Oral anti-allergy compound pharmaceutical composition

A composition and anti-allergic technology, applied in the directions of drug combinations, allergic diseases, active ingredients of heterocyclic compounds, etc., can solve the problems such as levocetirizine and mast cell membrane stabilizers that have not yet been found, and achieve the superiority of anti-allergic reactions , prolong the incubation period of asthma, inhibit the effect of rhinitis allergic symptoms

Active Publication Date: 2009-09-09
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Oral combination preparations using levocetirizine and mast cell membrane stabilizers have not been found

Method used

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  • Oral anti-allergy compound pharmaceutical composition
  • Oral anti-allergy compound pharmaceutical composition
  • Oral anti-allergy compound pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 Levocetirizine Ketotifen Tablets

[0017] formula:

[0018] Ingredient mg / composition

[0019] Levocetirizine 2.5

[0020] Starch 30.0

[0021] Lactose 70.0

[0022] Sodium carboxymethyl starch 5.0

[0023] 5% PVP K30 Solution Appropriate amount

[0024] Micronized silica gel 0.2

[0025] Magnesium Stearate 1.0

[0026] Ingredient mg / component

[0027] Ketotifen 0.5

[0028] Starch 10.0

[0029] Lactose 30.0

[0030] Sodium carboxymethyl starch 2.0

[0031] 5% PVP K30 Solution Appropriate amount

[0032] Micronized silica gel 0.1

[0033] Magnesium stearate 0.5

[0034] Preparation method:

[0035] Take the formula amount of levocetirizine, starch, lactose, sodium carboxymethyl starch, mix evenly, put it in a high-speed stirring granulator, add an appropriate amount of binder, granulate, sieve, and dry at 50-60°C , add an appropriate amount of micropowder silica gel and magnesium stearate, and set aside; take the formulated amount of ketot...

Embodiment 2

[0036] Embodiment 2 Levocetirizine Ketotifen Capsules

[0037] formula:

[0038] Ingredient mg / composition

[0039] Levocetirizine 5.0

[0040] Starch 50.0

[0041] Lactose 80.0

[0042] Sodium carboxymethyl starch 6.5

[0043] 5% PVP K30 Solution Appropriate amount

[0044] Micronized silica gel 0.3

[0045] Magnesium stearate 1.5

[0046] Ingredient mg / component

[0047] Ketotifen 1.0

[0048] Starch 15.0

[0049] Lactose 50.0

[0050] Sodium carboxymethyl starch 3.5

[0051] 5% PVP K30 Solution Appropriate amount

[0052] Micronized silica gel 0.2

[0053] Magnesium stearate 0.8

[0054] Preparation method:

[0055] Take the formula amount of levocetirizine, starch, lactose, sodium carboxymethyl starch, mix evenly, put it in a high-speed stirring granulator, add an appropriate amount of binder, granulate, sieve, and dry at 50-60°C , add an appropriate amount of micropowder silica gel and magnesium stearate, and set aside; take the formulated amount of keto...

Embodiment 3

[0056] Embodiment 3 levocetirizine tranilast capsules

[0057] formula:

[0058] Ingredient mg / composition

[0059] Levocetirizine 2.5

[0060] Tranilast 100

[0061] Starch 60.0

[0062] Lactose 90.0

[0063] Sodium carboxymethyl starch 6.0

[0064] 5% PVP K30 Solution Appropriate amount

[0065] Micronized silica gel 0.4

[0066] Magnesium stearate 1.5

[0067] Preparation method:

[0068] Get the levocetirizine, tranilast, starch, lactose, carboxymethyl starch sodium of formula quantity, mix, place high-speed stirring granulator, add appropriate amount of binder, granulate, sieve, in 50 Dry at ~60°C, add appropriate amount of micro-powdered silica gel and magnesium stearate, mix well and pack into capsules to obtain.

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PUM

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Abstract

The invention relates to an oral anti-allergy compound pharmaceutical composition, which contains levocetirizine and mast cell membrane stabilizer. The dosage forms of the composition comprise tablet, capsule, suspending agent, dry suspending agent, oral solution, granule, and the like. The oral medicament is applied to the treatment of allergic diseases such as urticaria, eczema, dermatitis, allergic rhinitis, skin pruritus, and the like.

Description

Technical field: [0001] The invention relates to an oral antiallergic compound pharmaceutical composition, in particular to an oral compound preparation of levocetirizine and a mast cell membrane stabilizer. Background technique: [0002] Antihistamines are the most commonly used drugs against allergic diseases. However, allergic diseases involve more than 50 kinds of inflammatory mediators, and its complexity makes it difficult for a single drug to have an effective effect. With extensive and in-depth research on various inflammatory cells and their mediators, it has been increasingly recognized that mast cells play a central role in the pathogenesis of allergic inflammation. Therefore, the combination of antihistamines and drugs related to the regulation of mast cells has a better effect. [0003] Some literatures have reported the topical compound preparation of antihistamines and drugs related to regulating mast cells, such as: Patent CN1104498 / 94103562 discloses a loc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K45/06A61K31/381A61K31/196A61K31/436A61K31/41A61K31/353A61P37/08
Inventor 况娇张琼虞忠徐芳媛李侠王凯向翠英唐叔棠彭芸胥俊艾国强
Owner CHONGQING HUAPONT PHARMA
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