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Application and preparing method of Chinese milkvetch seed extractive

A technology of extract and application, which is applied in the application and preparation field of the Vetch chinensis extract, and achieves the effects of reducing administration dosage, reasonable and simple process, and reducing urinary protein.

Active Publication Date: 2009-09-16
浙江金石亚药医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application and preparing method of Chinese milkvetch seed extractive
  • Application and preparing method of Chinese milkvetch seed extractive
  • Application and preparing method of Chinese milkvetch seed extractive

Examples

Experimental program
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Effect test

Embodiment 1

[0037] 2.5kg of milk vetch seeds, fried, crushed, sieved through a 10-mesh sieve, soaked in 60% ethanol for 2 hours, refluxed twice, 2 hours each time, filtered with 2 layers of medical gauze, combined filtrate, reduced pressure (-0.08 -0.10MPa) after recovering ethanol, extract with equal volume of petroleum ether, ethyl acetate and n-butanol three times respectively, recover the solvent under reduced pressure (-0.08-0.10MPa), dry in vacuum at 60°C, and place in a drying oven Activated carbon adsorbs residual n-butanol to obtain dry extract, which is crushed into fine powder for preservation.

Embodiment 2

[0039] 28kg of milk vetch seeds, fried, crushed, passed through a 10-mesh sieve, soaked in 60% ethanol with 6 times the amount, refluxed twice, 2 hours each time, filtered with 2 layers of medical gauze, combined filtrate, reduced pressure (-0.08- 0.10MPa) After recovering ethanol, use D101 macroporous adsorption resin to adsorb, wash the column with 6 times the amount of water and 7 times the amount of 30% ethanol, then elute with 9 times the amount of 70% ethanol, and finally wash the column with 95% ethanol to elute The liquid is decompressed (-0.08-0.10MPa) to recover the solvent, and dried in vacuum at 60°C to obtain a dry extract, which is crushed into fine powder for storage.

[0040] The relevant research results of the present invention are as follows:

[0041] One, the influence of each extraction component in embodiment 1 on Adriamycin nephropathy model rat

[0042] 1. Experimental animals: healthy SD rats, male, weighing 350±20 g, were purchased from Zhejiang Expe...

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Abstract

The invention discloses an application and preparing method of Chinese milkvetch seed extractive. Triterpenes, flavonoids and their glycosides as effective components are extracted out from Chinese milkvetch seed as raw material and used for reducing the urokinase protein and treating the nephrotic syndrome. Chinese milkvetch seed is extracted by the ethanol reflux extraction method, the solvent is recycled under decompression, the triterpenes, flavonoids and their glycosides are obtained after the macroporous polymeric adsorbent column chromatography or the n-butanol extraction separation. The Chinese milkvetch seed extractive has the functions of reducing the urokinase protein and treating the nephrotic syndrome, and can be taken for a long time without obvious noxious and side effect; the process is reasonable and simple, the effective components are remained, the dosage is reduced.

Description

technical field [0001] The invention relates to natural medicine technology, in particular to the use and preparation method of milk vetch seed extract. Background technique [0002] The kidney is an important organ of the five viscera, the innate foundation. Its function is to excrete the metabolites in the human body, reabsorb the useful components in the metabolites back into the body, and then discharge the waste produced - urine through the ureter and bladder. At the same time, the kidney is also a very important endocrine organ in the body, responsible for the production of erythropoietin, active vitamin D3, which promotes hematopoiesis, and the decomposition of insulin in the body. Once the kidney function is damaged and wastes accumulate in the body, it will cause great harm to the body. [0003] At present, there are 90 million kidney patients in my country, and among them, uremia patients are increasing at a rate of 5%-10% every year. According to data, since 200...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P13/12A61K131/00
Inventor 曾永篪李军金圣煊孙静芸
Owner 浙江金石亚药医药科技有限公司
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