Pharmaceutical composition containing enoximone and preparation method thereof

A technology of enoxinone and its composition, which is applied in the field of liquid pharmaceutical composition for injection containing enoxinone, can solve the problems of enoxinone hydrophobicity, etc., and achieve the effect of good reproducibility, simple process and high stability

Inactive Publication Date: 2009-10-07
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention prepares a liquid pharmaceutical composition of enoxinone for injection, which effectively solves the shortcomings of the existing enoxinone preparations, and at the same time solves the problem that enoxinone is extremely hydrophobic

Method used

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  • Pharmaceutical composition containing enoximone and preparation method thereof
  • Pharmaceutical composition containing enoximone and preparation method thereof
  • Pharmaceutical composition containing enoximone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023] Preparation:

[0024] Mix ethanol, propylene glycol and a certain amount of water for injection evenly, add sodium hydroxide solution, and adjust the pH value of the solution to 12.4; add enoxinone to the solution, dissolve, replenish the water for injection to the full amount, and adjust the pH value to 12.4; Semi-finished products are depyrogenated, coarsely filtered, finely filtered; filled, filled with nitrogen protection, sealed; sterilized, ready to use.

Embodiment 2

[0026]

[0027] Preparation:

[0028] Mix ethanol, PEG400 and a certain amount of water for injection evenly, add sodium hydroxide solution, and adjust the pH value of the solution to 12.4; add enoxinone to the solution, dissolve, replenish the water for injection to the full amount, and adjust the pH value to 12.4; Semi-finished products are depyrogenated, coarsely filtered, finely filtered; filled, filled with nitrogen protection, sealed; sterilized, ready to use.

Embodiment 3

[0030]

[0031] Preparation:

[0032] Mix ethanol, propylene glycol and a certain amount of water for injection evenly, add sodium sulfite to dissolve, and add sodium hydroxide solution to adjust the pH value of the solution to 12.4; add enoxinone to the solution, dissolve, replenish the water for injection to the full amount, and adjust pH value to 12.4; semi-finished product depyrogenation, coarse filtration, fine filtration; filling, filling with nitrogen protection, sealing; sterilization, ready to use.

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PUM

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Abstract

The invention discloses a liquid pharmaceutical composition containing enoximone and used for injection, and the liquid pharmaceutical composition also includes a solution stabilizer and a pH regulator accepted on pharmacology. The liquid pharmaceutical composition has good stability, is used for first aid treatment of the severe heart failure and is applied when the effects of other therapeutic methods are not satisfying.

Description

technical field [0001] The invention relates to a liquid pharmaceutical composition for injection used for emergency treatment of severe heart failure, in particular to a liquid pharmaceutical composition for injection containing enoxinone. Background technique [0002] Enoximone is a selective phosphodiesterase inhibitor used in the treatment of heart disease. This drug has positive inotropic effect, can enhance cardiac contractility, and also has vasodilator effect. It is suitable for emergency treatment of severe heart failure (cardiac insufficiency) (within 48 hours of onset), and it is applied when other treatment methods (such as cardiac glycosides, diuretics and / or vasodilators) are not satisfactory. This drug is also suitable for the treatment of acute cardiac insufficiency after surgery. [0003] Enoxinone is a very hydrophobic substance, and the focus of current formulations is mainly on solving its dissolution and release. EP0326103 discloses the use of Tween, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4166A61P9/04
Inventor 袁筝
Owner BEIJING D VENTUREPHARM TECH DEV
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