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Figwort root dispensing granule as well as preparation method and quality control method thereof

A kind of Scrophulariaceae formula granules, the technology of Scrophulariaceae, applied in the directions of pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc., can solve problems such as difficulty in spectrum analysis

Active Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • Figwort root dispensing granule as well as preparation method and quality control method thereof
  • Figwort root dispensing granule as well as preparation method and quality control method thereof
  • Figwort root dispensing granule as well as preparation method and quality control method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: Radix Scrophulariae Formula Granules

[0037] Take 100kg of Scrophulariae decoction pieces, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.05- 1.10; the concentrated solution is preheated at 45°C, the inlet air temperature is 180°C, the material pump speed is 550 rpm, the outlet air temperature is 80°C, and the air delivery temperature is 45°C, and the spray-dried Scrophulariaceae is obtained; Add 0-5% of its own weight dextrin in the spray-dried ginseng powder; the spray-dried scrophulariaceae powder has a pressure of 5 MPa on the main roller, a pressure of 0.5 MPa on the side roller, a spindle speed of 400 rpm, and a feeding voltage of 5 MPa. Dry granulation under the condition of 120V to obtain 20-60 mesh Scrophulariaceae formula...

Embodiment 2

[0038] Embodiment 2: Radix Scrophulariae Formula Granules

[0039] Take 100kg of Scrophulariae decoction pieces, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.00— 1.05; the concentrated solution is preheated at 50°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray drying is obtained to obtain the spray-dried powder of Scrophulariaceae Radix Scrophulariae; Add 5-15% of its own weight of auxiliary material dextrin to the spray-dried powder; under the conditions that the pressure of the main pressure roller is 6MPa, the pressure of the side pressure roller is 0.4MPa, the spindle speed is 450 rpm, and the feeding voltage is 110V. Dry granulation ...

Embodiment 3

[0041] Embodiment 3: Radix Scrophulariae Formula Granules

[0042] Take 100kg of Scrophulariae decoction pieces, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.10- 1.15; the concentrate is preheated at 45°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray-dried Scrophulariaceae is obtained; Add 15-25% of its own weight of lactose to the ginseng spray-dried powder; the pressure of the main roller is 4MPa, the pressure of the side roller is 0.4MPa, the spindle speed is 500 rpm, and the feeding voltage is 130V. granules, 20-60 mesh Scrophulariae formula granules were obtained, and each gram of Scrophulariae formula granules was equivalent t...

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Abstract

The invention discloses a figwort prescription granule, a preparation method and a quality control method thereof. The prescription granule takes figwort decoction pieces as the raw materials and the figwort prescription granule is prepared through the process flows of twice water extraction, vaccum concentration, sponging drying, etc; 1g of the figwort prescription granule is equal to 3-5g of crude drug; the quality of both figwort decoction pieces and figwort prescription granule are identified by infrared fingerprint spectra. The figwort prescription granule of the invention has complete and advanced production process, specific and controllable quality control standard, scientific, advanced and fast detecting method related to the quality standard and strong operability. A great number of experiments, the prepared soup of the figwort prescription granule of the invention and the mixed simmered liquid of the classical prescription decoction pieces containing figwort have equal components, thus realizing the technique of full ingredient prescription granule and proving the rationality of the technique of the invention; furthermore, the invention applies the technology of infrared spectroscopy technology to the quality control of the traditional Chinese medicines, rapidly solving the primary problem in the macro quality control of the traditional Chinese medicines---the identification of the truth of the traditional Chinese medicines.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule and its preparation method and quality control method, in particular to a Scrophulariaceae formula granule and its preparation method and quality control method. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with water after ext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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