Application of T-2 toxin in the preparation of drugs for treating bone cancers and myeloproliferative disorder

A T-2, 1. T-2 technology, applied in the field of application of T-2 toxin in the preparation of drugs for the treatment of bone cancer and myelodysplasia

Active Publication Date: 2011-02-02
SHENZHEN ICARBONX INTELLIGENT PEPTIDE PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010]The current research on T-2 toxin is mainly focused on its toxicity and pathogenicity to animals, and the use of T-2 toxin in bone cancer and bone marrow hyperplasia The study of drugs for the treatment of abnormal syndrome has not been found to be reported

Method used

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  • Application of T-2 toxin in the preparation of drugs for treating bone cancers and myeloproliferative disorder
  • Application of T-2 toxin in the preparation of drugs for treating bone cancers and myeloproliferative disorder
  • Application of T-2 toxin in the preparation of drugs for treating bone cancers and myeloproliferative disorder

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with specific examples, and these examples are only for illustrating the present invention, and do not limit the scope of the present invention.

[0022] Test 1: In vitro inhibitory effect of T-2 toxin on multiple myeloma

[0023] 1.1 Animals

[0024] SCID mice, 6 weeks old, weighing about 20g, male and female

[0025] 1.2 Cell lines and antibodies

[0026] IL-6 dependent human multiple myeloma cell line XG7, stimulated gpl30mAb

[0027] 1.3 Leak detection in SCID mice

[0028] Blood was collected from the venous plexus of SCID mice after ELISA with a capillary tube, the serum was separated, and the IgG content in the mouse serum was detected by ELISA.

[0029] 1.4 Tumor cell culture

[0030] Human multiple myeloma cell line XG7 was cultured in RMPI-1640 containing 3 μg / ml IL-6 and 10% FCS, placed at 37°C,

[0031] 5%CO 2 in the cell culture incubator. One week before transplantation, add 5 μg / ...

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Abstract

The invention discloses a new use of T-2 toxin, that is, application of T-2 toxin in the preparation of drugs for treating bone cancers and myeloproliferative disorder, wherein the curative dose thereof is 0.1-20 mg / Kg (weight), preferably 0.5-8 mg / Kg (weight), during drug administration, the method comprises oral administration, intravenous injection, hypodermic injection and intramuscular injection. The invention establishes animal or cell models of multiple myeloma, osteosarcoma and myelodysplastic syndrome, and inspects the inhibition of the T-2 toxin on the tumors or tumor cells by injection or cell co-culture. The experiment shows that the T-2 toxin is capable of inhibiting the growth of tumor cells and has good killing effect on the bone cancers and myeloproliferative disorder.

Description

technical field [0001] The invention relates to the application of T-2 toxin in the preparation of medicines for treating bone cancer and myeloid hyperplasia. Background technique [0002] The etiology of bone tumors is still unknown. In the past, it was believed that injuries, especially chronic minor injuries and chronic infections, could cause bone tumors. In recent years, through experimental research, for example, Fujinaga used sarcoma virus to make a large number of mouse osteosarcoma models, Finkel used different types of isotopes and viruses to make osteosarcoma animal models, and some people used radioactive substances such as radium and strontium to make osteosarcoma animals Model. These pathogenic factors have been confirmed by many scholars. The onset age of bone tumors is 15-24 years old for males and 5-14 years old for females, which may be related to the time and duration of bone growth and endocrine development in different genders. [0003] Pathological t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/35A61P35/00A61P19/00
Inventor 厉保秋
Owner SHENZHEN ICARBONX INTELLIGENT PEPTIDE PHARM TECH CO LTD
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