Method for preparing nosiheptide powder

A technology of nosiheptide and fermentation broth, applied in the field of preparation of nosiheptide, can solve the problems of high extraction yield, large pollution and high production cost, and achieve the effects of high yield, no environmental pollution and low cost

Active Publication Date: 2010-01-13
XINYU PHARM CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the shortcomings of high production cost and high pollution in the existing nosiheptide solvent extraction method, and to provide a preparation process for nosiheptide powder, which has no pollution to the environment and high extraction yield

Method used

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Embodiment Construction

[0016] A preparation method for producing nosiheptide powder, comprising the following steps:

[0017] (1), 10 tons of fermented liquid containing nosiheptide obtained through fermentation, the feed liquid temperature is 30 ℃, the fermented liquid enters the metal tubular membrane separator, carries out metal membrane filtration, removes 30% moisture content in the fermented liquid, obtains 7 tons of concentrate.

[0018] Due to the high viscosity of the Nosiheptide fermentation liquid, the method of vacuum high-efficiency evaporation concentration can also be adopted to concentrate the Nosiheptide fermentation liquid to remove 30% of the water.

[0019] (2), the processing rate of the metal tubular membrane separator in step (1) is 0.5 tons / hour; the pressure of entering and exiting the membrane / MPa: 4.0 / 3.0, the pressure difference of entering and exiting the membrane / MPa: 1.0; the temperature of the feed liquid: 30°C, After the treatment, 7 tons of concentrated fermented l...

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Abstract

The invention discloses a method for preparing nosiheptide powder, which comprises the following steps: a. carrying out metallic membrane filtration on fermentation liquid containing nosiheptide obtained in fermentation by using a metal pipe type membrane separator and carrying out concentration treatment to remove 20-35 percent of water in the fermentation liquid to obtain concentrated liquid; b. carrying out spray drying treatment on the obtained concentrated liquid to obtain powder containing nosiheptide; adding auxiliary materials into the nosiheptide powder and diluting the nisiheptide powder level by level to prepare nosiheptide preparations with different forms. The invention has the advantages that nosiheptide can be completely extracted from the fermented liquid of nosiheptide, and the method has high yield, low cost and no environmental pollution.

Description

Technical field: [0001] The invention relates to a preparation method of nosiheptide, in particular to a method for extracting nosiheptide in a fermentation broth. Background technique: [0002] The existing production techniques of nosiheptide and nosiheptide premix all adopt solvent extraction, such as Chinese patent application number 200810062612.8, titled: a method for extracting nosiheptide crude product, which discloses the use of ethanol to ferment Extract nosiheptide from the liquid, concentrate and crystallize the extract to produce nosiheptide powder, and use the nosiheptide powder to produce nosiheptide preparations of different specifications. This process not only has high production cost, but also causes pollution to the environment. Invention content: [0003] The purpose of the present invention is to solve the shortcomings of high production cost and high pollution in the existing nosiheptide solvent extraction method, and to provide a preparation proces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/56C07K1/34
Inventor 李为全刘瑞华朱立元秦艳飞
Owner XINYU PHARM CO LTD
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