodiment 3

[0035] (1) Weigh 8 grams of lycorine and 1 gram of guar gum, and add them into 92 grams of distilled water while stirring until the lycorine and guar gum are completely dissolved in the distilled water to obtain the water phase 1.

[0036] (2) Weigh 80 grams of weighting agent SAIB, 0.7 grams of antioxidant BHA, and 7 grams of surfactant Span80, and disperse and dissolve them in 200 grams of olive oil under stirring to obtain an oil phase.

[0037] (3) Add the water phase 1 into the oil phase under high-speed shear (20000 rpm) to form a pre-emulsion.

[0038] (4) Take by weighing 10 grams of surfactant Myrij-45, 22 grams of emulsifier Purity Gum 1773 (produced by Nationalstarch & chemical Co), 10 grams of emulsifier guar gum and join in 750 grams of distilled water, stir and disperse evenly to obtain water phase 2 .

[0039] (5) under stirring, add the pre-emulsion to the water phase 2 to obtain the pre-mixture;

[0040] (6) Inject the pre-mixed liquid into the M-110EH high-...

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Abstract

The invention discloses a method for preparing medical lycorine emulsion, which comprises the following steps: 1), dissolving the lycorine and a hydrophilic colloid in distilled water to obtain a water phase 1; 2) dissolving a weighting agent, an antioxidant and a surfactant 1 in vegetable oil to obtain an oil phase; 3) under a condition of high-speed shearing, adding the water phase 1 into the oil phase to form pre-emulsion; 4) dissolving a surfactant 2 and an emulsifier in distilled water to obtain an oil phase 2; 5) under a stirring condition, adding the pre-emulsion into the water phase 2 to obtain a premix; and 6) injecting the premix into high-pressure internal jet nano dispersion equipment for high-pressure homogeneity to obtain emulsion. The obtained lycorine emulsion can realize stable release.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and mainly relates to a preparation method of medical lycorine stable emulsion. Background technique [0002] Since the 1990s, the research on pharmaceutical dosage forms and formulations has entered the era of drug delivery systems. New drug release systems have become an important development direction in the field of pharmacy, among which the controlled release technology of drugs, especially the research on timed release technology, localized release technology and fixed rate release technology has become a research hotspot and difficulty in the field of medicine. In the oral sustained and controlled release drug delivery system, many drugs with strong first-pass effects and some drugs with very short or long half-lives have been made into sustained or controlled release preparations, which mainly include the direct preparation of some sustained release microparticles or microcapsules Sus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/4745A61K47/44A61K47/36A61P29/00A61P31/04A61P35/00A61P9/00A61P25/28A61P21/00
Inventor 陈倩
Owner 陈倩
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