Iron metabolism-improving agent

An iron metabolism and improving agent technology, applied in metabolic diseases, blood diseases, extracellular fluid diseases, etc., can solve the problems of dependence and the improvement of abnormal iron metabolism without disclosure, achieve improved prognosis, avoid the risk of complications, The effect of preventing hypercytokineemia

Inactive Publication Date: 2009-10-28
AJINOMOTO CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] However, the current situation is that there is no specific method for improving abnormal iron metabolism in patients with chronic renal failure who have received blood purification therapy, that is, improving the inhibition of excess iron uptake and release into cells, or for transferring iron in the reticuloendothelial system. The solution of the iron accumulated in the blood to be utilized in the hematopoietic system
In addition, the current situation is that as a treatment method for chronic renal failure patients with EPO-resistant anemia, adjuvant therapy using EPO preparation therapy taking iron is effective, but there is no special method except relying on the experience of professional physicians

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1: For dogs with renal failure, the effect of dialysis preparations on iron metabolism

[0077] Using dogs with renal failure, dialysis was actually performed to study the effect on iron metabolism at this time.

[0078] [experiment method]

[0079] For male beagle dogs on a fast for about 18 hours, the pentobarbital sodium (30mg / kg) was administered intravenously through the radial skin for anesthesia, and then the abdominal section was cut from the midline, and the urinary tubes on both sides were completely ligated.

[0080] Dialysis experiments were performed on the second day after the operation. As an introductory anesthesia, sodium pentobarbital (30 mg / kg) is administered intravenously from the radial skin. In order to maintain anesthesia even during dialysis, pentobarbital sodium can be continuously administered intravenously using an infusion pump.

[0081] An 8Fr catheter filled with heparin-added physiological saline (10 units / mL) was inserted and fixed...

Embodiment 2

[0105] Example 2: Improvement of iron metabolism by administering citric acid to rats with both kidneys removed Good effect research

[0106] Rats with all the kidneys removed were used to study the effect of iron metabolism when citric acid was administered.

[0107] [experiment method]

[0108] Using 8-week-old male CD (SD) rats (body weight about 300 g), the test was performed using the test group in Table 3 below. After the rats were anesthetized by intraperitoneal administration of sodium pentobarbital (50 mg / kg), all the kidneys were removed from the back and middle of the rats (the first group in Table 3 was not treated), and the central venous catheter (CVC) indwelling operation was performed .

[0109] About 24 hours after the operation was performed, 1 mL of blood was collected by CVC. For the second and third groups in Table 3, immediately after that, physiological saline or 4.5w / v% sodium citrate solution was added to each of 0.25 mL by CVC. The administration rate...

Embodiment 3

[0118] Example 3: Produced by administering citric acid during dialysis to rats with both kidneys removed Study on the effect of improving iron metabolism

[0119] Rats on the second day after all the kidneys were removed to study the effect on iron metabolism when citric acid was administered during dialysis.

[0120] [experiment method]

[0121] Using male CD (SD) rats, the test was performed by the test group in Table 4 below. After the rats were anesthetized by intraperitoneal administration of sodium pentobarbital (50 mg / kg), all the kidneys were removed from the back and middle of the rats.

[0122] Two days after the operation, the rats were anesthetized by intraperitoneal administration of sodium pentobarbital (50 mg / kg), and catheters were placed in the left thigh artery and left thigh vein to make blood inlets and outlets. At the same time, it was used for citric acid administration and blood collection. Perform central venous catheter (CVC) indwelling surgery. After...

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PUM

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Abstract

Disclosed is an iron metabolism-improving agent for improving the iron metabolism in the body of a patient having chronic renal failure who is receiving a blood purification therapy such as hemodialysis, hemofiltration and hemodialysis filtration. The iron metabolism-improving agent does not contain acetic acid and/or an acetic acid salt as an electrolyte, comprises citric acid and/or a citric acid salt, and further comprises other electrolyte(s) and glucose alone or in combination. The iron metabolism-improving agent is in the form of a dialysis fluid and/or a substitution fluid for dialysis. Also disclosed is a method for improving the iron metabolism in a living body by using the dialysis fluid and/or the substitution fluid for dialysis. Further disclosed is a blood purification method including hemodialysis and hemodialysis filtration for a patient having chronic renal failure.

Description

Technical field [0001] The present invention relates to an iron metabolism improving agent for improving iron metabolism in a living body, and particularly relates to an iron metabolism improving agent for improving iron metabolism in the body of patients with chronic renal failure who have received blood purification treatments such as hemodialysis, hemofiltration, and hemofiltration dialysis. [0002] Furthermore, the present invention relates to a method for improving iron metabolism in the body by administering the iron metabolism improving agent to patients with chronic renal failure undergoing blood purification treatments such as hemodialysis, hemofiltration, and hemofiltration A method for improving the iron metabolism in the living body by using a dialysate and / or a replenisher for dialysis. [0003] Furthermore, the present invention relates to a blood purification method, which includes hemodialysis and hemofiltration dialysis for blood purification in patients with chr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61P3/02A61P7/06A61P7/08A61P13/12A61P43/00
Inventor 中西健仓贺野隆裕赤池信英中西敬
Owner AJINOMOTO CO INC
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