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A large scale method for the deoxofluorination of ketones

A fluorinated, industrial-scale technology for the large-scale production of compounds with geminal fluorine atoms that can address issues such as the absence of an effective and safe method for the deoxyfluorination of geminal difluoro compounds

Inactive Publication Date: 2009-08-12
BAYER SCHERING PHARMA OY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0019] None of the previously cited documents disclose an efficient and safe process for the deoxyfluorination of ketones for the industrial scale production of gem-difluoro compounds and there is a real need for such a process in the chemical industry

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  • A large scale method for the deoxofluorination of ketones
  • A large scale method for the deoxofluorination of ketones

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Embodiment Construction

[0047] According to the present invention, it is possible to figure 2 The deoxyfluorination of ketones for the production of gem-difluorides on an industrial scale is preferably carried out in a system of figure 2 There are three reaction systems (a), (b) and (c) arranged in parallel according to the specific form of the embodiment of the present invention in the system.

[0048] The reaction system (a) comprises at least one storage tank la for containing the eluting mixture, or, according to other forms of embodiment, the reaction system (a) comprises a storage tank containing a ketone and containing diethylaminosulfur trifluoride itself or A storage tank of solutions in organic solvents, which are continuously mixed to form an isolated mixture.

[0049] according to figure 2 , the reaction system (a) further includes a reaction chamber 3a, and the segregated mixture is continuously supplied into the reaction chamber 3a.

[0050] The flow of the eluting mixture to the ...

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Abstract

A method for the deoxofluorination of a ketone for the production of a geminal difluoride compound in an industrial scale comprising the following steps: - preparing an educt mixture comprising a ketone and a dialkylaminosulfur trifluoride, - letting flow the educt mixture into a reaction chamber of defined length, diameter and volume, with a flow path having a width perpendicular to the direction of the flow in the range of 1-10 mm, at a temperature of at least 75 DEG C up to 120 DEG C, preferably between 80 and 100 DEG C, to perform the deoxofluorination reaction and obtaining a product mixture - to quench the product mixture with a basic aqueous solution in a cooled reservoir vessel.

Description

technical field [0001] The present invention relates to a process for the large-scale production of compounds having geminal fluorine atoms, more particularly to the deoxofluorination of ketones involving the use of diethylaminosulfur trifluoride (DAST) and its analogs , to obtain a process for gem-difluoro compounds, which is carried out on an industrial scale. [0002] The invention also relates to a reaction system for the production of gem-difluoro compounds on an industrial scale and to the use of said reaction system for the deoxyfluorination of ketones with dialkylaminosulfur trifluoride. Background technique [0003] Fluorination is a common reaction step in which one or more fluorine atoms or fluorinated groups are added to a compound using reagents that serve as donors for the fluorine atoms or fluorinated groups. [0004] Various fluorinating reagents are known in the art in liquid or gaseous form, for example, fluorine in its elemental form, hydrofluoric acid, S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C17/18B01J14/00
Inventor K·洛维斯J·热斯莱R·森泽尔M·福莫勒C·芬克M·诺K·格特弗里德U·布德U·蒂尔
Owner BAYER SCHERING PHARMA OY
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