Production method of ribonucleotide sodium salt

A technology of nucleotide sodium and sodium salt, which is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc. It can solve the problems of low product yield, cumbersome operation, and high water content of sodium salt

Inactive Publication Date: 2009-10-21
SHANDONG KAISHENG NEW MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, it should also be pointed out that due to the large water content of sodium salts, some sodium salts cannot be crystallized well according to routine, such as disodium adenylate (AMPNa 2 ) is easy to become a viscous liquid, and som...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0007] Example 1: tetrasodium adenylate AMPNa 4 Preparation: Add 45ml of water to 15g of AMP, add 17ml of 30% liquid caustic soda, drop in 210ml of 95% ethanol, precipitate white crystals and filter for about 4 hours, wash and dry with 100ml of ethanol to obtain AMPNa 4 22.91g, water content 20%, weight yield 152.71%. 5% aqueous solution, pH value 12.32, chromatographic content 98.10%, UV content according to AMPNa85.12%, AMPNa 2 90.19%, AMPNa 3 95.26%, AMPNa 4 100.34%, judging from the content and strong pH value, it is not disodium 5'-adenylate but tetrasodium 5',2',3'-adenylate.

example 2

[0008] Example 2: Preparation of AMPNa: Add 60ml of water to adjust the pH value of 15 grams of AMP to dissolve, add 240ml of 95% ethanol to separate out AMPNa, filter, wash and dry, the content is 98.5%, and the pH value of 5% aqueous solution is 5.82.

example 3

[0009] Example 3: AMPNa 2 Preparation: Add 45ml of water to 15g of AMP to adjust the pH value to dissolve, add 210ml of 95% ethanol to precipitate AMPNa, then slowly add alkali to react to obtain AMPNa with good crystal form, no lumps, and no stickiness 2 , content 99.63%.

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PUM

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Abstract

As a food additive and a pharmaceutical intermediate, the ribonucleotide sodium salt is very important. The ribonucleotide comprises an adenylic acid, a cytidylic acid, a uridylic acid, a guanylic acid and an inosinic acid. The sodium salt is usually 5'-ribonucleotide disodium. The invention relates to and adopts a special preparation technology for resolving the problem of bad crystal form and can obtain a plurality of types of sodium salt even tetrasodium salt, and the invention has the characteristics of good crystal form, high quality and high yield.

Description

1. Technical field [0001] Nucleotides and their sodium salts are extremely important as food additives and pharmaceutical intermediates. The present invention relates to the use of a special preparation process to solve the difference in crystal form and improve the quality and yield of sodium salts. 2. Technical background [0002] In the prior art, nucleic acid degradation method, chemical synthesis and enzymatic synthesis are used to prepare nucleotides. In terms of molecular structure, nucleotides are generally composed of nucleosides and phosphoric acid, and nucleosides are composed of pentose sugars and bases. , where the phosphoric acid is connected to the fifth carbon of the sugar and is called 5'-nucleotide, and the phosphoric acid at the 5' position has two hydroxyl groups, which can react with a base to form a sodium salt, that is, 5'-nucleotide disodium. It is found that when it reacts with alkali, it can generate various sodium salts or even tetrasodium at diffe...

Claims

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Application Information

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IPC IPC(8): C07H19/20C07H19/10C07H1/00
Inventor 王荣海肖文凯郗新才毕义霞田恒强
Owner SHANDONG KAISHENG NEW MATERIALS
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