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Migltol microcapsule tablet and preparation method thereof

A kind of technology of miglitol, microcapsule tablet

Active Publication Date: 2011-02-23
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In view of the miglitol wet-processed granules in the prior art, which are easy to coke at about 70-80°C, the tablets produced by common methods such as direct compression, wet granulation and dry granulation The agent is easy to absorb moisture during storage, which affects the stability of the drug, and there are problems such as content decrease, dissolution rate decrease and related substances increase. This requires a new method to improve the quality of miglitol tablets and prepare a quick-acting product. , Miglitol tablets with high safety to meet clinical needs

Method used

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  • Migltol microcapsule tablet and preparation method thereof
  • Migltol microcapsule tablet and preparation method thereof
  • Migltol microcapsule tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Microcapsule preparation of miglitol of the present invention

[0035] Name of raw and auxiliary materials Dosage / g

[0036] Miglitol 50

[0037] Starch 10

[0038] Type IV acrylic resin 30

[0039] MCC 50

[0040] CMS-Na 3

[0041] 70% ethanol aqueous solution

[0042] 1000 pieces in total

[0043] Preparation Process:

[0044] ① Pass the prescribed amount of Miglitol through a 60-120 mesh sieve, place it in a fluidized bed, and pass hot air into it to make it suspend and fluidize. The temperature of the hot air is 45-55°C;

[0045] ②Dissolve starch and type IV acrylic resin with an appropriate amount of 70% ethanol aqueous solution to make a 15% capsule material solution. The capsule material solution is atomized and continuously fed into the fluidized bed through the nozzle of the fluidized bed, where the atomization pressure is 0.25~0.30Mpa , The spraying speed is 50-60 rpm, and the air is continuously fed for drying. After the solution is sprayed, the heating is stopped, and the ...

Embodiment 2

[0048] Microcapsule preparation of miglitol of the present invention

[0049] Name of raw and auxiliary materials Dosage / g

[0050] Miglitol 50

[0051] Polyethylene glycol 15

[0052] HPMC 20

[0053] Lactose 60

[0054] CMC-Na 4

[0055] 70% ethanol aqueous solution

[0056] 1000 pieces in total

[0057] Preparation Process:

[0058] ① Pass the prescribed amount of Miglitol through a 60-120 mesh sieve, place it in a fluidized bed, and pass hot air into it to make it suspend and fluidize. The temperature of the hot air is 45-55°C;

[0059] ②Dissolve HPMC and polyethylene glycol with an appropriate amount of 70% ethanol aqueous solution to make a 15% capsule material solution. The capsule material solution is atomized and continuously fed into the fluidized bed through the nozzle of the fluidized bed, where the atomization pressure is 0.25~0.30Mpa , The spraying speed is 50-60 rpm, and the air is continuously fed for drying. After the solution is sprayed, the heating is stopped, the material...

Embodiment 3

[0062] Microcapsule preparation of miglitol of the present invention

[0063] Name of raw and auxiliary materials Dosage / g

[0064] Miglitol 50

[0065] PVP 35

[0066] Calcium hydrogen phosphate 20

[0067] MCC 40

[0068] Copovidone S-630 4

[0069] 70% ethanol aqueous solution

[0070] 1000 pieces in total

[0071] Preparation Process:

[0072] ① Pass the prescribed amount of Miglitol through a 60-120 mesh sieve, place it in a fluidized bed, and pass hot air into it to make it suspend and fluidize. The temperature of the hot air is 45-55°C;

[0073] ②Dissolve PVP with an appropriate amount of 70% ethanol aqueous solution to make a 20% capsule material solution. The capsule material solution is atomized and continuously fed into the fluidized bed through the nozzle of the fluidized bed. The atomization pressure is 0.25~0.30Mpa, and the spraying speed is 50-60 rpm, continuous air drying, stop heating after the solution is sprayed, cool and discharge, obtain miglitol microcapsules for use;

...

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Abstract

The invention relates to a migltol microcapsule tablet and preparation method thereof. Migltol is put in a fluidized bed; then capsule solution is continuously added to the fluidized bed after atomized by the nozzle of the fluidized bed, and migltol microcapsules are produced; the migltol microcapsule, disintegrating agent and thinner of the unit formula are uniformly mixed, and the mixture is tabletted according to routine techniques to produce the migltol microcapsule tablet. The preparation method of the invention can remarkably increase the stability of migltol, thus being more suitable for commercial process. The migltol microcapsule tablet of the invention can be steadily and rapidly released in bodies to perform the diabetes-treating function of migltol.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a diabetic medicine miglitol microcapsule tablet and a preparation method thereof. technical background [0002] Diabetes is a common disease that endangers human health. The number of diabetic patients worldwide is increasing at an alarming rate. The 2003 epidemiological survey showed that there were nearly 200 million diabetic patients worldwide, and it is estimated that this number will exceed 300 million by 2025. . With the rapid development of my country's economy, patients with diabetes are also showing a trend of rapid growth. In the past 20 years, the prevalence of diabetes in my country has increased from less than 1% to 3.21%. Based on the current growth trend, it is estimated that by 2025, China's diabetic patients will exceed 50 million. At present, China has become the world's second largest country with diabetes after India. Diabetes complications are serious. In ou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/445A61K47/42A61P3/10A61K47/10A61K47/32A61K47/36A61K47/38
Inventor 赵志全王玉广
Owner LUNAN PHARMA GROUP CORPORATION
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