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Reboxetine mesylate microencapsule tablet and preparation method thereof

A technology of reboxetine mesylate and microcapsules, which is applied in the field of reboxetine microcapsules and its preparation, can solve the problems of increasing adverse drug reactions, increasing blood drug concentration, adverse reactions, etc., and achieve improved bioavailability , enhance the therapeutic effect, reduce the effect of side effects

Active Publication Date: 2012-01-18
NANJING ZENKOM PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] 4. Adverse reactions
However, for patients with depression, they need to take medicine three times a day, and the compliance is poor. At the same time, after taking medicine for many times, the fluctuation of blood drug concentration in the body is increased, the adverse reaction of the medicine is increased, and the healing time of the disease is delayed. Therefore, Ripple Mesylate was developed. Sustained-release formulations of cetine are imminent

Method used

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  • Reboxetine mesylate microencapsule tablet and preparation method thereof
  • Reboxetine mesylate microencapsule tablet and preparation method thereof
  • Reboxetine mesylate microencapsule tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription:

[0035]

[0036] Pass the prescription amount of reboxetine mesylate through an 80 mesh sieve, place it in a fluidized bed, and pass in hot air at a temperature of 45°C. Add prescription amount of talc; combine gum arabic and dimethyl methacrylate The amino ethyl ester is made into a 15% capsule material solution with an appropriate amount of 70% ethanol aqueous solution for later use. The capsule material solution is atomized through a fluidized bed nozzle and sprayed on the surface of the fine powder. The spray atomization pressure is 0.35Mpa and the spray speed is 45rpm, continuous ventilation and drying, after coating, stop heating, cool to 30°C, discharge, and obtain reboxetine mesylate microcapsules; combine the prepared reboxetine mesylate microcapsules with the prescribed amount of microcrystals Cellulose, lactose, sodium starch glycolate, and magnesium stearate are mixed uniformly and directly compressed to obtain a tablet.

Embodiment 2

[0038] prescription:

[0039]

[0040] Pass the prescription amount of Reboxetine mesylate through an 80-mesh sieve, place it in a fluidized bed, pass in hot air at a temperature of 45°C, and add a prescription amount of magnesium stearate; combine the polyvinyl alcohol and hypromellose The base cellulose is made into a 12% capsule material solution with an appropriate amount of 70% ethanol aqueous solution for use. The capsule material solution is atomized through a fluidized bed nozzle and sprayed on the surface of the fine powder. The spray atomization pressure is 0.40Mpa, and the spray speed is 45rpm, continuous ventilation and drying, after the coating is finished, stop heating, cool to 30℃, discharge, and obtain reboxetine mesylate microcapsules; combine the prepared reboxetine mesylate microcapsules with the prescription amount of hydrogen phosphate Calcium, starch, sodium starch glycolate, and magnesium stearate are mixed uniformly and directly compressed to obtain a tabl...

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Abstract

The invention discloses a reboxetine mesylate microencapsule tablet and a preparation method thereof. According to the reboxetine mesylate microencapsule tablet provided by the invention, reboxetine overcomes the defects of blood concentration peak and valley happening after common tablets and capsules are taken, the release of main drug reboxetine is retarded, and the medicinal stability is improved. The reboxetine mesylate microencapsule tablet is prepared by producing microencapsules by adopting a fluidized bed coating method and tabletting, and consists of the following components in percentage by weight: 10 to 50 percent of reboxetine mesylate, 1 to 5 percent of lubricant, 10 to 40 percent of capsule material, and 5 to 80 percent of other auxiliary disintegrant and diluting agent.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, relates to a new dosage form of reboxetine, and specifically relates to a reboxetine microcapsule tablet and a preparation method thereof. Background technique [0002] In today's society, with the increasingly tense pace of life and various pressures, the number of patients with depression is staggering. The main cause of depression is the low levels of central norepinephrine (NE), serotonin (5-HT) and dopamine (DA) in the body and decreased receptor function. The functions of monoamine neurotransmitters in the brain are more complicated. Among them, 5-HT seems to play a basic role in controlling sensory responses, NE is mainly related to insomnia and lack of concentration, and DA controls more operation and cognitive functions. These neurotransmitters have complex interactions, which together affect the body's psychological behaviors such as anxiety and tension. [0003] Reboxetine mesyla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K31/5375A61P25/24A61P25/22A61J3/00
Inventor 徐卓业汪磊文意芬
Owner NANJING ZENKOM PHARMA
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