Antimicrobial therapy for bacterial infections

A technology of microorganisms and microbial infections, applied in biochemical equipment and methods, anti-infective drugs, anti-bacterial drugs, etc.

Inactive Publication Date: 2009-06-17
RGT UNIV OF CALIFORNIA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Third, traditional therapies impose a "live-or-die" challenge on bacteria, whereby there is strong selective pressure to develop resistance to antimicrobial agents
Finally, many existing antibiotics have a very broad spectrum of activity, with the side effect of clearing the composition of many normal bacterial flora, leading to undesired complications such as Clostridium difficile colitis or secondary fungal infections (such as Candida spp. )

Method used

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  • Antimicrobial therapy for bacterial infections
  • Antimicrobial therapy for bacterial infections
  • Antimicrobial therapy for bacterial infections

Examples

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Embodiment

[0257] The biosynthetic pathway of S. aureus carotenoids includes the essential functions of the genes crtM and crtN encoding dehydrosqualene synthase and dehydrosqualene desaturase, respectively. To probe the bioactivity of the S. aureus pigment, isogenic mutants of golden yellow human clinical isolates were generated by allelic substitution of crtM. The ΔCrtM mutant is achromatic and lacks the characteristic three-peak profile of wild-type carotenoids at wavelengths of 440, 462 and 491 nM. No differences were observed between WT and ΔCrtM S. aureus in growth rate, stationary phase density, surface charge, buoyancy or hydrophobicity. S. aureus crtM and crtN together are sufficient to produce 4,4'-di-apostreptrin. To obtain functional assays, both genes were expressed in non-pigmented S. pyogenes, a human pathogen associated with a disease spectrum similar to S. aureus. When transformed with the pCrtMN plasmid, S. pyogenes acquired a yellow pigmentation with spectral charact...

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Abstract

The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy.

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C. §119 to U.S. Provisional Patent Application Serial No. 60 / 800,564, filed May 12, 2006, which is hereby incorporated by reference. Related application PCT / US06 / 14486 is hereby incorporated by reference. [0003] Statement Regarding Federally Funded Research [0004] This application was funded in part by grant numbers AI048694, GM50694, GM65307, and GM073216 awarded by the National Institutes of Health. The Government may have certain rights in this invention. Background technique [0005] Ogston (1881) used the genus Staphylococcus to describe grape-like bacteria (staphylo = grape, Greek) collected from the pus of surgical abscesses. Shortly thereafter, Rosenbach (1884) isolated the pathogen in pure culture and proposed that it The species name of Staphylococcus aureus (S.aureus) (golden, Latin). [0006] After entering the 1970s, the era of antimicrobial therapy has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N57/10A61K31/66
CPCA61K31/496C07F9/113A61K2039/522C12N9/1085A61K45/06A61K2300/00A61K38/14A61K9/0014A61K9/127C07F9/098C07F9/3808A61K31/4174A61K31/662A61P31/00A61P31/04A61P43/00Y02A50/30C07C15/00B05B1/14
Inventor 维克托·尼日特乔治·Y·刘埃里克·欧菲尔德宋永乘
Owner RGT UNIV OF CALIFORNIA
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