Traditional Chinese medicine injection for treating canine parvovirus disease and preparation method thereof

A technology of canine parvovirus and medicine, which is applied in the direction of antiviral agents, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of difficult prevention, failure to reach the treatment site, difficulties, etc., achieve no toxic side effects, avoid Nausea, high cure rate effect

Inactive Publication Date: 2009-10-28
MILITARY VETERINARY RES INST PLA MILITARY MEDICAL ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high variability of CPV, it has brought certain difficulties to its prevention, and the disease often occurs due to the low protection rate of the vaccine.
In addition, the current treatment of CPV often uses hyperimmune serum, ribavirin, penicillin, gentamicin, dexamethasone, hemostatic drugs, vitamin B, vitamin C and symptomatic therapy, the treatme

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh Pulsatilla 150kg, Daqingye 150kg, Honeysuckle 150kg, Rhubarb 30kg, Sophora japonica 120kg, Coptis 100kg, Astragalus 150kg, Black plum 150kg, Curcuma 100kg, Myrobalan 100kg, Agrimony 150kg, Ginger Pinellia 100kg, steam Pulsatilla, Curcuma Distillation, the distillate is subjected to secondary distillation to obtain Pulsatilla vulgaris, turmeric vapor liquid, and medicinal residues for later use; add 6 times 85% ethanol to reflux twice for Agrimony and Jiang Pinellia, 1 hour each time, combine the ethanol reflux liquid, and recover ethanol until it is free of alcohol Taste, get Agrimony, Ginger Pinellia Alcoholic Extract; Daqingye, honeysuckle, rhubarb, Sophora japonica, Coptis chinensis, Astragalus, ebony, myrobalan, Pulsatilla pulsatillae, turmeric dregs add 3 times the amount and boil twice, 1 hour each time, Concentrate to 1 / 10 of the original volume, add 65% volume of ethanol, stir, stand at 4°C for 24h, filter, recover ethanol from the filtrate until it has no ...

Embodiment 2

[0027] Weigh Pulsatilla 450kg, Daqingye 300kg, Honeysuckle 300kg, Rhubarb 50kg, Sophora japonica 200kg, Coptidis 200kg, Astragalus 100kg, Black plum 250kg, Curcuma 150kg, Myrobalan 300kg, Agrimony 300kg, Ginger Pinellia 200kg, steam Pulsatilla, Curcuma Distillation, the distillate is subjected to secondary distillation to obtain Pulsatilla vulgaris, turmeric vapor liquid, and medicinal residues for later use; Agrimony and Jiang Pinellia add 8 times 75% ethanol to reflux 3 times, each time for 1 hour, combine the ethanol reflux liquid, and recover the ethanol until it is free of alcohol Taste, get Agrimony, Ginger Pinellia Alcoholic Extract; Daqingye, honeysuckle, rhubarb, Sophora japonica, Coptis chinensis, Astragalus, ebony, Myrobalan and Pulsatilla pulsatillae, turmeric dregs add 3 times the amount and boil twice, 1 hour each time, Concentrate to 1 / 10 of the original volume, add 65% volume of ethanol, stir, stand at 4°C for 24h, filter, recover ethanol from the filtrate until...

Embodiment 3

[0029]Weigh Pulsatilla 500kg, Folium Folium 200kg, Honeysuckle 400kg, Rhubarb 100kg, Sophora japonica 150kg, Coptidis 100kg, Astragalus 200kg, Ume 300kg, Curcuma 200kg, Myrobalan 250kg, Agrimony 150kg, Ginger pinellia 100kg, steam Pulsatilla, Curcuma Distillation, the distillate is subjected to secondary distillation to obtain Pulsatilla vulgaris and Curcuma vapor liquid, and the medicinal residues for later use; Agrimony and Jiang Pinellia add 10 times 65% ethanol to reflux for 3 times, each time for 1 hour, combine the ethanol reflux liquid, and recover the ethanol until it is free of alcohol Taste, get Agrimony, Ginger Pinellia Alcoholic Extract; Daqingye, honeysuckle, rhubarb, Sophora japonica, Coptis chinensis, Astragalus, ebony, Myrobalan and Pulsatilla pulsatillae, turmeric dregs add 3 times the amount and boil twice, 1 hour each time, Concentrate to 1 / 10 of the original volume, add 65% volume of ethanol, stir, stand at 4°C for 24h, filter, recover ethanol from the filtr...

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Abstract

The invention relates to a traditional Chinese medicine injection for treating canine parvovirus disease, wherein crude drugs of the injection consist of following components: 100 parts by weight (pbw) to 500pbw of Chinese pulsatilla root, 100pbw to 300pbw of indigowoad leaves, 100pbw to 400pbw of honeysuckle flowers, 10pbw to 100pbw of rhubarb, 100pbw to 200pbw of flos sophorae, 100pbw to 200pbw of rhizoma coptidis, 100pbw to 300pbw of radix astragali, 100pbw to 300pbw of dark plum fruits, 100pbw to 200pbw of radix curcumae, 100pbw to 300pbw of myrobalam, 100pbw to 300pbw of hairyvein agrimonia herb and bud and 100pbw to 200pbw of rhizoma pinelliae processed with gingers; the invention also discloses a preparation method of the injection, which comprises the steps of: conducting steam distillation extraction on the Chinese pulsatilla root and the radix curcumae, conducting alcohol extraction on the hairyvein agrimonia herb and the rhizoma pinelliae, and conducting water-alcohol extraction on the indigowoad leaves, the honeysuckle flowers, the rhubarb, the flos sophorae, the rhizoma coptidis, the radix astragali, the dark plum fruits and the myrobalam, thereby obtaining the injection. The injection can achieve the purpose of treating the canine parvovirus disease by clearing away heat and toxic material, dispelling heat and relaxing bowels, relieving diarrhea with astringents, cooling blood to stop blood, calming the adverse-rising energy and arresting vomiting. The injection is the traditional Chinese medicine injection prepared by extracting and refining traditional Chinese medicinal materials, thus having no toxicity or side effect on the canine, with quick effect and high cure rate after injection.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection for treating canine parvovirus disease and a preparation method thereof, specifically an injection prepared by taking Chinese herbal medicine as a raw material, and belongs to the technical field of traditional Chinese medicine. Background technique: [0002] Canine parvovirus (CPV) is a member of the genus Parvovirus, a single-stranded small DNA virus, closely related to feline parvovirus (FPV) and mink enteritis virus (MEV). In 1978, for the first time, CPV was isolated from sick dogs suffering from enteritis. The sick dogs were mainly characterized by vomiting, hemorrhagic enteritis, and leukopenia. The puppies were highly susceptible and could cause myocarditis in puppies; (MCV) was named CPV-2, which was subsequently discovered in canines in many countries and regions, with a morbidity rate of 50% to 100% and a mortality rate of 0% to 50%. Economic animal farming is very harmful, ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/08A61P31/20
Inventor 李乾学
Owner MILITARY VETERINARY RES INST PLA MILITARY MEDICAL ACAD OF SCI
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