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Microarray reader based on evanescent wave detection and method of reading a microarray

A microarray and reader technology, applied in biochemical equipment and methods, instruments, measuring devices, etc., can solve the needs of real-time PCR microarray detection, the reader is not suitable for one-time chip application, high Cost and other issues

Active Publication Date: 2009-11-25
HONEYWELL INT INC
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Problems solved by technology

However, these readers are not suitable for single-use chip applications because of the high cost of waveguide fabrication and stringent alignment and coupling requirements
Because of the unique requirements for temperature control and sampling synchronization, none of the existing microarray readers can meet the needs of real-time PCR microarray detection

Method used

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  • Microarray reader based on evanescent wave detection and method of reading a microarray
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  • Microarray reader based on evanescent wave detection and method of reading a microarray

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Embodiment Construction

[0012] The following detailed description includes references to the accompanying drawings, which form a part hereof. The drawings show by way of illustration specific embodiments in which the invention may be practiced. These embodiments, also referred to herein as "examples," are described in sufficient detail to enable those skilled in the art to practice the invention. The described embodiments may be combined, other embodiments may be utilized, or structural and logical changes may be made without departing from the scope of the present invention. Therefore, the following detailed description should not be read in a limiting sense, and the scope of the invention should be defined by the appended claims and their equivalents.

[0013] As used herein, the term "a" is used to include one or more than one, and the term "or" is used to mean a non-exclusive "or" unless stated otherwise. Also, it should be understood that the phraseology or terminology used herein and not othe...

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Abstract

A microarray reader (100) comprises a light source (102), beam shaping elements (104) positioned near the light source (102), a moving stage (124) supporting one or more of the light source (102) and beam shaping elements (104), an optical substrate (112) supporting an immobilized microarray, a reaction chamber (116) in contact with the optical substrate (112) and encapsulating buffer solution, a heating / cooling component (118) in contact with the reaction chamber (116), a synchronization circuit, an optical filter (108) and an imaging sensor (106) positioned near the optical filter (108).

Description

technical field [0001] Embodiments of the invention relate to microarray readers based on evanescent wave detection. In particular, embodiments of the invention relate to microarray readers for real-time PCR microarrays based on evanescent wave detection. Background technique [0002] Traditionally used microarray readers are based on fluorescent labels, confocal microscopy and evanescent fields. Examples include fluorescence scanning confocal microscopy and total internal reflection (TIR) ​​fluorescence microscopy. These readers have a small field of view and require precise moving parts to scan the array, which results in costly and slow reads. One method involves exciting the entire probe array by extending a light source with a uniform intensity distribution. However, due to the lower excitation, lower sensitivity results. [0003] Microarray readers with waveguide structures can yield high sensitivity and have no moving parts. However, these readers are not suitabl...

Claims

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Application Information

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IPC IPC(8): G01N21/64C12Q1/68G01N33/53
CPCG01N21/648G01N21/6452
Inventor 郑媛徐亮孙震宏
Owner HONEYWELL INT INC
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