Unlock instant, AI-driven research and patent intelligence for your innovation.

Compound erythromycin zinc acetate ointment for local use

A technology of compound erythromycin and zinc acetate, which is applied in the field of medicine to achieve the effects of convenient use, good therapeutic effect and low price

Inactive Publication Date: 2009-12-02
NANJING CHANGAO PHARMA SCI & TECH CO LTD
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the defects of existing solutions in clinical use, the invention provides a kind of ointment which is easy to use, has good medication compliance and little skin irritation; With the problem of present use, a kind of stable erythromycin zinc acetate ointment and preparation method thereof are provided

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound erythromycin zinc acetate ointment for local use
  • Compound erythromycin zinc acetate ointment for local use
  • Compound erythromycin zinc acetate ointment for local use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Erythromycin 40g

[0028] Zinc acetate 12g

[0029] PEG600733.3g

[0030] Triethanolamine 30.3g

[0031] Add ethanol to 1000g

[0032] Preparation Process:

[0033] (1) Add erythromycin, zinc acetate, and sodium stearate to ethanol, stir to dissolve, and filter.

[0034] (2) Heat PEG6000 and PEG600 to 70-80°C to melt and stir well;

[0035] (3) Add (1) into (2), stir while adding, emulsify in the same direction, mix evenly, and cool naturally.

Embodiment 2

[0037] Erythromycin 40g

[0038] Zinc acetate 12g

[0039] PEG600066.7g

[0040] PEG600733.3g

[0041] Triethanolamine 33.3g

[0042] Add ethanol to 1000g

[0043] Preparation Process:

[0044] (1) Add erythromycin, zinc acetate, and sodium stearate to ethanol, stir to dissolve, and filter.

[0045](2) Heat PEG6000 and PEG600 to 70-80°C to melt and stir well;

[0046] (3) Add (1) into (2), stir while adding, emulsify in the same direction, mix evenly, and cool naturally.

Embodiment 3

[0048] Erythromycin 30g

[0049] Zinc acetate 10g

[0050] PEG400 250g

[0051] PEG6000 258g

[0052] Octadecanol 20

[0053] Triethanolamine 25g

[0054] 95% ethanol 180g

[0055] tertiary butanol 180g

[0056] Preparation Process:

[0057] (1) Add erythromycin, zinc acetate and triethanolamine into a mixed solvent of ethanol and tert-butanol, stir to dissolve, and filter.

[0058] (2) Heat PEG6000 and PEG400 to 70-80°C to melt, and stir well;

[0059] (3) Add (1) into (2), stir while adding, emulsify in the same direction, mix evenly, and cool naturally.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicaments, and in particular relates to a compound erythromycin zinc acetate ointment for local use. The compound erythromycin zinc acetate ointment takes erythromycin and zinc acetate as active components and is clinically used for treating acne vulgaris. The ointment comprises the following components by weight: 1 to 6 percent of the erythromycin, 0.5 to 2.5 percent of the zinc acetate, 50 to 82.5 percent of ointment substrate, 2 to 5 percent of emulsifying agent, and ethanol; and the sum of the weight percentage of the components is 100 percent. The ointment has low occurring rate of adverse reaction of local skin, convenience for using and carrying, simple production process, stable product quality and suitability for industrialized production.

Description

Technical field: [0001] The invention belongs to the field of medicine, and relates to a stable compound erythromycin zinc acetate ointment and a preparation method thereof. Background technique: [0002] Acne is a chronic pilosebaceous gland inflammatory skin disease. The cause of the disease is related to the strong secretion of sebaceous glands, the increase of free fatty acids on the skin surface, and the infection of Propionibacterium acnes. Acne is a multifactorial pilosebaceous disease, including hypersecretion of sebum, hyperkeratosis of follicles, proliferation of Propionibacterium acnes, and excessive immune response. In addition, it is also related to genetic and psychological factors. During treatment, the choice of regimen should be aimed at the pathogenic link as much as possible. Its clinical manifestations are mainly acne, papules, pustules, nodules and cysts on the face, and individual patients may form sunken or hypertrophic scars, which seriously affect ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/30A61K9/06A61K47/34A61P17/10A61K31/7048A61K47/10
Inventor 谢晓燕张自强包玉胜何红燕吴小涛朱丽君黄海燕李战
Owner NANJING CHANGAO PHARMA SCI & TECH CO LTD