Preparation method of poly-amino acid-based triblock copolymer gel

Abstract

The invention relates to a preparation method of poly-amino acid-based triblock copolymer gel, belonging to the technical field of chemical engineering and comprising the following steps: preparing amino-terminated polyethylene glycol macromolecules through alkynyl-terminated polyamide-amine by a click chemistry method; inducing the ring opening polymerization of Gamma-benzyl-L-glutamic acid-N-carboxylic acid anhydride through the amino-terminated polyethylene glycol macromolecules obtained in the first step and preparing a poly (L-benzyl-glutamate)-polyethylene glycol-poly (L-benzyl-glutamate) triblock copolymer; and dissolving the poly (L-benzyl-glutamate)-polyethylene glycol-poly (L-benzyl-glutamate) triblock copolymer obtained in the second step into toluene, heating, stirring, cooling and standing to obtain the gel. The invention forms the symmetrical sector-linear-sector poly-amino acid-based triblock copolymer gel with different topological structures, thereby conveniently adjusting physical and chemical properties of the poly-amino acid-based gel through the topological structures of the macromolecules and the length of the support arms of the copolymer.

Description

Preparation method of polyamino acid-based triblock copolymer gel Technical field The invention relates to a preparation method in the technical field of chemical engineering, in particular to a preparation method of a polyamino acid-based triblock copolymer gel. Background technique Polyamino acids or polypeptides usually have a secondary structure similar to natural proteins (including α-helix, β-sheet, etc.), and under certain conditions (such as temperature, pH, ionic strength, etc.) the conformation of the molecular chain will undergo mutual transformation . Natural branched biomacromolecules and synthetic polyamino acid biomimetic materials are increasingly applied to nanomaterials and biomedical materials due to their biocompatibility, biodegradability, self-assembly properties, and adjustable mechanical properties . At the same time, based on the self-assembly properties of various star-shaped, dendritic, fan-shaped and hyperbranched polymers and the three-dimensiona...

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Problems solved by technology

Its shortcoming is: (1) literature has only studied the gelation phenomenon based on rod-shaped-coil class two-block polyamino acid in toluene, has not studied rod-shaped-coil-rod-shaped three-block polyamino acid-based copolymer Gel phenomenon and mechanism; (2) The literature does not propose a method for preparing branched polyamino acid-based block copolymer organogels with different topological structures, so that it is impossible to adjust the physical and chemical properties of polypeptide organogels through macromolecular topological structures (3) The literature only studies the gelation of polyamino acid diblock copolymers with α-helical secondary structure, and does not study the effect of polyamino acid secondary structure and its concentration on organogels

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