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Isoflavone compound and prepration method and application thereof

A compound and isoflavone technology, which is applied in the field of tobacco additives, can solve the problem of undiscovered isoflavones, etc., and achieve the effects of high purity, sufficient supply of raw materials, and good free radical effect.

Inactive Publication Date: 2009-09-23
YUNNAN RES INST OF TOBACCO SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no related reports have been found for isoflavones

Method used

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  • Isoflavone compound and prepration method and application thereof
  • Isoflavone compound and prepration method and application thereof
  • Isoflavone compound and prepration method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The papaya extract used was provided by Yunnan Yuxi Wanfang Natural Products Co., Ltd. 500g of papaya extract was decolorized with MCI column, and eluted with pure acetone and 90% methanol, respectively. The acetone washed part was mainly chlorophyll and fatty acid. Collect 100g of the 90% methanol washed part, mix the sample with 200g of crude silica gel (80-100 mesh), pack 2.0 kg of silica gel (160-200 mesh) for silica gel column chromatography, chloroform:acetone (1:0→0:1) ) Gradient elution, TLC monitoring combined the same fractions to obtain 8 fractions (pure chloroform, chloroform-acetone 20:1, chloroform-acetone 9:1, chloroform-acetone 8: 2, chloroform-acetone 3: 2, chloroform- Acetone 1:1, chloroform-acetone 20:1, pure acetone), of which 11.8g of chloroform-acetone (1:1) elution fraction was separated by Agilent 1100 semi-preparative high performance liquid chromatography, using 35% methanol as the flow Phase, Zorbax SB-C 18 column (9.4×250mm, 5μm) semi-preparative...

Embodiment 2

[0028] The process of this embodiment is the same as that of embodiment 1, except that 85% methanol is used for elution and 30% methanol is used as the mobile phase.

Embodiment 3

[0030] The process of this embodiment is the same as that of embodiment 1, except that 95% methanol is used for elution and 40% methanol is used as the mobile phase.

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Abstract

The invention discloses an isoflavone compound with a novel structure, a preparation method and an application thereof. The compound has the structure as shown in the right formula; the invention uses an MCI column for bleaching a papaya liquid extract, uses the silica gel column chromatography for primary separation, and then adopts the semipreparative high-performance liquid chromatography for further separation, thereby obtaining the new compound which is named as 3',4',5'-trihydroxy-5, 7-dimethoxyisoflavone. An effect test of eliminating free radicals in mainstream cigarette smoke is carried out on the compound, and the test result shows that the compound has good effect of eliminating the free radicals.

Description

Technical field [0001] The present invention relates to a tobacco additive. More specifically, the present invention relates to a novel isoflavone compound. At the same time, the present invention also relates to the preparation method of the compound and its application in removing free radicals in mainstream cigarette smoke. Background technique [0002] Human beings have a history of 500 years since they discovered tobacco. As a special commodity, tobacco meets the physical and psychological needs of smoking consumers. However, with the advancement of society and the development of science and technology, relevant research data show that smoking has a certain impact on human health, and the contradiction between smoking and health has attracted increasing attention. [0003] Over the years, domestic and foreign tobacco companies have researched and applied various advanced production technology to gradually reduce harmful components in cigarette smoke and reduce the impact of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/36C07D311/40A24D3/14
Inventor 施红林范鹏徐祎然黄海涛李雪梅杨光宇
Owner YUNNAN RES INST OF TOBACCO SCI
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