Distribution method and distribution device of mobile phases of chromatographic columns

A distribution method and a technology of a distribution device, which are applied in the field of mobile phase distribution in a chromatographic column, can solve the problems of reduced distribution uniformity, uneven initial fluid distribution, and influence on separation effect, so as to achieve easy clogging, easy cleaning and repeated use, The effect of simple structural design

Active Publication Date: 2010-01-27
BEIJING CHUANGXIN TONGHENG SCI & TECH
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Problems solved by technology

But for the larger chromatographic column of diameter, especially the diameter of the chromatographic column of existing industrial preparation chromatogram increases gradually, the distribution uniformity of the fine distribution channel after e

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  • Distribution method and distribution device of mobile phases of chromatographic columns
  • Distribution method and distribution device of mobile phases of chromatographic columns

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[0026] The mobile phase distribution method of the chromatographic column is used for the mobile phase distribution on the upper surface of the stationary phase in the preparation chromatographic column. It uses a circular distributor that matches the cross section of the preparation chromatographic column. The outer tree-shaped divergence is provided with a fluid phase distribution path, and the end of each fluid phase distribution path is provided with a distribution hole. The length of the same specification fluid phase distribution path from the center of the distributor to each distribution hole is equal; Distribute evenly from the center of the distributor to the distribution holes along each fluid phase distribution path, and then evenly distribute to the stationary phase of the chromatographic column. The liquid phase distribution path includes a plurality of first distribution paths diverging from the center to the outside. The end of the first distribution path is conn...

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Abstract

The invention discloses a distribution method and a distribution device of mobile phases of chromatographic columns. The distribution method comprises the steps: adopting a circular distributor matched with a cross section for preparing a chromatographic column; divergently arranging distribution liquid paths of liquid phases outwards in a tree shape along the center on the distributor; installing a distribution hole on the end of each distribution liquid path of liquid phases, wherein the lengths from the center of the distributor to the same-specification distribution liquid paths of liquid phases of all the distribution holes are equal; evenly distributing the liquid phases from the center of the distributor along each distribution liquid path of liquid phases to each distribution hole; and then evenly distributing the liquid phases to fixed phases of chromatographic columns. The distribution method can effectively eliminate the defect that the residence times of the mobile phases on a distribution system have serious differences along with the increase of the diameters of the chromatographic columns, can realize the even initial distribution of the mobile phases entering the chromatographic columns and can not be influenced by the high-pressure transport of the mobile phases. The distribution device has the advantages of simple structural design, difficult blockage, easy washing and repeated use.

Description

technical field [0001] The invention belongs to the distributing technology of mobile phase in a chromatographic column for industrial preparation of chromatography, and in particular relates to a mobile phase distributing method and a distributing device especially suitable for a large-diameter chromatographic column. Background technique [0002] The main purpose of industrial preparative chromatography is to obtain pure substances from mixtures. In order to speed up the separation time and improve the separation efficiency, the amount of sample input to the preparative chromatographic device is large, resulting in a corresponding increase in the separation load of the preparative chromatographic column, and it is necessary to increase the column packing and increase the diameter and length of the preparative chromatographic column. , using a relatively large amount of mobile phase. After the liquid to be treated is injected into the chromatographic column, it moves in th...

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Application Information

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IPC IPC(8): B01D15/18
Inventor 崔万臣沈志刚
Owner BEIJING CHUANGXIN TONGHENG SCI & TECH
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