Application of penehyclidine hydrochloride oral cavity partial drug administration as dental surgery medicine

A technology of penehyclidine hydrochloride and topical administration, which is applied in the application field of dental surgery drugs, and can solve problems such as patient distress and inconvenient treatment

Inactive Publication Date: 2009-12-16
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Dental surgery usually stimulates the glands of the oral cavity and respiratory tract to secrete a large amount of saliva. Clinically, it is necessary to use a straw to suck out intermittently or allow the patient to spit out the large amount of saliva. This clinical physiological reaction brings inconvenience to the treatment on the one hand. It also causes great distress to patients

Method used

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  • Application of penehyclidine hydrochloride oral cavity partial drug administration as dental surgery medicine
  • Application of penehyclidine hydrochloride oral cavity partial drug administration as dental surgery medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1 Pharmacodynamics test

[0008] 1. Test material

[0009] 1.1 Test drug: Penehyclidine hydrochloride, prepared into 8 μg / ml, 16 μg / ml, 32 μg / ml colorless transparent liquid with sterile water for injection, batch number: 090601, provided by Chengdu Lisite Pharmaceutical Co., Ltd.

[0010] 1.2 Positive control drug: penehyclidine hydrochloride injection, specification: 1ml: 1mg, batch number: 081101, prepared into a 16 μg / ml solution with sterile water for injection, provided by Chengdu Lisite Pharmaceutical Co., Ltd.

[0011] 1.3 Main reagents: phenol red, sodium bicarbonate, and normal saline are commercially available.

[0012] 1.4 Experimental animals Class ICR mice, weighing 18-22 g, half male and half male, were provided by Jiancheng Bill Animal Farm in Jianyang City.

[0013] 1.5 Main instruments Electronic balance, BASIC semi-automatic biochemical analyzer.

[0014] 1.6 Experimental environment The room temperature is 18-24°C and the humidity is 40...

Embodiment 2

[0028] Embodiment 2 Adopt the spray preparation method of oral cavity topical administration mode

[0029] Take an appropriate amount of penehyclidine hydrochloride, add appropriate amount of water to make a solution containing 0.01-10 mg per 1 ml, and put it into a bottle with a spray device.

[0030] A Take 4g of penehyclidine hydrochloride, add 1000ml of water and stir to dissolve, add 1.5g of sodium benzoate, stir and dissolve, then divide into spray bottles, 1ml per bottle.

[0031] B. Add 2 g of penehyclidine hydrochloride, add 1000 ml of water and stir to dissolve, add 1.5 g of sodium benzoate, stir and dissolve, then divide into spray bottles, 1 ml per bottle.

Embodiment 3

[0032] Embodiment 3 Adopt the solution preparation method of local oral administration mode

[0033] Take an appropriate amount of penehyclidine hydrochloride, add appropriate amount of water to make a solution containing 0.01-10 mg per 1 ml, put it into a plastic bottle or a glass bottle, and obtain the product.

[0034] A: Take 1 g of penehyclidine hydrochloride, add 1000 ml of water and stir to dissolve, stir and mix well to dissolve, then pack into vials, 1 ml per bottle, sterilize at 121°C for 10 minutes, and then pack.

[0035] B: Take 2 g of penehyclidine hydrochloride, add 1000 ml of water and stir to dissolve, stir and mix well to dissolve, then dispense into vials, 1 ml per bottle, sterilize at 121°C for 10 minutes, and dispense to obtain the product.

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Abstract

The invention provides a new medical application of penehyclidine hydrochloride, mainly relating to the application of penehyclidine hydrochloride oral cavity partial drug administration as dental surgery medicine; the drug administration method adopted in the dental surgery is oral cavity partial drug administration, which can be either oral cavity spray method or oral cavity smear method. Penehyclidine hydrochloride can be prepared into pressurized sprays or can also be prepared into solutions.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the new medical application of penehyclidine hydrochloride, in particular to the application of penehyclidine hydrochloride in dental surgery drugs by oral cavity local administration. Background technique [0002] Penehyclidine hydrochloride, English name Penehyclidine Hydrochloride, chemical name 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)quinuclidine hydrochloride, molecular formula C 20 h 29 NO 2 • HCl, molecular weight 351.92. Penehyclidine hydrochloride is a new type of anticholinergic drug with selective M 1 , M 3 and N 1 , N 2 Receptor antagonism, has a strong anticholinergic effect on the central and peripheral, and has a strong anticholinergic effect on M 2 The receptor has no obvious effect, which can effectively avoid the tachycardia caused by atropine lack of M receptor subtype selectivity and block the presynaptic membrane M 2 Receptor regulation function...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P5/00A61P1/02
Inventor 黄绍渊张浩张玲
Owner CHENGDU LIST PHARMA
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