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A biosensor solid substrate with integrated temperature control and a method to make the same

A biosensor and substrate technology, applied in chemical instruments and methods, thermometers, laboratory containers, etc., can solve the problems of unrealized precision, control temperature and its distribution, etc.

Inactive Publication Date: 2009-06-17
KONINK PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this prior art does not achieve precise control of the temperature and its distribution on the surface of the solid substrate of the biosensor

Method used

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  • A biosensor solid substrate with integrated temperature control and a method to make the same
  • A biosensor solid substrate with integrated temperature control and a method to make the same
  • A biosensor solid substrate with integrated temperature control and a method to make the same

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Experimental program
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Effect test

Embodiment 1

[0164] The polymer of Figure 1 was dissolved in xylene and printed at specific locations on the nylon biosensor membrane using an inkjet printer. Subsequently, the solvent was evaporated. Then, the transition temperature from scattering to transparent was observed at about 80° C. using a charge-coupled device (CCD) camera.

Embodiment 2

[0166] In another example, 65 parts by weight of a polymer (commercially available from Merck under the designation LCP93; degree of polymerization n+m≈40; smectic to isotropic transition at 97° C. according to Merck)

[0167]

[0168] with 35 parts by weight of ethoxylated bisphenol-A diacrylate (Sartomer 349, commercially available from Sartomer). Both materials have a similar refractive index of about 1.55, avoiding light scattering when the liquid crystal polymer LCP093 is heated above its liquid crystallinity transition temperature. For curing, the samples were blended with 2 parts by weight of photoinitiator (Irgacure 651 - Ciba Specialty Chemicals). The mixture forms a paste that can be printed on a biosensor substrate using a PDMS mold. By using a UV source PL10 lamp (Philips-365nm light, intensity 0.6mW·cm -2) for curing. When heated above 74 °C, the appearance of the samples changed from highly scattering to clear and transparent. The transition takes place at...

Embodiment 3

[0170] The liquid crystal molecules of Figure 2 were mixed with ethoxylated bisphenol-A diacrylate, and then printed at specific locations on the nylon biosensor membrane using an inkjet printer. The mixture was photopolymerized using UV light in the presence of a photoinitiator (2% by weight of Irgacure 651 commercially available from Ciba Specialty Chemicals). Then, the transition temperature from scattering to transparent was observed at 60-61 °C using a charge-coupled device (CCD) camera.

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Abstract

This invention provides a biosensor solid or hydrogel substrate comprising one or more temperature indicating agents, each of said one or more temperature indicating agents operating by changing its optical properties and being deposited in and / or at the surface of the biosensor solid or hydrogel substrate as one or more layers and / or spots.

Description

technical field [0001] The present invention relates to a sensor substrate, such as a solid or hydrogel substrate of a biosensor, for the analysis of a sample fluid presumed to contain one or more target analyte molecules, such as biological compounds. In particular, the invention allows cheap, fast and precise measurement of temperature and its distribution at the level of the solid substrate of the biosensor. The invention also relates to a biosensor device comprising a solid substrate of a biosensor with integrated temperature monitoring and / or control means. The biosensor substrates and devices incorporating them can be used as analytical and diagnostic tools in the fields of human and veterinary medicine. In particular, the present invention relates to a method of analyzing a sample fluid presumed to contain one or more analyte molecules, such as target biological compounds, which method can be used in molecular diagnostic tests, such as measuring the presence of infecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCG01K11/16B01L2300/0636B01L2300/0663B01L2200/147B01L3/508
Inventor D·J·布勒尔R·彭特曼R·库尔特E·佩特斯H·R·施塔伯特A·派里克A·科列斯尼琴科H·德科宁
Owner KONINK PHILIPS ELECTRONICS NV