Method for synthesizing medicinal sulfadiazine silver

A technology of silver sulfadiazine and powder of sulfadiazine, which is applied in the field of synthesis of silver sulfadiazine for medicine, can solve problems such as inability to recycle, and achieve the effect of avoiding waste and environmental pollution

Active Publication Date: 2009-12-30
HUNAN ER KANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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After the reaction, the excess cannot be recovered a

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  • Method for synthesizing medicinal sulfadiazine silver

Examples

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Embodiment 1

[0023] Step 1: Preparation of Silver Nitrate Solution

[0024] In the dissolution tank, dissolve 16.4kg (96 moles) of silver nitrate in 135kg of purified water, open the steam valve, heat the silver nitrate solution to 80°C for 30 minutes, and control the steam pressure within 0.2Mpa to replace the silver nitrate solution Close steam valve after dissolving completely, filter, then the silver nitrate filtrate after filtering is squeezed into the head tank I of synthesis tank for subsequent use.

[0025] Step 2: Preparation of Sulfadiazine Sodium Solution

[0026] Add 200kg of purified water to 3.85kg (96 moles) of sodium hydroxide in a dissolving tank to fully dissolve it into a sodium hydroxide solution; add 24.0kg (96 moles) of sulfadiazine powder to the above sodium hydroxide solution, and add Sodium trifluoromethanesulfonate, its consumption is based on the consumption of sulfadiazine powder is 0.1% mol, fully stirs, is heated to 80 ℃, heating time is 30min, until sulfadia...

Embodiment 2

[0035] Prepare silver sulfadiazine in the same manner as in Example 1, except that the amount of sodium trifluoromethanesulfonate used in the step of producing sodium sulfadiazine is 0.3% mol of the amount of sulfadiazine powder, and the reaction temperature in the synthesis step is 55°C.

Embodiment 3

[0037] Prepare silver sulfadiazine in the same manner as in Example 1, except that the amount of sodium trifluoromethanesulfonate used in the step of producing sodium sulfadiazine is 0.5% mol of the amount of sulfadiazine powder, and the reaction temperature in the synthesis step is 49°C.

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Abstract

The invention provides a method for synthesizing medicinal sulfadiazine silver. The method comprises the steps of allowing silver nitrate solution and sulfadiazine sodium solution which are fed and stirred simultaneously to react in a reaction tank, standing, draining, centrifugally drying and obtaining a sulfadiazine silver product, wherein the synthesis reaction temperature of silver nitrate and sulfadiazine sodium is 45 to 55 DEG C, and trifluoromethanesulfonic acid (salt) catalysts are used in the process of utilizing sulfadiazine powder and sodium hydroxide to prepare the sulfadiazine sodium.

Description

technical field [0001] The invention relates to a method for synthesizing medicinal silver sulfadiazine. Background technique [0002] Silver sulfadiazine is white or off-white crystalline powder, which is easy to deteriorate when exposed to light or heat. This product is insoluble in water, ethanol, chloroform or ether. Silver sulfadiazine is included in the second volume of the 2005 edition of the "Chinese Pharmacopoeia", and its category is a sulfonamide antibacterial drug. At present, the purity of the pharmaceutical product of silver sulfadiazine on the market is about 98%. For that purity, there is room to go up. In addition, the production method of silver sulfadiazine is that sulfadiazine powder reacts with sodium hydroxide in a ratio of 1:1 to generate sodium sulfadiazine, and then sodium sulfadiazine reacts with silver nitrate in a ratio of 1:1 to generate silver sulfadiazine. In actual production, in order to improve the utilization rate of relatively expensiv...

Claims

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Application Information

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IPC IPC(8): C07D239/69B01J31/02A61P31/00
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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