Reboxetine mesylate microencapsule tablet and preparation method thereof

A technology of reboxetine mesylate and microcapsules, which is applied in the field of reboxetine microcapsules and its preparation, can solve the problems of increasing adverse drug reactions, increasing blood drug concentration, adverse reactions, etc., and achieve improved bioavailability , enhance the therapeutic effect, reduce the effect of side effects

Active Publication Date: 2013-04-24
NANJING ZENKOM PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] 4. Adverse reactions
However, for patients with depression, they need to take medicine three times a day, and the compliance is poor. At the same time, after taking medicine for many times, the fluctuation of blood drug concentration in the body is increased, the adverse reaction of the medicine is increased, and the healing time of the disease is delayed. Therefore, Ripple Mesylate was developed. Sustained-release formulations of cetine are imminent

Method used

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  • Reboxetine mesylate microencapsule tablet and preparation method thereof
  • Reboxetine mesylate microencapsule tablet and preparation method thereof
  • Reboxetine mesylate microencapsule tablet and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0034] prescription:

[0035]

[0036]Pass the prescribed amount of reboxetine mesylate through a 80-mesh sieve, put it in a fluidized bed, feed hot air, the temperature of the hot air is 45°C, add the prescribed amount of talcum powder; mix gum arabic and dimethyl methacrylate Aminoethyl ester is made into 15% capsule material solution with an appropriate amount of 70% ethanol aqueous solution for subsequent use, and the capsule material solution is atomized by a fluidized bed nozzle, sprayed and attached to the surface of the micropowder, the spray atomization pressure is 0.35Mpa, and the spray speed is 45rpm, continuous ventilating and drying, after coating finishes, stop heating, cool to 30 ℃, discharge, obtain reboxetine mesylate microcapsules; Mix the prepared reboxetine mesylate microcapsules with the microcrystalline Cellulose, lactose, sodium carboxymethyl starch, and magnesium stearate are mixed evenly, and directly compressed into tablets.

Embodiment 2

[0038] prescription:

[0039]

[0040] Pass the prescribed amount of reboxetine mesylate through a 80-mesh sieve, place it in a fluidized bed, feed hot air, the temperature of the hot air is 45°C, add the prescribed amount of magnesium stearate; mix polyvinyl alcohol and hypromellose The base cellulose is made into 12% capsule material solution with an appropriate amount of 70% ethanol aqueous solution for subsequent use. The capsule material solution is atomized through a fluidized bed nozzle and sprayed on the surface of the micropowder. The spray atomization pressure is 0.40Mpa, and the spray speed is 45rpm, continuous ventilating and drying, after coating finishes, stop heating, cool to 30 ℃, discharge, obtain reboxetine mesylate microcapsules; Mix the prepared reboxetine mesylate microcapsules with the prescribed amount of hydrogen phosphate Calcium, starch, sodium starch glycolate, and magnesium stearate are mixed evenly, and directly compressed into tablets.

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Abstract

The invention discloses a reboxetine mesylate microencapsule tablet and a preparation method thereof. According to the reboxetine mesylate microencapsule tablet provided by the invention, reboxetine overcomes the defects of blood concentration peak and valley happening after common tablets and capsules are taken, the release of main drug reboxetine is retarded, and the medicinal stability is improved. The reboxetine mesylate microencapsule tablet is prepared by producing microencapsules by adopting a fluidized bed coating method and tabletting, and consists of the following components in percentage by weight: 10 to 50 percent of reboxetine mesylate, 1 to 5 percent of lubricant, 10 to 40 percent of capsule material, and 5 to 80 percent of other auxiliary disintegrant and diluting agent.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, and relates to a new dosage form of reboxetine, in particular to a microcapsule tablet of reboxetine and a preparation method thereof. Background technique [0002] In today's society, with the increasingly tense pace of life and various pressures, the number of patients with depression is astonishing. The pathogenesis of depression is mainly due to the low content of central norepinephrine (NE), 5-hydroxytryptamine (5-HT) and dopamine (DA) in the body and the decline of their receptor function. The functions of monoamine neurotransmitters in the brain are relatively complex, among which 5-HT seems to play a basic role in controlling sensory responses, NE is mainly related to insomnia and inattention, and DA controls more running and cognitive functions. These neurotransmitters have complex interactions, and together affect the human body's psychological behaviors such as anxiety and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61K31/5375A61P25/24A61P25/22A61J3/00
Inventor 徐卓业汪磊文意芬
Owner NANJING ZENKOM PHARMA
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