Extracting method of angelica ligustilide

A technique of ligustilide and an extraction method, which is applied in the field of extraction of ligustilide of Angelica sinensis, can solve the problems of unstable ligustilide monomer, easy to accelerate oxidative dehydrogenation of ligustilide, etc., and achieves reduction of excessive ligustilide. The effect of impurity components, the effect of improving yield, and expanding the scope of application

Inactive Publication Date: 2009-10-21
霸王(广州)有限公司
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the pharmacological activity reports of ligustilide are all carried out in the form of mixture, which is mainly because the monomer of ligustilide is unstable, and light and high temperature are easy to accelerate the oxidative dehydrogenation of ligustilide.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Extracting method of angelica ligustilide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the extraction method of a kind of angelica ligustilide of the present invention, its step is:

[0017] (1), using CO 2 Supercritical extraction of volatile oil of Angelica sinensis: Take the crude fraction of Angelica sinensis through a 40-mesh sieve, put it in an extraction kettle, and pass it through CO with a flow rate of 15L / h under an extraction environment with an analysis temperature of 25°C and an analysis pressure of 6Mpa. 2 , extracted for 1.5 hours to obtain the crude product of angelica volatile oil;

[0018] (2), the acquisition of the neutral oil part of Angelica sinensis: the above-mentioned crude volatile oil is extracted with 1% NaOH solution to obtain the neutral oil part of Angelica sinensis;

[0019] (3) Separation of ligustilide: dry the neutral oil over anhydrous sodium sulfate, put it on a silica gel column, and elute with a mixed solvent gradient of n-hexane: acetone, and use GC-MS as a detection method to collect ligustilide The...

Embodiment 2

[0021] Embodiment 2: the extraction method of a kind of angelica ligustilide of the present invention, its step is:

[0022] (1), using CO 2 Supercritical extraction of volatile oil of Angelica sinensis: Take the crude fraction of Angelica sinensis through a 40-mesh sieve, put it in an extraction kettle, and pass it through CO with a flow rate of 20L / h under an extraction environment with an analysis temperature of 35°C and an analysis pressure of 7.5Mpa. 2 , extracted for 2 hours to obtain the crude product of Angelica sinensis volatile oil;

[0023] (2), the acquisition of the neutral oil part of Angelica sinensis: the above-mentioned crude volatile oil is extracted with 1% NaOH solution to obtain the neutral oil part of Angelica sinensis;

[0024] (3) Separation of ligustilide: dry the neutral oil over anhydrous sodium sulfate, put it on a silica gel column, and elute with a mixed solvent gradient of n-hexane: acetone, and use GC-MS as a detection method to collect ligusti...

Embodiment 3

[0026] Embodiment 3: the extraction method of a kind of angelica ligustilide of the present invention, its step is:

[0027] (1), using CO 2 Supercritical extraction of volatile oil of Angelica sinensis: Take the crude fraction of Angelica sinensis through a 40-mesh sieve, place it in an extraction kettle, and pass it through CO with a flow rate of 25L / h under an extraction environment with an analysis temperature of 40°C and an analysis pressure of 8Mpa. 2 , extracted for 2.5 hours to obtain the crude product of angelica volatile oil;

[0028] (2), the acquisition of the neutral oil part of Angelica sinensis: the above-mentioned crude volatile oil is extracted with 1% NaOH solution to obtain the neutral oil part of Angelica sinensis;

[0029] (3) Separation of ligustilide: dry the neutral oil over anhydrous sodium sulfate, put it on a silica gel column, and elute with a mixed solvent gradient of n-hexane: acetone, and use GC-MS as a detection method to collect ligustilide T...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention relates to an extracting method of angelica ligustilide, which comprises the following steps: firstly, supercritical-extraction of angelica naphtha by using CO2: taking coarse angelica filtered by a 40mu sieve, placing the filtered coarse angelica into an extraction kettle to be extracted for 1.5-2.5h by leading CO2 with flow being 15-25L / h under the extraction environments of resolution temperature being 25-40 DEG C and resolution pressure being 6-8MPa so as to obtain coarse angelica naphtha; secondly, obtaining of angelica neutral oil: extracting the coarse angelica naphtha by using 1 percent NaOH solution to obtain the angelica neutral oil; thirdly, separation of ligustilide: drying the angelica neutral oil by using anhydrous sodium sulfate, applying a silica gel column, gradiently eluting by using the mixed solution of normal hexane and acetone, adopting GC-MS as a detection means, collecting eluent of the ligustilide, and evaporating solvent by using nitrogen flow. The invention has the advantages of simple and convenient operation, high extraction efficiency, better reliability, higher extraction purity, and the like.

Description

technical field [0001] The invention mainly relates to the technical field of extracting substances from natural plants, in particular to an extracting method of angelica ligustilide. Background technique [0002] With the progress of human social civilization and the rapid development of modern science and technology, human living conditions and living environment are constantly changing. Human health concepts and awareness of the pursuit of quality of life are enhanced, making the connotation of health continue to expand. In the international trend of human returning to nature, all countries in the world have realized the huge market potential of natural plants, and the international market of natural plants is expanding rapidly. According to the report of the World Bank, the world's natural medicine industry will reach 200 billion US dollars in 2008. [0003] Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels of Umbelliferae. Angelica has a medicinal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/88A61K36/232A61K31/365
CPCY02P20/54
Inventor 陈启源万玉华沈小笛万保春麻睿
Owner 霸王(广州)有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap